Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects

Martínez‐López, Sara; Sarriá, Beatriz; Mateos, Raquel; Bravo, Laura

doi:10.1007/s00394-018-1726-x

Cited by 92 publications

(99 citation statements)

References 61 publications

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“…Phenolic acid intake was associated only with higher antiinflammatory IL-4. As coffee was the main food contributor of phenolic acids in the HELENA study (12), this corroborates previous findings: IL-4 was positively associated with coffee consumption in rats (43) and tended to be increased by moderate soluble green/roasted (35:65) coffee intake in hypercholesterolemic adults (44).…”

Section: Inflammation and Polyphenol Classessupporting

confidence: 89%

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

Wisnuwardani

Henauw

Ferrari³

et al. 2020

The Journal of Nutrition

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Background Although high dietary polyphenol intake is negatively associated with risk of certain inflammation-associated chronic diseases, the underlying mechanisms are not fully understood and few studies have explored this in adolescents. Objective This study aimed to evaluate the association between intakes of total polyphenols, polyphenol classes, and the 10 most commonly consumed individual polyphenols with inflammatory biomarkers in the blood of European adolescents. Methods In the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study, 526 adolescents (54% girls; 12.5–17.5 y) had data on inflammatory biomarkers and polyphenol intake from 2 nonconsecutive 24-h recalls via matching with the Phenol-Explorer database. Inflammatory biomarkers in serum were IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, transforming growth factor β1 (TGF-β1), TNF-α, IFN-γ, soluble vascular adhesion molecule 1 (sVCAM-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin (sE-selectin), white blood cells, lymphocytes, T cells, and C-reactive protein. Multilevel linear models were used to test associations of polyphenol intake with a pro/anti-inflammatory biomarker ratio [(zTNF-α + zIL-6 + zIL-1)/3/zIL-10] as well as with separate inflammatory biomarkers, adjusted for sociodemographic variables, diet inflammation index, BMI z score, and serum triglycerides. Results The pro/anti-inflammatory biomarker ratio was linearly inversely associated with the intake of total polyphenols (β = −0.11, P = 0.040). When other inflammation biomarkers were considered, the serum IL-10 concentration was inversely associated with total polyphenol (β = −0.12, P = 0.017) and flavonoid (β = −0.12, P = 0.013) intakes, findings that were inconsistent with the biomarker ratio results. However, the anti-inflammatory capacity of polyphenols was confirmed by positive associations of IL-4 with phenolic acid (β = 0.09 P = 0.049) and stilbene (β = 0.13, P = 0.019) intakes and the negative association of IL-1, IL-2, and IFN-γ with lignan intake (β = −0.10, P = 0.034; β = −0.09, P = 0.049; β = −0.11, P = 0.023). Conclusions The negative relation with the overall pro/anti-inflammatory biomarker ratio suggests a potential anti-inflammatory role of high polyphenol intakes among European adolescents. Nevertheless, associations are dependent on polyphenol type and the inflammatory biomarker measured.

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Section: Inflammation and Polyphenol Classessupporting

confidence: 89%

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

Wisnuwardani

Henauw

Ferrari³

et al. 2020

The Journal of Nutrition

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“…In subjects with hypercholesterolemia, daily consumption of a green/roasted coffee blend for 8 weeks increased the levels of total, LDL, and VLDL cholesterol and triglycerides. [ 80 ] Such an effect was not seen in subjects with normal cholesterol levels.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 24 studies were related to cancer ( Table 1 ), [ 17–40 ] and 50 studies to cardiometabolic diseases ( Table 2 ). [ 41–90 ]…”

Section: Methodsmentioning

confidence: 99%

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

Visser

Geleijnse

Roos

2020

Molecular Nutrition Food Res

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Scope: Coffee is associated with a lower risk of cancer, cardiovascular disease, and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption are systematically evaluated. Methods and results: Embase and MEDLINE are searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies meet the inclusion criteria, which report variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. The qualitative analysis shows that sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit the majority of studies have insufficient statistical power to detect significant interaction between these factors and coffee consumption. Conclusion: Several genetic and non-genetic determinants of inter-individual variability in the responses to coffee and caffeine consumption are identified, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects.

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“…In another RCT study by Gavrieli et al, coffee delayed the postprandial glucose response more in females and overweight or obese participants compared to men and participants with normal weight, respectively [127]. A randomized crossover study, where coffee containing green and roasted beans was consumed by 52 volunteers, found decreased levels of lipid markers (LDL-C, VLDL-C, and triglycerides) only in the hypercholesterolemic group (n = 27), but not in the normocholesterolemic one (n = 25) [128]. The same research group also found a decrease in some markers of metabolic syndrome (blood glucose, insulin resistance, and triglycerides) after consumption of green/roasted coffee blend only in hypercholesterolemic subjects [129].…”

Section: Interindividual Variability In Health Responsesmentioning

confidence: 99%

Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

et al. 2019

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Introduction Phenolic acids are important phenolic compounds widespread in foods, contributing to nutritional and organoleptic properties. Factors affceting individual variability The bioavailability of these compounds depends on their free or conjugated presence in food matrices, which is also affected by food processing. Phenolic acids undergo metabolism by the host and residing intestinal microbiota, which causes conjugations and structural modifications of the compounds. Human responses, metabolite profiles and health responses of phenolics, show considerable individual variation, which is affected by absorption, metabolism and genetic variations of subjects. Opinion A better understanding of the gut-host interplay and microbiome biochemistry is becoming highly relevant in understanding the impact of diet and its constituents. It is common to study metabolism and health benefits separately, with some exceptions; however, it should be preferred that health responders and non-responders are studied in combination with explanatory metabolite profiles and gene variants. This approach could turn interindividual variation from a problem in human research to an asset for research on personalized nutrition.

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Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects

Cited by 92 publications

References 61 publications

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?

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