Modelling the Effect of a Novel Autodissemination Trap on the Spread of Dengue in Shah Alam and Malaysia

Liang, Y.; Mohiddin, M. N. Ahmad; Bahauddin, R.; Hidayatul, F. O.; Nazni, Wasi Ahmad; Lee, H. L.; Greenhalgh, David

doi:10.1155/2019/1923479

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…A good relationship was obtained from various field trials with the percentage of pupal mortality and proportion of sentinel contamination to positively correlation (r=0.6) between the parameters [14]. Our recent finding through mathematical modeling and simulation found out that a sufficient number of MHS placed in the study area could reduced dengue cases up to 91% [62]. This indicates that the autodissemination station and Mosquito Home AQ used in this study have good potential in attracting wild mosquitoes and subsequently disseminate pyriproxyfen to other containers under natural environments.…”

Section: Discussionmentioning

confidence: 88%

Small-scale field assessment of efficacy of the autodissemination approach against Aedes sp. in an urban area

Ngesom¹,

Othman

Bahauddin³

et al. 2020

Preprint

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This is the first study to evaluate the efficacy of an autodissemination approach, as suggested by WHO. Therefore, the efficacy of an autodissemination approach in small-scale field trials against wild Aedes sp. population was evaluated in an urbanized setting, Malaysia. Lethal ovitraps enhanced with pyriproxyfen were used to control Aedes sp. populations at treatment sites, with the autodissemination activity was assessed using the WHO larval bioassays. Lethal ovitraps enhanced with pyriproxyfen effectively reduced of Aedes sp. population. All autodissemination stations were shown to be visited by Aedes sp. mosquitoes with 100% complete inhibition against eggs and larvae development. In the larvae bioassay, pupae mortality ranged from 14 to 40%. Statistically, a significant reduction of Aedes sp. population in the treatment sites compared to the untreated areas. The study proved for the autodissemination of pyriproxyfen to breeding habitats by wild Aedes sp. This technique is highly potentially for vector control activities. Future evaluation should focus on large-scale field trials.Author SummarySince 2012, Dataran Automobil, Seksyen 15, Shah Alam, was declared as one of the dengue hotspot areas. Major vector control activities were conducted by government, NGOs, social communities, and local authorities, but the number still rising. We conducted a new invention of autodissemination concepts in this area by an entomological study on mosquito populations reduction and dispersal abilities of the technique. We found that the technique has proven to control mosquito populations, but the other factors such as epidemiology link still unclear and need further clarification. Our finding highlighted the effectiveness of autodissemination strategies that can be considered as one of the alternative tools in vector control programme.

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Section: Discussionmentioning

confidence: 88%

Small-scale field assessment of efficacy of the autodissemination approach against Aedes sp. in an urban area

Ngesom¹,

Othman

Bahauddin³

et al. 2020

Preprint

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“…The "pull" component uses a formulation with an attractant ingredient lure against female mosquitoes to breed inside the AHM while the "push" component refers to the contaminated mosquitoes dispersing after ovipositing their eggs. In this method, female mosquitoes are used as a carrier for the transfer of insecticide to other containers, and thus disseminating the insecticide to the larval habitats (Liang et. at., 2019).…”

Section: Aedestech Mosquito Home (Ahm)mentioning

confidence: 99%

A Review: Autodissemination of Pyriproxyfen as Novel Strategy to Control Dengue Outbreaks

