Moderate and severe periodontitis are positively associated with metabolic syndrome

Filho, Isaac Suzart Gomes; Balinha, Izadora da S C E; Cruz, Simone Seixas da; Trindade, Soraya Castro; Cerqueira, Eneida de Moraes Marcílio; Passos‐Soares, Johelle de Santana; Coelho, Julita Maria Freitas; Ladeia, Ana Marice Teixeira; Vianna, Maria Isabel Pereira; Hintz, Alexandre Marcelo; Santana, Teresinha Costa de; Santos, Pedro P Dos; Figueiredo, Ana Cláudia Morais Godoy; Silva, Ivana C O da; Scannapieco, Frank A.; Barreto, Marcos; Loomer, Peter M.

doi:10.1007/s00784-020-03699-2

Cited by 16 publications

(17 citation statements)

References 39 publications

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“…Additionally, it was partially consistent with the study result of Baek et al [44], which showed that the risk of having periodontitis together was also high when three or more were present. Morita et al [19] also found a 2.40 times higher risk of periodontitis in patients with MetS, Campos et al [45] showed a 2.02 times higher prevalence of periodontitis in MetS patients, and a study by Gomes-Filho et al [46] showed approximately 2 times higher probability of having moderate or severe periodontitis in individuals without periodontitis.…”

Section: Discussionmentioning

confidence: 95%

No Association between Metabolic Syndrome and Periodontitis in Korean Postmenopausal Women

Kim

Choi

Chung

2021

IJERPH

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This study aimed to determine the association between metabolic syndrome (MetS) and periodontitis in Korean postmenopausal women. The study selected 3320 menopause women (40–79-year-old) from those who participated in the seventh Korea National Health and Nutrition Survey (2016–2018). This association was determined using frequency and multiple logistic regression analyses. The prevalence of MetS in postmenopausal women was 33.2%, and among the MetS components, abdominal obesity showed a higher odds ratio of periodontitis by 1.36 (95% confidence interval (CI): 1.12–1.65; p < 0.05). The odds ratio for periodontitis was 1.34 times higher (95% CI: 1.12–1.60) in the MetS prevalence group with three or more MetS components (p < 0.05); however, after adjusting for demographic characteristics and health behavior variables, it was not statistically significant. Therefore, our results indicated that MetS has no association with periodontitis in postmenopausal women after adjusting for confounding variables.

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Section: Discussionmentioning

confidence: 95%

No Association between Metabolic Syndrome and Periodontitis in Korean Postmenopausal Women

Kim

Choi

Chung

2021

IJERPH

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“…The bigger effect of this association regarding only severe periodontitis supports studies that only observed this association. Biological plausibility for the inter-relationship between periodontitis and MetS seems to be based by evidence showing the role of immunological markers in serum levels, such as IL-6 and TNF, that interconnect both diseases, in which combined effects have a synergic role on the coexistence of periodontitis and MetS 19,20,26,[44][45][46][47][48] .…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that there is a migration of oral bacteria and byproducts directed to the blood flow, with a systemic dissemination of local inflammatory mediators. Therefore, periodontitis may be able to stimulate 17 inflammatory systemic responses and to contribute with MetS [25][26][27][28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

“…Studies show a positive association between periodontitis and metabolic syndrome 20,26,27,[31][32][33] , varying according to population groups. Thus, the aim of the present study is to investigate the association between periodontitis and metabolic syndrome in patients of a Family Health Unit (FHU) in Vale do Cambonas, in the county of Salvador, Bahia.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Periodontitis and Metabolic Syndrome in a Family Health Unit in Salvador-Ba

