The adoption of lean-burn concepts for internal combustion engines working with a homogenous air/fuel charge is under development as a path to simultaneously improve thermal efficiency, fuel consumption, nitric oxides, and carbon monoxide emissions. This technology may lead to a relevant emission of unburned hydrocarbons (uHC) compared to a stoichiometric engine. The uHC sources are various and the relative importance varies according to fuel characteristics, engine operating point, and some geometrical details of the combustion chamber. This concern becomes even more relevant in the case of engines supplied with natural gas since the methane has a global warming potential much greater than the other major pollutant emissions. In this work, a simulation model describing the main mechanisms for uHC formation is proposed. The model describes uHC production from crevices and flame wall quenching, also considering the post-oxidation. The uHC model is implemented in commercial software (GT-Power) under the form of “user routine”. It is validated with reference to two large bore engines, whose bores are 31 and 46 cm (engines named accordingly W31 and W46). Both engines are fueled with natural gas and operated with lean mixtures (λ > 2), but with different ignition modalities (pre-chamber device or dual fuel mode). The engines under study are preliminarily schematized in the 1D simulation tool. The consistency of 1D engine schematizations is verified against the experimental data of BMEP, air flow rate, and turbocharger rotational speed over a load sweep. Then, the uHC model is validated against the engine-out measurements. The averaged uHC predictions highlight an average error of 7% and 10 % for W31 and W46 engines, respectively. The uHC model reliability is evidenced by the lack of need for a case-dependent adjustment of its tuning constants, also in presence of relevant variations of both engine load and ring pack design.