Moderate dietary fat consumption as a risk factor for ischemic heart disease in a population with a low fat intake: a case-control study in Korean men

Suh, Il; Oh, Kyong Eun; Lee, Kang Hee; Psaty, Bruce M.; Nam, Chung Mo; Kim, Suk Il; Kang, Hyung Gon; Cho, Seung Yun; Shim, Won Heum

doi:10.1093/ajcn/73.4.722

Cited by 31 publications

(21 citation statements)

References 25 publications

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“…On the one hand, for some population groups, this aim ( 6 20-30%E) cannot be reached immediately due to their socioeconomic status. On the other hand, an increase in dietary fat intake of 15 to 20-30%E can also have adverse effects [Suh et al, 2001;Bourne et al, 2002;Vorster et al, 2005;Pieters and Vorster, 2008]. For instance, among urban blacks in Africa in the past 50 years, the dietary fat intake was increased from 16.4 to 26.2%E, while the proportion of carbohydrates has decreased from 69.3 to 61.7% of total energy.…”

Section: Dietary Recommendations For Total Fat Intakementioning

confidence: 99%

Fats and Fatty Acid Requirements for Adults

Elmadfa¹,

Kornsteiner²

2009

Ann Nutr Metab

127

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Section: Dietary Recommendations For Total Fat Intakementioning

confidence: 99%

Fats and Fatty Acid Requirements for Adults

Elmadfa¹,

Kornsteiner²

2009

Ann Nutr Metab

127

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“…The prevalence of type II diabetes, obesity, and other metabolic syndromes has remarkably increased not only in developed countries but also in developing countries, which has been considered to be in large part due to an imbalance nutritional status, such as excessive intake of dietary fat (Lichtenstein et al 1998, Suh et al 2001, Donahoo et al 2008. The fetal period is a key developmental window to nutritional exposure, and excessive nutritional intake during this period has been shown to contribute to some features of metabolic disorders, such impacts being independent of postnatal nutritional environment (Chechi & Cheema 2006, Martin-Gronert & Ozanne 2010.…”

Section: Introductionmentioning

confidence: 99%

Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats

Yang

Cai²,

Xu³

et al. 2012

Journal of Molecular Endocrinology

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Maternal high-fat (HF) diets during gestation and lactation have been shown to contribute to metabolic disorders in offspring. Molecular and epigenetic mechanisms underlying this connection may be essential for the prevention and treatment of the fetal origins of metabolic diseases. The current study examined the impact of maternal HF diets on Wnt signaling and histone modification in offspring. Time-pregnant Sprague-Dawley rats were fed either control diet or HF diet during gestation and lactation and then the neonatal offspring of both groups were investigated. The neonatal offspring born to dams fed on HF diets exhibited increases in serum glucose and liver triglyceride levels. Maternal exposure to the HF diet also repressed the mRNA expression of Wnt1 and nuclear b-catenin protein in the liver of offspring. The altered Wnt1 gene expression may be due to the changes of acetylation of H4 at its promoter as well as acetylation of H4 and methylation of H3K9 at coding region. Maternal exposure to the HF diet induced suppression of the Wnt/b-catenin signaling pathway through histone modification, potentially increasing the risk of metabolic syndrome.

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“…There were no associations between total fat and incidence of CHD in the older (55-65 years of age) population of men. A recent study by Suh et al (2001) found a significant association between total fat and IHD in Korean men. After adjusting for IHD risk factors, % en from total fat was positively associated with IHD (odds ratio 1 -08 (95 % CI1-02, 114)).…”

Section: Epidemiological Studiesmentioning

confidence: 92%

“…When examining quartiles of total fat intake and risk of IHD there was a trend for an association between total fat and IHD risk; however, this association did not attain significance until total fat intake (as % total en) was >25%. Suh et al (2001) also examined whether the type of fat affects risk of IHD. In multivariate analyses, when total fat was not controlled for (but IHD risk factors were), SFA intake and MUFA intake were both positively associated with IHD risk (odds ratio 1-15 (95% CI 102, 1-30) for SFA, odds ratio 1-12 (95% CI 101, 1-25) for MUFA).…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Dietary fat: assessing the evidence in support of a moderate-fat diet; the benchmark based on lipoprotein metabolism

et al. 2002

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There is a growing database that has evaluated the effects of varying amounts of total fat on risk factors for cardiovascular disease, diabetes and overweight and obesity. The evidence clearly suggests that extremes in dietary fat should be avoided, and instead a diet moderate in total fat (25-35 % energy) is preferable for the majority of individuals. Moreover, we now appreciate the importance of individualizing dietary fat recommendations within this range of total fat. With respect to cardiovascular disease, a diet higher in total fat (30-35 % energy) affects the lipid and lipoprotein risk profile more favourably than a lower-fat diet; this is also the case for individuals with diabetes, with the added benefit of better glycaemic control. Dietary fibre (>25g/d) attenuates and even prevents the potentially adverse lipid and lipoprotein effects of a lower-fat diet. With respect to weight control, a moderate-fat diet can be as, or even more, effective than a lower-fat diet, because of advantages with long-term adherence and potentially favourable effects on lipids and lipoproteins. Thus, there is now a convincing scientific basis to advocate a diet moderate in total fat for the majority of individuals. Implicit to this position is that unsaturated fat has numerous beneficial health effects. However, because fat is energy dense, moderation in fat intake is essential for weight control. Consequently, a simple message to convey is to avoid diets that are very low and very high in fat. Moreover, within the range of a moderate-fat diet it is still important to individualize the total fat prescription. Nonetheless, the guiding principle is that moderation in total fat is the defining benchmark for a contemporary diet that reduces risk of chronic disease. Moderate-fat diet: Lipoprotein metabolism: Health benefits: Cardiovascular disease:Type 2 diabetes: Weight control

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Moderate dietary fat consumption as a risk factor for ischemic heart disease in a population with a low fat intake: a case-control study in Korean men

Abstract: In a population with a relatively low fat intake (19% of energy intake), a moderate increase in total fat intake may be a risk factor for IHD.

Cited by 31 publications

References 25 publications

Fats and Fatty Acid Requirements for Adults

Fats and Fatty Acid Requirements for Adults

Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats

Dietary fat: assessing the evidence in support of a moderate-fat diet; the benchmark based on lipoprotein metabolism

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