Modeling ultrasound-induced nucleation during cooling crystallization

Kordylla, Anna; Krawczyk, T.W.; Tumakaka, Feelly; Schembecker, Gerhard

doi:10.1016/j.ces.2008.12.030

Cited by 67 publications

(46 citation statements)

References 20 publications

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“…In addition to these hypotheses which focus on primary nucleation, secondary nucleation was also observed in the literature upon sonication [44]. The fragmentation of crystals by sonication leads to the production of new nucleation sites which create secondary nucleation [44,45]. It therefore remains possible that some nuclei, which are not yet grown to a detectable size, enter the flow cell where they are fragmented by the shear forces or shockwaves induced by the ultrasonic cavitation.…”

Section: Nucleation In Batch Versus Flowmentioning

confidence: 98%

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

et al. 2017

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Controlling particle size is essential for crystal quality in the chemical and pharmaceutical industry. Several articles illustrate the potential of ultrasound to tune this particle size during the crystallization process. This paper investigates how ultrasound can control the particle size distribution (PSD) of acetaminophen crystals by continuous seed generation in a tubular crystallizer followed by batch growth. It is demonstrated that the supersaturation ratio at which ultrasound starts seed generation has a substantial effect on the final PSD while the applied power is insignificant in the studied conditions. The higher the supersaturation ratio, the smaller the final crystals become up to a supersaturation ratio of 1.56. Furthermore, it was shown that ultrasound can also impact the final PSD when applied during the growth phase. Frequencies of 850 kHz or below reduce the final particle size; the lower the applied frequency, the smaller the crystals become. In conclusion, one could state that ultrasound is able to control the particle size during seed generation and subsequent growth until the final particle size.

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Section: Nucleation In Batch Versus Flowmentioning

confidence: 98%

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

et al. 2017

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“…Both an increased and a retarded crystal growth rate were reported [2,[4][5][6]10,14,15,19]. The same holds for the increase [9] and decrease [3,4,6,8,9,12,[16][17][18][19]21,22] of induction periods. A few papers mention a decrease of the metastable zone width [8,10,13,14,18] as well as an enhanced solubility of a sparingly soluble salt [20].…”

Section: Introductionmentioning

confidence: 60%

Seeded calcite sonocrystallization

Boels¹,

Wagterveld²,

Mayer³

et al. 2010

Journal of Crystal Growth

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“…As suggested by Kordylla et al [20] and Yasui et al [21], the occurrence of gas/liquid interface (at the bubble wall) in a supersaturated sonicated solution may induce a kind of heterogeneous nucleation, by reducing interfacial solid-liquid tension and thus reducing the nucleation energy barrier (DG c ) according to the classical nucleation theory (CNT). Kordylla et al [20] has in fact identified the contact angle minimizing a least-square error between experimental and theoretical values.…”

Section: Bibliographical Reviewmentioning

confidence: 97%

“…Kordylla et al [20] has in fact identified the contact angle minimizing a least-square error between experimental and theoretical values. This is however rather a 'curve fitting' approach than a real physical model of sono-nucleation.…”

Section: Bibliographical Reviewmentioning

confidence: 98%

Theoretical model of ice nucleation induced by inertial acoustic cavitation. Part 2: Number of ice nuclei generated by a single bubble

Cogné

Labouret

Peczalski

et al. 2016

Ultrasonics Sonochemistry

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In the preceding paper (part 1), the pressure and temperature fields close to a bubble undergoing inertial acoustic cavitation were presented. It was shown that extremely high liquid water pressures but quite moderate temperatures were attained near the bubble wall just after the collapse providing the necessary conditions for ice nucleation. In this paper (part 2), the nucleation rate and the nuclei number generated by a single collapsing bubble were determined. The calculations were performed for different driving acoustic pressures, liquid ambient temperatures and bubble initial radius. An optimal acoustic pressure range and a nucleation temperature threshold as function of bubble radius were determined. The capability of moderate power ultrasound to trigger ice nucleation at low undercooling level and for a wide distribution of bubble sizes has thus been assessed on the theoretical ground.

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Modeling ultrasound-induced nucleation during cooling crystallization

Cited by 67 publications

References 20 publications

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

Ultrasound Assisted Particle Size Control by Continuous Seed Generation and Batch Growth

Seeded calcite sonocrystallization

Theoretical model of ice nucleation induced by inertial acoustic cavitation. Part 2: Number of ice nuclei generated by a single bubble

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