Coelho

Ponte

Filho

et al. 2021

Preprint

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Introduction: The metabolic syndrome is characterized by multiple disorders, and the in periodontitis, inflammation occurs in the tissues supporting the tooth, where in this process it is believed that the migration of oral bacteria and byproducts to the circulatory system occurs, with a systemic spread of inflammatory mediators. This study aims to verify the effect of periodontitis on the occurrence of the metabolic syndrome. Method: Cross-sectional study with 90 users of the Family Health Unit from Vale do Cambonas in Salvador-BA. Questionnaires were applied, physical / anthropometric and dental evaluation were performed, record of the results of laboratory tests was registered and evaluation of medical records. Data analysis: A bivariate and stratified analysis was performed, obtaining means and standard deviation for continuous variables, absolute and relative frequency for all variables, and multiple conditional logistic regression was performed to obtain the final model adjusted for potential confounders. Results: In the final sample 46,67% of participants had metabolic syndrome according NECP-ATP III criterion and 30, 00% had periodontitis. From those, 20.00% had severe periodontitis, 10% moderate periodontitis and none with mild periodontitis, according to the criterion proposed by Gomes-Filho et al. (2018). There was statistical significance in the association between periodontitis and MetS (ORcrude = 2.58, 95% CI [1.02 - 6.55]) / (ORadjusted = 2.63, 95% CI [1.01 - 6.80]) and severe periodontitis and MetS (ORcrude = 3.86, 95% CI [1.24 - 11.98]) / (ORadjusted = 4.14, 95% CI [1.29-13.29]). Conclusion: The main findings of this study indicate a positive association between periodontitis and metabolic syndrome, with a higher effect when the exposure was severe periodontitis.

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“…Associations between MetS and dental morbidities have also been documented, including associations with dental caries [6,7] and periodontitis [7][8][9]. Previous studies that analyzed the associations between MetS and dental conditions employed various methods to assess dental outcomes.…”

Section: Introductionmentioning

confidence: 99%

“Dental Cluster” Versus “Metabolic Cluster”: Analyzing the Associations of Planned and Delivered Dental Procedures with Metabolic Syndrome, Utilizing Data from the Dental, Oral, Medical Epidemiological (DOME) Cross-Sectional Record-Based Nationwide Study

Abramovitz

Zini

Pribluda

et al. 2021

Biology

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There are conflicting results existing regarding the association between dental status and metabolic syndrome (MetS). The present research analyzed the associations of the sum of the standard dental unit (SDU) scores of planned (SDU-P) and delivered (SDU-D) dental procedures per patient with MetS components, consequences, and related conditions. The SDU score of each dental procedure represents the time and complexity of the executed procedure. This cross-sectional study analyzed data from the Dental, Oral, Medical Epidemiological (DOME) repository, which includes comprehensive socio-demographic, medical, and dental databases of a nationally representative sample of 132,529 military personnel. Univariate analyses revealed that SDU-P had statistically significant positive associations with all systemic morbidities related to MetS, while the SDU-D exhibited positive associations with some of the systemic morbidities and with lower ORs. SDU-P and SDU-D were associated with worse scores of auxiliary examinations used in the assessment of MetS components. SDU-P retained significant positive associations in the multivariate analysis with impaired glucose tolerance (IGT) (OR = 7.40 (1.91–28.57)), deep vein thrombosis (DVT) (OR = 5.61 (1.53–20.83)), obstructive sleep apnea (OSA) (OR = 5.05 (2.40–10.63)), and fatty liver (OR = 1.82 (1.17–2.84)). In contrast, obesity was the only systemic parameter retaining a significant association with SDU-D following multivariate analysis (OR = 1.47 (1.23–1.76)). It can be concluded that SDU-P, but not SDU-D, is a better predictor of systemic morbidities related to MetS. In other words, MetS is associated with a higher dental treatment needs burden, rather than with dental treatments performed de facto. Dental and general health authorities should collaborate and share information and focus on reducing common health-related risk factors, such as smoking and sugar consumption, in particular among high-risk populations, such as immigrants and those with lower SES and rural locality.

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Moderate and severe periodontitis are positively associated with metabolic syndrome

Cited by 16 publications

References 39 publications

No Association between Metabolic Syndrome and Periodontitis in Korean Postmenopausal Women

No Association between Metabolic Syndrome and Periodontitis in Korean Postmenopausal Women

Association Between Periodontitis and Metabolic Syndrome in a Family Health Unit in Salvador-Ba

“Dental Cluster” Versus “Metabolic Cluster”: Analyzing the Associations of Planned and Delivered Dental Procedures with Metabolic Syndrome, Utilizing Data from the Dental, Oral, Medical Epidemiological (DOME) Cross-Sectional Record-Based Nationwide Study

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