Modeling the Prevalence of Age-Related Cataract: Waterloo Eye Study

Machan, Carolyn M.; Hrynchak, Patricia K.; Irving, Elizabeth L.

doi:10.1097/opx.0b013e31823ee062

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…A Waterloo Eye Study by reviewing of 6397 clinic files found that diagnosis of T2D resulted in an earlier development of all three cataract subtypes [ 8 ]. Similarly in the present study, we found that the risks of CC and PSC were elevated for patients with the T2D ( P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…The cataract incidence was estimated 3.31 per 1000 person-years of type 2 diabetic patients during 3.6 years’ follow-up [ 4 ]. However, studies [ 5 - 8 ] found that not all types of cataracts [ 9 ], nuclear sclerosis (NS), cortical cataract (CC) or posterior subcapsular (PSC), are more prone to occurring in type 2 diabetes (T2D) patients. Evidence for their association has not been systematically assessed.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of the risk of cataract in type 2 diabetes

2014

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BackgroundThis meta-analysis aimed to investigate the association between type 2 diabetes (T2D) and the risk of cataract.MethodsDatabases of Pubmed, Embase, and SpringerLink were retrieved for observational studies published before November 2013. The odds ratio (OR) and 95% confidence interval (CI) were used for estimating the association. All statistical analyses were performed by Stata 10.0 software.ResultsA total of 8 studies involving 20837 subjects were included in the meta-analysis. The risk of any cataract (AC) in T2D patients was higher than that in non-diabetic subjects (OR = 1.97, 95% CI: 1.45-2.67, P < 0.001). The risks of cortical cataract posterior (CC) (OR = 1.68, 95% CI: 1.47-1.91, P < 0.001) and posterior subcapsular (PSC) (OR = 1.55, 95% CI: 1.27-1.90, P < 0.001) were significantly elevated in T2D patients, while no significant association was found in nuclear sclerosis (NS) (OR = 1.36, 95% CI: 0.97-1.90, P = 0.070).ConclusionT2D patients had a higher risk of cataracts, excepting NS. Special attention should be paid on the ophthalmic extermination, especially for cataract in T2D patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the risk of cataract in type 2 diabetes

2014

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“…13,14 Previous studies focused on prevalence differences of three specific types of lens opacity: nuclear sclerosis, C cataract, and P cataract. Owing to variation of subject race and age, nuclear sclerosis is most commonly noted in Canadian, Chinese, and American whites, [15][16][17] while African, Japanese, and Singaporean present higher prevalence of C cataract than nuclear sclerosis. 16 However, there is scant information about certain factors among different types of lens opacity.…”

Section: Discussionmentioning

confidence: 99%

Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts

Chien

Chen

Liu

et al. 2013

Eye

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Purpose MicroRNA 34a (miR-34a) is involved in regulating tissue senescence. However, the role of miR-34a in age-related cataracts is unclear. In this study, we evaluated the correlations among the severity of lens opacity, patient age, and miR-34a expression level in the lens epithelium of age-related cataracts for clarifying the role of miR-34a in the lens senescence. Methods This study was carried as a case control study in the Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan. We recorded age of each patient at the time of their cataract surgery and information regarding lens opacity according to a modified version of the Lens Opacities Classification System III. Correlations among age, lens opacity, and miR-34a expression levels were evaluated. Results This study evaluated 110 patients with a mean age of 73.19 years (SD±10.2). Older patients had higher nuclear cataract (NC), cortical (C), and posterior subcapsular cataract (P) scores (one-way analysis of variance (ANOVA), Po0.05). miR-34a expression levels were significantly different between each age group (ANOVA post hoc Bonferroni's test, Po0.001), and there were moderate correlations between high NC, C, and P cataract scores and high miR-34a levels (Pearson correlation coefficient; R ¼ 0.606, 0.575, and 0.515, respectively). Conclusions The current study demonstrated positive correlations between high miR-34a levels and high lens opacity severity in NC, C, or P cataracts. These results suggest that miR34a expression has a role in lens senescence.

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“…It is rare for patients to seek treatment for cataract with a single cataract type, so it may not be possible to differentiate these effects in a patient population. 26,27 Additionally, the Lens Opacities Classification System III has remained a mainstay in both clinical practice and research since the early 1990s; however, this test does not take into account specific lens features of cataract, such as water clefts, vacuoles, focal dots, and retro dots, which may affect color vision measurements in different ways. 28,29 The change in visual acuity will not be a factor in explaining the results because the low-vision CCT is designed specifically for use in low vision and performance is independent of visual acuity.…”

Section: Discussionmentioning

confidence: 99%