Ensuring the financial and economic security of enterprises in priority sectors of the economy must be a clearly institutionalized process that takes place on an ongoing basis in accordance with the planned phasing of measures and their results on the way to achieving the defined general goal of state regulation. In order to achieve the expected results, an important place is taken by the selection of general scientific and specialized methodological tools, and preference is given to the methods of logical generalization, grouping, structural-functional analysis, and monographic description. A phasing scheme of shifts in the process of implementation by enterprises is proposed, as well as tools and institutional guidelines of the state policy of strengthening the financial security of priority sectors of the national economy of Ukraine. Staged changes in ensuring the financial and economic security of enterprises in priority sectors of the economy of Ukraine are divided into the context of economic (economic and legal regulation, detinization and modernization of capacities, investment and capitalization, development of the market environment, financial support and credit policy) and organizational (institutional support, business qualification – processes, financial and economic integration and cooperation, strategic management, infrastructural support) tools. Institutional guidelines for ensuring the financial and economic security of enterprises in the priority sectors of the Ukrainian economy are formed based directly on the financial (investment, monetary, fiscal, debt, banking, currency, fund, insurance) and economic (normative-legal, institutional-organizational, information-communication) tools , educational and educational, anticyclical, structural, regulatory, competitive) directions. In the perspective of research, it is appropriate to concentrate on improving institutional and legal provisions, identifying tools for the development of organizational and institutional infrastructure, implementing institutional and economic incentives, improving the regulatory and methodological base of financial and economic security of enterprises, priority industries and the state.