Modelling the fate of micropollutants in integrated urban wastewater systems: Extending the applicability to pharmaceuticals

Compagni, Riccardo Delli; Polesel, Fabio; Borries, Kerstin J. F. von; Zhang, Zhen; Turolla, Andrea; Antonelli, Manuela; Vezzaro, Luca

doi:10.1016/j.watres.2020.116097

Cited by 13 publications

(7 citation statements)

References 72 publications

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“…So far, only Delli Compagni et al ( 2020 ) made an effort to incorporate back-transformation due to deconjugation into a sewer-specific fate model (IUWS_MP model) by specifying a simple, compound-specific first-order process rate. Modelling back-transformation this way again heavily relies on empirical data regarding deconjugation rate constants.…”

Section: In-sewer Fate Processes: Theory and Modellingmentioning

confidence: 99%

“…Given that deconjugation of glucuronide metabolites is reported to proceed within several hours (Brown et al 2020 ; D’Ascenzo et al 2003 ) we assume that under most sewer residence times back-transformation is very likely to be initiated already upon passage through the sewer system and completed during wastewater treatment as observed by D’Ascenzo et al ( 2003 ). However, when assuming full deconjugation of metabolites into their respective parent compound Delli Compagni et al ( 2020 ) observed overestimation of parent compounds in WWTP influent. This suggests, that measured WWTP removal efficiencies might underestimate ‘true’ removal if only parent compounds are measured since conjugated metabolites likely back-transform into parent compounds while parent compounds are being removed.…”

Section: In-sewer Fate Processes: Theory and Modellingmentioning

confidence: 99%

“…For example, Vollertsen et al ( 2015 ) developed a model to predict the production of hydrogen sulfide (sewer gas) and wastewater pH in the sewers of San Francisco; Li et al ( 2019 b ) modelled real-time sewer flow in Australia under different weather conditions; Vezzaro et al ( 2014 ) developed a dynamic sewer model including fate of CECs. This latter model was recently expanded by Delli Compagni et al ( 2020 ) and considers in its latest version also back-transformation due to deconjugation and sequestration of CECs in feces. Other researchers recently reviewed in detail general fate models for various chemicals and their application domains (e.g.…”

Section: Integrated Fate Modelling Of Cecs In Sewersmentioning

confidence: 99%

“…Since underlying mechanisms are not yet deterministically described, both models assume full deconjugation of metabolites into their respective parent compound. However, Delli Compagni et al ( 2020 ) indicated that this assumption might overestimate pharmaceutical loads in WWTP influent. Furthermore, all models assume biotransformation to be the major process in affecting the load of CECs in sewer systems.…”

Section: Integrated Fate Modelling Of Cecs In Sewersmentioning

confidence: 99%

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The role of the sewer system in estimating urban emissions of chemicals of emerging concern

Zillien

Posthuma

Roex

et al. 2022

Rev Environ Sci Biotechnol

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The use of chemicals by society has resulted in calls for more effective control of their emissions. Many of these chemicals are poorly characterized because of lacking data on their use, environmental fate and toxicity, as well as lacking detection techniques. These compounds are sometimes referred to as contaminants of emerging concern (CECs). Urban areas are an important source of CECs, where these are typically first collected in sewer systems and then discharged into the environment after being treated in a wastewater treatment plant. A combination of emission estimation techniques and environmental fate models can support the early identification and management of CEC-related environmental problems. However, scientific insight in the processes driving the fate of CECs in sewer systems is limited and scattered. Biotransformation, sorption and ion-trapping can decrease CEC loads, whereas enzymatic deconjugation of conjugated metabolites can increase CEC loads as metabolites are back-transformed into their parent respective compounds. These fate processes need to be considered when estimating CEC emissions. This literature review collates the fragmented knowledge and data on in-sewer fate of CECs to develop practical guidelines for water managers on how to deal with in-sewer fate of CECs and highlights future research needs. It was assessed to what extent empirical data is in-line with text-book knowledge and integrated sewer modelling approaches. Experimental half-lives (n = 277) of 96 organic CECs were collected from literature. The findings of this literature review can be used to support environmental modelling efforts and to optimize monitoring campaigns, including field studies in the context of wastewater-based epidemiology. Graphical abstract

