2004
DOI: 10.1159/000077480
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Models of chromosome aberration induction: an example based on radiation track structure

Abstract: A few examples of models of chromosome aberration induction are summarised and discussed on the basis of the three main theories of aberration formation, that is “breakage-and-reunion”, “exchange” and “one-hit”. A model and code developed at the Universities of Milan and Pavia is then presented in detail. The model provides dose-response curves for different aberration types (dicentrics, translocations, rings, complex exchanges and deletions) induced in human lymphocytes by gamma rays, protons and alpha partic… Show more

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Cited by 18 publications
(9 citation statements)
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“…The results obtained in terms of "biological dose" (average number of CLs per cell) can be interpreted on the basis of our model of chromosome aberration induction, e.g., [9,10], which is based on the hypothesis that two CLs in the same cell can give rise to a chromosome aberration if they are induced sufficiently close. According to this model, a yield of 4.8 CL/cell (that is what we found for skin behind 1 g/cm 2 Al) implies that each exposed cell has about a 0.3 probability to be affected by a translocation, which is an important aberration type because it is correlated with cell conversion to malignancy.…”
Section: Applications To Space Radiation Protectionmentioning
confidence: 97%
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“…The results obtained in terms of "biological dose" (average number of CLs per cell) can be interpreted on the basis of our model of chromosome aberration induction, e.g., [9,10], which is based on the hypothesis that two CLs in the same cell can give rise to a chromosome aberration if they are induced sufficiently close. According to this model, a yield of 4.8 CL/cell (that is what we found for skin behind 1 g/cm 2 Al) implies that each exposed cell has about a 0.3 probability to be affected by a translocation, which is an important aberration type because it is correlated with cell conversion to malignancy.…”
Section: Applications To Space Radiation Protectionmentioning
confidence: 97%
“…Event-byevent codes can be successfully applied up to the cellular level, i.e., at the µm scale. Examples of applications of such codes to the simulation of DNA damage, cell death, and chromosome aberrations can be found in [7][8][9][10]. However, the "event-by-event" approach cannot be applied to the case of tissues and organs since it would require unacceptable computing time.…”
Section: Integration Of Data Into "Condensed-history" Codesmentioning
confidence: 99%
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“…The interested reader can consult Refs 18,19) for the GSI work and Ref [20][21][22][23][24][25] for some contributions to this field by French, Italian and Swedish research groups.…”
Section: European Research In Radiobiologymentioning
confidence: 99%
“…The main assumption of our model [15][16][17] consists of considering chromosome aberrations as the "evolution" of clustered DNA breaks or "Complex Lesions" (CLs), which have been operationally defined as "at least two breaks in each of the two DNA strands within 30 base-pairs" [6]. Regardless of the definition, which is necessary to get quantitative simulation results, the key point is that these lesions are clustered, and thus severe and difficult to be processed by the cell repair machinery.…”
Section: Induction Of Chromosome Aberrations By Ionizing Radiationmentioning
confidence: 99%