Moderate aerobic exercise training ameliorates impairment of mitochondrial function and dynamics in skeletal muscle of high‐fat diet‐induced obese mice

Heo, Jun‐Won; No, Mi‐Hyun; Cho, Jinkyung; Choi, Youngju; Cho, Eun‐Jeong; Park, Dong‐Ho; Kim, Tae‑Woon; Kim, Chang‐Ju; Seo, Dae Yun; Han, Jin; Jang, Young C.; Jung, Su‐Jeen; Kang, Ju‐Hee; Kwak, Hyo‐Bum

doi:10.1096/fj.202002394r

Cited by 22 publications

(20 citation statements)

References 43 publications

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“…In addition, the HFHC+EX increased fusion proteins (Mfn1) and reduced fission protein (Fis1) than the HFHC. Parallel results were observed by other studies, which investigated the expression of Mfn1 and Mfn2 in skeletal muscle tissues in animal [ 63 ] and human models [ 64 ]. The underlying mechanism of the effects of exercise training on mitochondria in the lung cells is complicated.…”

Section: Discussionsupporting

confidence: 87%

Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD

Cho

Johnson

Watt

et al. 2022

BMC Med

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Background Non-alcoholic fatty liver disease (NAFLD) can lead to pulmonary dysfunction that is associated with pulmonary inflammation. Moreover, little is known regarding the therapeutic role of exercise training on pulmonary pathophysiology in NAFLD. The present study aimed to investigate the effect of exercise training on high-fat high-carbohydrate (HFHC)-induced pulmonary dysfunction in C57BL/6 mice. Methods Male C57BL/6 mice (N = 40) were fed a standard Chow (n = 20) or an HFHC (n = 20) diet for 15 weeks. After 8 weeks of dietary treatment, they were further assigned to 4 subgroups for the remaining 7 weeks: Chow (n = 10), Chow plus exercise (Chow+EX, n = 10), HFHC (n = 10), or HFHC plus exercise (HFHC+EX, n = 10). Both Chow+EX and HFHC+EX mice were subjected to treadmill running. Results Chronic exposure to the HFHC diet resulted in obesity with hepatic steatosis, impaired glucose tolerance, and elevated liver enzymes. The HFHC significantly increased fibrotic area (p < 0.001), increased the mRNA expression of TNF-α (4.1-fold, p < 0.001), IL-1β (5.0-fold, p < 0.001), col1a1 (8.1-fold, p < 0.001), and Timp1 (6.0-fold, p < 0.001) in the lung tissue. In addition, the HFHC significantly altered mitochondrial function (p < 0.05) along with decreased Mfn1 protein levels (1.8-fold, p < 0.01) and increased Fis1 protein levels (1.9-fold, p < 0.001). However, aerobic exercise training significantly attenuated these pathophysiologies in the lungs in terms of ameliorating inflammatory and fibrogenic effects by enhancing mitochondrial function in lung tissue (p < 0.001). Conclusions The current findings suggest that exercise training has a beneficial effect against pulmonary abnormalities in HFHC-induced NAFLD through improved mitochondrial function.

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Section: Discussionsupporting

confidence: 87%

Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD

Cho

Johnson

Watt

et al. 2022

BMC Med

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“…That study suggested that the HFD and low-intensity endurance training modulated mitochondrial dynamics, contributing to insulin sensitivity, whereas they failed to generate an additive effect on mitochondrial biogenesis. In line with the above, no change in the MFN1 protein levels were detected in male C57BL/6 mice (4-week-old) fed a HFD ( 74 ). However, MFN2 and OPA1 protein levels were assessed at a lower level in the HFD-fed mice ( 74 ).…”

Section: Dietssupporting

confidence: 82%

“…In line with the above, no change in the MFN1 protein levels were detected in male C57BL/6 mice (4-week-old) fed a HFD ( 74 ). However, MFN2 and OPA1 protein levels were assessed at a lower level in the HFD-fed mice ( 74 ). These findings suggest that moderate aerobic training can only mitigate insulin resistance and mitochondrial dysfunction that are induced by obesity.…”

