“…Variants of the model have captured the changes in viral load when this balance is perturbed using antiretroviral therapy (ART) and yielded estimates of the half‐lives of virions and infected cells in vivo (Ho et al, ; Nowak & May, ; Perelson, ; Perelson, Neumann, Markowitz, Leonard, & Ho, ; Wei et al, ). The models have also been extended to other viruses (Best et al, ; Dixit, Layden‐Almer, Layden, & Perelson, ; Neumann et al, ; Nowak et al, ; Padmanabhan & Dixit, ; Padmanabhan, Garaigorta, & Dixit, ). It has been of interest to estimate the contribution of effector CD8 + T cells in the observed loss of infected cells (Gadhamsetty, Beltman, & de Boer, ).…”