Modelling polylactide/water/dioxane systems for TIPS scaffold fabrication

Cocchi, Giovanni; Angelis, Maria Grazia De; Sadowski, Gabriele; Doghieri, Ferruccio

doi:10.1016/j.fluid.2014.04.007

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…Pure-component parameters of PLLA and PDLA were taken from the literature [23] and PGA pure-component parameters were calculated according to a group-contribution method developed by Peters et al [24,25]. All of the model parameters are summarised in Table 1.…”

Section: Plga Modelling Using Pc-saftmentioning

confidence: 99%

Thermodynamic phase behaviour of indomethacin/PLGA formulations

Prudic

Lesniak

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Plga Modelling Using Pc-saftmentioning

confidence: 99%

Thermodynamic phase behaviour of indomethacin/PLGA formulations

Prudic

Lesniak

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…In this modification, the PC-SAFT EOS is able to account for different arrangements of monomers, composition, and molecular weight of copolymers [ 27 , 29 ]. The parameters for homopolymers PLLA and PDLA were obtained from Cocchi et al [ 30 ] and those for PGA from Prudic et al [ 29 ] (see Table 1 ). The monomer compositions in the copolymers studied are provided in Table 2 .…”

Section: Methodsmentioning

confidence: 99%

“…c PLGA and PLA properties are summarized in Table 2 and Table 3 . d Adopted from [ 30 ]. e Adopted from [ 29 ].…”

Section: Figurementioning

confidence: 99%

Effect of Copolymer Properties on the Phase Behavior of Ibuprofen–PLA/PLGA Mixtures

et al. 2023

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Prediction of compatibility of the active pharmaceutical ingredient (API) with the polymeric carrier plays an essential role in designing drug delivery systems and estimating their long-term physical stability. A key element in deducing API–polymer compatibility is knowledge of a complete phase diagram, i.e., the solubility of crystalline API in polymer and mutual miscibility of API and polymer. In this work, the phase behavior of ibuprofen (IBU) with different grades of poly(D,L-lactide-co-glycolide) (PLGA) and polylactide (PLA), varying in composition of PLGA and molecular weight of PLGA and PLA, was investigated experimentally using calorimetry and computationally by the perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state (EOS). The phase diagrams constructed based on a PC-SAFT EOS modeling optimized using the solubility data demonstrated low solubility at typical storage temperature (25 °C) and limited miscibility (i.e., presence of the amorphous–amorphous phase separation region) of IBU with all polymers studied. The ability of PC-SAFT EOS to capture the experimentally observed trends in the phase behavior of IBU–PLA/PLGA systems with respect to copolymer composition and molecular weight was thoroughly investigated and evaluated.

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“…It is well-known, that many polymers undergo phase separation when mixed with solvents − or other polymers. , The complex phase behavior of polymer/solvent systems has been characterized, e.g., for the design of polymer production processes. , Many polymer/solvent mixtures are known to undergo phase separation (e.g., poly(ethylene glycol)/water or poly(lactic acid)/water). Phase separation in polymeric systems has been successfully described by thermodynamic models taking into account the complex polymer architecture and the chain-like structure, using the Flory–Huggins theory, the lattice–cluster theory, or the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) .…”

Section: Introductionmentioning

confidence: 99%

“…Phase separation in polymeric systems has been successfully described by thermodynamic models taking into account the complex polymer architecture and the chain-like structure, using the Flory–Huggins theory, the lattice–cluster theory, or the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) . PC-SAFT is a thermodynamic model applicable for describing phase equilibria (vapor sorption and amorphous phase separation (APS) , ) in polymer/solvent mixtures, , the solubility of APIs in organic solvents and water, , and the phase behavior of ASDs (solubility of APIs in polymers, APS, and the influence of moisture on solubility , and APS , ). In this work, PC-SAFT is used to calculate phase equilibria in API/polymer/solvent mixtures and to gain, for the first time, a thermodynamic understanding of APS.…”

Section: Introductionmentioning

confidence: 99%

Choosing Appropriate Solvents for ASD Preparation

2018

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Amorphous solid dispersions (ASDs) are often used for formulating poorly water-soluble active pharmaceutical ingredients (APIs). In an ASD, the amorphous API is embedded in a suitable matrix excipient in order to stabilize the amorphous state and control the dissolution performance. ASDs can be prepared by commonly dissolving the API and the polymer in a suitable organic solvent which is evaporated afterward (e.g., via spray drying) aiming at a homogeneous API distribution in the polymer matrix. Sometimes, unexpected solvent influences on the heterogeneity of the dry ASD are observed. Thermodynamic predictions using the Perturbed-Chain Statistical Associating Fluid Theory combined with experimental investigations via Raman spectroscopy, differential scanning calorimetry, and microscopy performed in this work revealed the amorphous phase separation (APS) between the solvent and the polymer as causing the ASD heterogeneities. It will be shown that thermodynamic modeling allows for identifying appropriate solvents that will neither show APS with the polymeric excipient nor at any time of the drying process of ASD formulations.

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Modelling polylactide/water/dioxane systems for TIPS scaffold fabrication

Cited by 11 publications

References 25 publications

Thermodynamic phase behaviour of indomethacin/PLGA formulations

Thermodynamic phase behaviour of indomethacin/PLGA formulations

Effect of Copolymer Properties on the Phase Behavior of Ibuprofen–PLA/PLGA Mixtures

Choosing Appropriate Solvents for ASD Preparation

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