Models of Abnormal Scarring

Seo, Bommie Florence; Lee, Jun Yong; Jung, Sung-No

doi:10.1155/2013/423147

Cited by 54 publications

(52 citation statements)

References 69 publications

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“…Valuable translation vehicles for human treatment modalities, which includes wound healing, are animal models [20]. In experimental wound healing assays, rodents are the most widely used animals due to their physiology that is closer to humans.…”

Section: Discussionmentioning

confidence: 99%

Cocos nucifera L. endosperm promotes healing of excised wound in BALB/c mice

Samaniego¹,

Cena²,

Agapito³

et al. 2018

mpj

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Mature endosperm of Cocos nucifera L. (family Arecaceae) has been used in folkloric medicine as wound healing agent. However, valuable scientific evidence of its traditional use has not yet been verified. This study evaluates the wound healing activity of C. nucifera endosperm on the excised wound in BALB/c mice. Three concentrations (30%, 60% and 90%) of C. nucifera endosperm were prepared as ointment using petroleum jelly as base. The safety of the formulation was evaluated using dermal irritation test. The prepared concentrations, Solcoseryl® ointment (positive control) and petroleum jelly (negative control) were topically applied daily on the excised wound and observed for wound healing activity for 14 days, with histological evaluations at days 7 and 14. The 90% C. nucifera endosperm ointment showed no clinical signs of dermal irritation during the study duration, confirming the safety for topical usage of all the C. nucifera formulation. All groups demonstrated scab formation and wound contraction at days 7 and 9, respectively. Healing of the wounds, manifested by distinct wound contraction, was observed at day 14, with 60% C. nucifera endosperm exhibiting significant activity compared to the negative control (p=0.009) and untreated (p=0.046) groups. It also displayed the highest activity, with notable similarity in the activity of Solcoseryl®, and revealed the most organized epidermis comparable to normal skin. This study validates the folkloric use of C. nucifera endosperm in facilitating wound healing process, with 60% C. nucifera endosperm exhibiting the most desirable activity.

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Section: Discussionmentioning

confidence: 99%

Cocos nucifera L. endosperm promotes healing of excised wound in BALB/c mice

Samaniego¹,

Cena²,

Agapito³

et al. 2018

mpj

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“…Keloid scars are abnormally proliferative scars that are caused by an aberration in the normal wound healing process [2]. Keloids commonly occur around the ears, usually due to piercings [7].…”

Section: Discussionmentioning

confidence: 99%

“…Keloids, along with hypertrophic scars, are caused by an aberration in the normal wound healing process and inflict great discomfort on the patient [2]. Abnormal scars may cause pain or pruritus, disturb the range of motion, diminish sensation, or cause aesthetic deformities that may lead to significant psychosocial distress.…”

Section: Introductionmentioning

confidence: 99%

V-Y Advancement Flap: Aesthetic Reconstruction for Auriculotemporal Keloid Excision

Seo

Kwon

et al. 2017

Arch Aesthetic Plast Surg

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Keloid scars are commonly found on the ears. Treatment modalities include compression, intralesional steroid injection, and surgical excision with or without radiotherapy, depending on the size and location of the keloid scar. Excision may be a curative solution, but it always requires the immediate reconstruction of the excised defect. Herein, we report the case of a keloid scar located at the helical base of the auriculotemporal sulcus that was treated by excision and a V-Y temporal advancement flap.

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“…64 Yorkshire pigs and red Duroc pigs are used. 73 Wounds on the backs of red Duroc pigs show expression of cytokines, transcription factors, growth factors, and receptors similar to human scars. 73 Yet, the scars tend to diminish and the model can be used up to 5 months.…”

Section: Scarless Regeneration In Animal Modelsmentioning

confidence: 99%

“…73 Wounds on the backs of red Duroc pigs show expression of cytokines, transcription factors, growth factors, and receptors similar to human scars. 73 Yet, the scars tend to diminish and the model can be used up to 5 months. 74 Although pig scars are the closest animal model to human scars, the skin structure in pigs and humans is not identical: (1) pig epidermis has only three layers as opposed to five in humans, (2) pigs have a thick and compact stratum corneum, (3) the distribution of apocrine and eccrine sweat glands are different, (4) the architecture of hair follicles is different.…”

Section: Scarless Regeneration In Animal Modelsmentioning

confidence: 99%

Scarless Tissue Regeneration

Golberg¹

2017

Frontiers in Nanobiomedical Research

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Wounds and wound healing are parts of every organism's life. What is a wound, how does it heal and what can we do to speed the healing, but decrease scarring? All these fundamental questions occupy the minds of people through all known history. Wound healing is an extremely complex phenomenon, which involves both the organism and its environment. Moreover, chemical, biological, mechanical and electrical forces drive this phenomenon. This chapter attempts to combine various aspects of wound healing phenomena with an emphasis on scarless regeneration. The system approach to wound healing is needed to develop new therapies. This chapter starts with the general overview on what is a wound from the system perspective. Then it describes the highlevel events that take place during normal and abnormal wound healing. Next, it gives a historic perceptive on the history of wound healing in humans. Then it describes the fundamentals of scar biology, going to the details of known biochemical and cellular events involved in the process of scar formation. It then deals with the mechanical and electrical events that affect wound healing process. Next, complex events such as inflammation and wound-bacteria interaction are discussed, followed by descriptions of the in vitro and in vivo models of scarless wound healing. This chapter concludes with open questions and future perspectives of scarless wound healing.

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Models of Abnormal Scarring

Cited by 54 publications

References 69 publications

Cocos nucifera L. endosperm promotes healing of excised wound in BALB/c mice

Cocos nucifera L. endosperm promotes healing of excised wound in BALB/c mice

V-Y Advancement Flap: Aesthetic Reconstruction for Auriculotemporal Keloid Excision

Scarless Tissue Regeneration

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