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Section: In-sewer Fate Processes: Theory and Modellingmentioning

confidence: 99%

Section: In-sewer Fate Processes: Theory and Modellingmentioning

confidence: 99%

Section: Integrated Fate Modelling Of Cecs In Sewersmentioning

confidence: 99%

Section: Integrated Fate Modelling Of Cecs In Sewersmentioning

confidence: 99%

See 2 more Smart Citations

The role of the sewer system in estimating urban emissions of chemicals of emerging concern

Zillien

Posthuma

Roex

et al. 2022

Rev Environ Sci Biotechnol

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“…The contribution of this pathway to total emissions is estimated to be in the range of a mere few percents, except for some developing countries with highly concentrated pharmaceutical industries (Caldwell, 2016). On the more important consumer side, there are two, partially intertwined, pathways incorporating a complex sequence of loss processes occurring from purchasing the chemical to actual emissions into surface waters (Delli Compagni et al, 2020). After purchase, the two consumer pathways get separated.…”

Section: Introductionmentioning

confidence: 99%

From market to environment – consumption-normalised pharmaceutical emissions in the Rhine catchment

Varga

Fenner

Singer

et al. 2023

Preprint

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Direct and indirect threats by organic micropollutants can only be reliably assessed and prevented if the exposure to these chemicals is known, which in turn requires a confident estimate of their emitted amounts into the environment. APIs (Active Pharmaceutical Ingredients) enter surface waters mostly through the sewer system and wastewater treatment plants (WWTPs). However, their effluent fluxes are highly variable and influenced by several different factors that challenge robust emission estimates. Here, we defined a dimensionless, theoretically consumption-independent ‘escape factor’ (kesc) for estimating the amount of APIs (expected to be) present in WWTP effluents. The factor is determined as the proportion of marketed and actually emitted amounts of APIs. A large collection of German and Swiss monitoring datasets were analysed to calculate stochastic kesc values for 31 APIs, reflecting both the magnitude and uncertainty of consumption-normalised emissions. Escape factors provide an easy-to-use tool for the estimation of average API emissions and expected variability from numerous WWTPs given that consumption data are provided, thereby supporting simulation modeling of the fate of APIs in stream networks or exposure assessments.

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Fast and Efficient Sensing of Drugs in Water Using Self‐Assembling D‐Glucamine‐Functionalized Naphthalenediimide and 1,8‐Naphthalimide Fluorophores

Marullo,

Arena,

Lazzara

et al. 2024

Chemistry A European J

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Fast and sensitive quantification of drugs as emerging pollutants in water bodies is a pressing need in contemporary society, to prevent serious environmental concerns that could negatively impact on human health. This explains the surge of interest in this field, and the need to identify highly selective sensing systems. Addressing this issue, in this work we synthesized two D‐glucamine functionalized fluorophores bearing self‐assembling cores, as 1,8‐naphthalimide and naphthalene diimide. We studied their self‐assembly in water solution, and characterized the aggregated formed by determining their stability constant, their morphology and size by scanning electron microscopy, resonance light scattering and dynamic light scattering, as well their solid‐state emission ability. Then, we studied their sensing ability, in water, towards pharmaceutically active compounds such as ciprofloxacin, nalidixic acid, carbamazepine and diclofenac sodium salt, by fluorescence investigation. Data collected show that the self‐assembling ability is significantly affected by the fluorophore structure, which in turn also determines sensing ability. In particular, the naphtalene diimide‐based probe was the most sensitive, with LOD as low as 0.01 mM in the presence of nalidixic acid, which is in line and competitive with more complex sensing systems, recently reported in the literature.

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Modelling the fate of micropollutants in integrated urban wastewater systems: Extending the applicability to pharmaceuticals

Cited by 13 publications

References 72 publications

The role of the sewer system in estimating urban emissions of chemicals of emerging concern

The role of the sewer system in estimating urban emissions of chemicals of emerging concern

From market to environment – consumption-normalised pharmaceutical emissions in the Rhine catchment

Fast and Efficient Sensing of Drugs in Water Using Self‐Assembling D‐Glucamine‐Functionalized Naphthalenediimide and 1,8‐Naphthalimide Fluorophores

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