Section: Dietssupporting

confidence: 82%

The impact of diet upon mitochondrial physiology (Review)

et al. 2022

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Mitochondria are considered the 'powerhouses' of cells, generating the essential energy in the form of adenosine triphosphate that they need for their energy demands. Nevertheless, their function is easily adaptable as regards the energy demands and the availability of chemical substrates. This allows cells to buffer sudden changes and reassure cellular metabolism, growth or survival. currently, humans have different dietary habits, which provide several stimuli to the cell. According to the energy substrate availability due to the diet quality and diet temporality, mitochondrial physiology is greatly affected. The present review article aimed to collect all the available information that has been published to date concerning the impact of five different popular diets (high-fat diet, ketogenic diet, fasting, caloric restriction diet and the Mediterranean diet) on specific mitochondrial physiological aspects, such as function, biogenesis, mitophagy and mitochondrial fission/fusion. Contents 1. Mitochondrial physiology 2. diets 3. clinical impact 4. conclusions

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“…The etiology of lung cancer is still not completely clear at present, and a large amount of data indicate that its pathogenic factors mainly include smoking, occupational exposure, air pollution, ionizing radiation, dietary habit, genetics, history of lung diseases, and so on. For the patients with medium and advanced lung cancer, the radiochemotherapy is an indispensable treatment, but it tends to cause nausea, vomiting, pain, fatigue, reduced physical activity endurance and other adverse symptoms, and affect the patients' respiratory system, resulting in the deterioration of their quality of life [ 2 , 3 ]. Therefore, effective nursing and rehabilitation training, along with the treatment, are needed to be given to the patients to relieve their clinical symptoms and improve their quality of life.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Training of Aerobic Function on Clinical Symptoms and Quality of Life in Patients with Medium and Advanced Lung Cancer

Yan

2022

Journal of Healthcare Engineering

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Objective. To investigate the effects of the training of aerobic function on clinical symptoms and quality of life in patients with medium and advanced lung cancer. Methods. The study objects were 84 patients with medium and advanced lung cancer who were treated in our hospital (July 2019–July 2021) and their materials were retrospectively reviewed. Depending on the different intervention modes, they were equally divided into control group (routine nursing intervention measures) and experiment group (training of aerobic function), with 42 cases in each group. The clinical symptoms and living quality were compared between the two groups. Results. After intervention, affective meaning, behavior/severity, cognitive/mood, and sensory scores in both groups were decreased, and the various indexes in the experiment group were lower compared with the control group (P < 0.05). After intervention, the patients’ clinical symptoms, such as pain, inappetence, insomnia, and dyspnea in the two groups were improved, and the experiment group achieved eminently better improvement compared with the control group (P < 0.05). After intervention, the walking distances in 6 minute walk test (6MWT) in both groups were increased, and the experiment group achieved observably longer walking distance compared with the control group (P < 0.05). After intervention, the patients’ pulmonary function indexes of forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), and FEV1/FVC% level in the two groups were all improved, and the experiment group had signally better indexes compared with the control group (P < 0.05). After intervention, the patients’ scores of Quality of Life Questionnaire-Core Questionnaire (QLQ-C30) in both groups were decreased, and the experiment group achieved much lower score compared with the control group (P < 0.05). Conclusion. The training of aerobic function has obvious therapeutic effect on medium and advanced lung cancer. This training can mitigate the patients’ cancer-related fatigue and clinical symptoms, improve their pulmonary function, and enhance their athletic ability and quality of life.

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Moderate aerobic exercise training ameliorates impairment of mitochondrial function and dynamics in skeletal muscle of high‐fat diet‐induced obese mice

Cited by 22 publications

References 43 publications

Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD

Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD

The impact of diet upon mitochondrial physiology (Review)

Effects of the Training of Aerobic Function on Clinical Symptoms and Quality of Life in Patients with Medium and Advanced Lung Cancer

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