The twin‐screw configuration problem (TSCP) involves defining the location of a set of predefined screw elements of a corotating twin‐screw extruder configuration to optimize different, often conflicting, objectives. A multiobjective optimization methodology based on Evolutionary Algorithms was developed and applied to solve the TSCP. This methodology is used in starch cationization case studies, involving different screw elements and screw lengths. The results obtained, taking into consideration various conflicting objectives, such as minimizing the specific mechanical energy and maximizing output and reaction efficiency, have physical meaning and thus validate the methodology. POLYM. ENG. SCI., 2011. © 2010 Society of Plastics Engineers