Modelling and analysis of local field potentials for studying the function of cortical circuits

Einevoll, Gaute T.; Kayser, Christoph; Logothetis, Nikos K.; Panzeri, Stefano

doi:10.1038/nrn3599

Cited by 748 publications

(918 citation statements)

References 159 publications

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“…Neuronal modeling is a very active area of research, with applications ranging from the characterization of neurobiological and cognitive processes, [Bojak and Liley, 2005; Jirsa, 2004a, 2004b; Phillips and Robinson, 2009; Rolls and Treves, 2011] to constructing artificial brains in silico and building brain‐machine interface and neuroprosthetic devices, for example, [Einevoll et al, 2013; Whalen et al, 2013]. …”

Section: Discussionmentioning

confidence: 99%

Intersubject variability and induced gamma in the visual cortex: DCM with empirical Bayes and neural fields

Pinotsis

Perry

Singh

et al. 2016

Human Brain Mapping

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This article describes the first application of a generic (empirical) Bayesian analysis of between‐subject effects in the dynamic causal modeling (DCM) of electrophysiological (MEG) data. It shows that (i) non‐invasive (MEG) data can be used to characterize subject‐specific differences in cortical microcircuitry and (ii) presents a validation of DCM with neural fields that exploits intersubject variability in gamma oscillations. We find that intersubject variability in visually induced gamma responses reflects changes in the excitation‐inhibition balance in a canonical cortical circuit. Crucially, this variability can be explained by subject‐specific differences in intrinsic connections to and from inhibitory interneurons that form a pyramidal‐interneuron gamma network. Our approach uses Bayesian model reduction to evaluate the evidence for (large sets of) nested models—and optimize the corresponding connectivity estimates at the within and between‐subject level. We also consider Bayesian cross‐validation to obtain predictive estimates for gamma‐response phenotypes, using a leave‐one‐out procedure. Hum Brain Mapp 37:4597–4614, 2016. © The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Intersubject variability and induced gamma in the visual cortex: DCM with empirical Bayes and neural fields

Pinotsis

Perry

Singh

et al. 2016

Human Brain Mapping

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“…LFPs represent the summation of local neuron potentials and provide a read-out of oscillations emerging from the synchronization of neurons (Einevoll et al, 2013;FernandezRuiz and Herreras, 2013). This network activity is thought to be fundamental to cognitive processes.…”

Section: Social Stress and Lc Network Activitymentioning

confidence: 99%

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Zitnik

Curtis

Wood

et al. 2015

Neuropsychopharmacol

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Early life stress is associated with the development of psychiatric disorders. Because the locus coeruleus-norepinephrine (LC-NE) system is a major stress-response system that is implicated in psychopathology, developmental differences in the response of this system to stress may contribute to increased vulnerability. Here LC single unit and network activity were compared between adult and adolescent rats during resident-intruder stress. In some rats, LC and medial prefrontal cortex (mPFC) coherence was quantified. The initial stress tonically activated LC neurons and induced theta oscillations, while simultaneously decreasing LC auditory-evoked responses in both age groups. Stress increased LC-mPFC coherence within the theta range. With repeated exposures, adolescent LC neuronal and network activity remained elevated even in the absence of the stressor and were unresponsive to stressor presentation. In contrast, LC neurons of adult rats exposed to repeated social stress were relatively inhibited in the absence of the stressor and mounted robust responses upon stressor presentation. LC sensory-evoked responses were selectively blunted in adolescent rats exposed to repeated social stress. Finally, repeated stress decreased LC-mPFC coherence in the high frequency range (beta and gamma) while maintaining strong coherence in the theta range, selectively in adolescents. Together, these results suggest that adaptive mechanisms that promote stress recovery and maintain basal activity of the brain norepinephrine system in the absence of stress are not fully developed or are vulnerable stress-induced impairments in adolescence. The resulting sustained activation of the LC-NE system after repeated social stress may adversely impact cognition and future social behavior of adolescents.

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“…1F). With an openfield dipole oriented with the sink in the stratum radiatum (SR) and a source around the perisomatic region (4,6,7), the thetafrequency LFP recorded across different sites exhibited a progressive phase shift across recording sites adding to ∼180° (Fig. 1F).…”

Section: Significancementioning

confidence: 99%

“…In recent experimental and modeling studies, there has been a lot of debate on the source and spatial extent of LFPs (1)(2)(3)(4)(5)(6)(7)(8)(9). However, most of these studies have used neurons with passive dendrites in their models and/or have largely focused on the contribution of spike-generating conductances to LFPs (7,8,10,11).…”

mentioning

confidence: 99%

HCN channels enhance spike phase coherence and regulate the phase of spikes and LFPs in the theta-frequency range

Sinha

Narayanan

2015

Proc. Natl. Acad. Sci. U.S.A.

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What are the implications for the existence of subthreshold ion channels, their localization profiles, and plasticity on local field potentials (LFPs)? Here, we assessed the role of hyperpolarizationactivated cyclic-nucleotide-gated (HCN) channels in altering hippocampal theta-frequency LFPs and the associated spike phase. We presented spatiotemporally randomized, balanced theta-modulated excitatory and inhibitory inputs to somatically aligned, morphologically realistic pyramidal neuron models spread across a cylindrical neuropil. We computed LFPs from seven electrode sites and found that the insertion of an experimentally constrained HCN-conductance gradient into these neurons introduced a location-dependent lead in the LFP phase without significantly altering its amplitude. Further, neurons fired action potentials at a specific theta phase of the LFP, and the insertion of HCN channels introduced large lags in this spike phase and a striking enhancement in neuronal spike-phase coherence. Importantly, graded changes in either HCN conductance or its half-maximal activation voltage resulted in graded changes in LFP and spike phases. Our conclusions on the impact of HCN channels on LFPs and spike phase were invariant to changes in neuropil size, to morphological heterogeneity, to excitatory or inhibitory synaptic scaling, and to shifts in the onset phase of inhibitory inputs. Finally, we selectively abolished the inductive lead in the impedance phase introduced by HCN channels without altering neuronal excitability and found that this inductive phase lead contributed significantly to changes in LFP and spike phase. Our results uncover specific roles for HCN channels and their plasticity in phase-coding schemas and in the formation and dynamic reconfiguration of neuronal cell assemblies.L ocal field potentials (LFPs) have been largely believed to be a reflection of the synaptic drive that impinges on a neuron. In recent experimental and modeling studies, there has been a lot of debate on the source and spatial extent of LFPs (1-9). However, most of these studies have used neurons with passive dendrites in their models and/or have largely focused on the contribution of spike-generating conductances to LFPs (7,8,10,11). Despite the widely acknowledged regulatory roles of subthreshold-activated ion channels and their somatodendritic gradients in the physiology and pathophysiology of synapses and neurons (12-17), the implications for their existence on LFPs and neuronal spike phase have surprisingly remained unexplored. This lacuna in LFP analysis is especially striking because local and widespread plasticity of these channels has been observed across several physiological and pathological conditions, translating to putative roles for these channels in neural coding, homeostasis, disease etiology and remedies, learning, and memory (16,(18)(19)(20)(21)(22)(23).In this study, we focus on the role of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that mediate the h current (I h ) in regulating LFPs and ...

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Modelling and analysis of local field potentials for studying the function of cortical circuits

Cited by 748 publications

References 159 publications

Intersubject variability and induced gamma in the visual cortex: DCM with empirical Bayes and neural fields

Intersubject variability and induced gamma in the visual cortex: DCM with empirical Bayes and neural fields

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

HCN channels enhance spike phase coherence and regulate the phase of spikes and LFPs in the theta-frequency range

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