Ngesom¹,

Greenhalgh²,

Lasim³

et al. 2020

JST

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The new emergence and re-emergence of arbovirus infections transmitted by Aedes mosquitoes have been spreading across Southeast Asia, Central Africa, United States, tropical Oceania and has become a major of public health concern. These arbovirus diseases were found to have a similar vector, symptoms, and environments. The situation is complex due to no specific vaccine or treatments being available for the diseases. Therefore, vector control is currently the best defense against arbovirus diseases, but with its own challenges such as the difficulty in controlling scattered breeding sites and biological behavior. Herein, we present a literature review of studies on current techniques proposed to combat dengue transmission that can fill a crucial gap in vector control programs, which is the inability of conventional control methods to eliminate and destroy cryptic breeding sites. In particular, we focused on the concept of autodissemination, which is a self-delivery technique by manipulating the behavior of mosquitoes, carrying the insecticide and disseminating it to cryptic breeding sites. This technique has shown promising results in some countries and can be considered as an additional tool in a vector control program. Therefore, we conducted Boolean searches in several electronic databases including Google Scholar, PubMed, SciELO and ScienceDirect to identify relevant published data regarding dengue and autodissemination techniques.

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“…In Malaysia, Aedes aegypti and Aedes albopictus are the primary and secondary mosquito species responsible for dengue transmission [ 3 ]. The incidence of dengue in Malaysia increased from 31.6 reported cases per 100,000 inhabitants in the year 2000 to 159.7 in 2010 [ 4 ] and to 396.4 per 100,000 inhabitants in 2015 [ 5 ]. In 2010, the country spent an estimated US$73.5 million (95% confidence interval CI = US$62.0–US$86.3 million) on the national dengue vector control programme [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Measuring the effectiveness of integrated vector management with targeted outdoor residual spraying and autodissemination devices on the incidence of dengue in urban Malaysia in the iDEM trial (intervention for Dengue Epidemiology in Malaysia): study protocol for a cluster randomized controlled trial

Saadatian‐Elahi

Alexander

Möhlmann

et al. 2021

Trials

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Background In common with many South East Asian countries, Malaysia is endemic for dengue. Dengue control in Malaysia is currently based on reactive vector management within 24 h of a dengue case being reported. Preventive rather than reactive vector control approaches, with combined interventions, are expected to improve the cost-effectiveness of dengue control programs. The principal objective of this cluster randomized controlled trial is to quantify the effectiveness of a preventive integrated vector management (IVM) strategy on the incidence of dengue as compared to routine vector control efforts. Methods The trial is conducted in randomly allocated clusters of low- and medium-cost housing located in the Federal Territory of Kuala Lumpur and Putrajaya. The IVM approach combines: targeted outdoor residual spraying with K-Othrine Polyzone, deployment of mosquito traps as auto-dissemination devices, and community engagement activities. The trial includes 300 clusters randomly allocated in a 1:1 ratio. The clusters receive either the preventive IVM in addition to the routine vector control activities or the routine vector control activities only. Epidemiological data from monthly confirmed dengue cases during the study period will be obtained from the Vector Borne Disease Sector, Malaysian Ministry of Health e-Dengue surveillance system. Entomological surveillance data will be collected in 12 clusters randomly selected from each arm. To measure the effectiveness of the IVM approach on dengue incidence, a negative binomial regression model will be used to compare the incidence between control and intervention clusters. To quantify the effect of the interventions on the main entomological outcome, ovitrap index, a modified ordinary least squares regression model using a robust standard error estimator will be used. Discussion Considering the ongoing expansion of dengue burden in Malaysia, setting up proactive control strategies is critical. Despite some limitations of the trial such as the use of passive surveillance to identify cases, the results will be informative for a better understanding of effectiveness of proactive IVM approach in the control of dengue. Evidence from this trial may help justify investment in preventive IVM approaches as preferred to reactive case management strategies. Trial registration ISRCTN ISRCTN81915073. Retrospectively registered on 17 April 2020.

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Modelling the Effect of a Novel Autodissemination Trap on the Spread of Dengue in Shah Alam and Malaysia

Cited by 9 publications

References 19 publications

Small-scale field assessment of efficacy of the autodissemination approach against Aedes sp. in an urban area

Small-scale field assessment of efficacy of the autodissemination approach against Aedes sp. in an urban area

A Review: Autodissemination of Pyriproxyfen as Novel Strategy to Control Dengue Outbreaks

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