Moderate doses of conjugated linoleic acid isomers mix contribute to lowering body fat content maintaining insulin sensitivity and a noninflammatory pattern in adipose tissue in mice☆

Parra, Pilar; Serra, Francisca; Palou, Andreu

doi:10.1016/j.jnutbio.2008.10.010

Cited by 35 publications

(39 citation statements)

References 50 publications

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“…However, other studies had controversial results, such as the study of Parra et al, 27 these authors demonstrated that the mixture of CLA isomers did not increase insulin resistance in rats given oral supplementation.…”

Section: -Body Weight Gain (A) Weight Of Total Adipose Tissue (B) Ementioning

confidence: 97%

Safflower Oil (Carthamus tinctorius L.) Intake Increases Total Cholesterol and LDL-cholesterol Levels in an Experimental Model of Metabolic Syndrome

Santana

Dutra

Souza

et al. 2017

International Journal of Cardiovascular Sciences

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Section: -Body Weight Gain (A) Weight Of Total Adipose Tissue (B) Ementioning

confidence: 97%

Safflower Oil (Carthamus tinctorius L.) Intake Increases Total Cholesterol and LDL-cholesterol Levels in an Experimental Model of Metabolic Syndrome

Santana

Dutra

Souza

et al. 2017

International Journal of Cardiovascular Sciences

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“…The fat component of bovine milk is on average 3 to 5% of its composition, and most of it is in the form of triacilgliceroids, reported as having bioactivity that results in specific physiological effects [1][2][3][4][5]. One such component is the conjugated linoleic acid (CLA) which chemically refers to various positional and geometric isomers of linoleic acid ( cis-9, cis-12-octadecadienoic acid), for which the two double bonds have a conjugated arrangement instead of methylene interruption.…”

Section: Introductionmentioning

confidence: 99%

Source of Variation of Conjugated-Linoleic-Acid Contents in Dairy Products

Ponte¹

2014

J Food Process Technol

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Samples of bovine milk (raw, thermized, or pasteurized) and of cheeses (raw and pasteurized) at 60 d of ripening were analyzed for contents in CLA. Detected values varied between 1.45 ± 0.20 mg/g in raw milk, 1.44 ± 0.05 mg/g lipid in thermized milk and 1.40 ± 0.11 mg/g in pasteurized milk, and 9.6 ± 0.5 mg/g in pasteurized cheeses and 10.8 ± 4.2 mg/g in raw-milk cheeses. Our results indicate that although processing factors such as heating and ripening affect the CLA contents of a dairy product, the major source of its variation among products may be the intrinsic amount of CLA present in the raw-milk.

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“…Results have shown that c9,t11 and t10,c12 CLA mixtures possess anticancer effects both in vitro and in vivo [2][3][4][5]. Other effects including body composition modulation, atherosclerosis prevention, as well as immune system enhancement, have also been suggested in animal models [6][7][8][9]. CLA isomer enriched diets also effectively reduce body fat and increase lean body mass in several species [7,10,11].…”

Section: Introductionmentioning

confidence: 99%

High Dose trans‐10,cis‐12 CLA Increases Lean Body Mass in Hamsters, but Elevates Levels of Plasma Lipids and Liver Enzyme Biomarkers

Liu

Joseph

Wakefield

et al. 2011

Lipids

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The current study examined the efficacy of graded doses of c9,t11 and t10,c12 CLA isomers on body composition, energy expenditure, hepatic and serum lipid liver biomarkers in hamsters. Animals (n = 105) were randomized to seven treatments (control, 1, 2, 3% of c9,t11; 1, 2, 3% of t10,c12) for 28 days. After 28 days treatment, 1-3% of t10,c12 lowered (p < 0.05) body fat mass compared to the control group. The 1-3% t10,c12 and 3% c9,t11 fed groups showed higher (p < 0.05) lean mass compared to other groups. We observed unfavorable changes in plasma total cholesterol and non-HDL cholesterol levels in animals fed with 3% t10,c12 CLA isomers. The 2%, 3% t10,c12 groups presented elevated (p < 0.05) ALT levels. The present data suggest that a diet enriched with more than 2% t10, c12 led to liver malfunction and poses unfavorable changes on plasma lipid profiles. The 1% t10,c12 CLA lowered (p < 0.05) body fat mass and increased (p < 0.05) lean body mass. The c9,t11 CLA has less potent actions than t10,c12 CLA. We conclude that the actions of CLA on energy and lipid metabolism are form and dose dependent in the hamster model.

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Moderate doses of conjugated linoleic acid isomers mix contribute to lowering body fat content maintaining insulin sensitivity and a noninflammatory pattern in adipose tissue in mice☆

Cited by 35 publications

References 50 publications

Safflower Oil (Carthamus tinctorius L.) Intake Increases Total Cholesterol and LDL-cholesterol Levels in an Experimental Model of Metabolic Syndrome

Safflower Oil (Carthamus tinctorius L.) Intake Increases Total Cholesterol and LDL-cholesterol Levels in an Experimental Model of Metabolic Syndrome

Source of Variation of Conjugated-Linoleic-Acid Contents in Dairy Products

High Dose trans‐10,cis‐12 CLA Increases Lean Body Mass in Hamsters, but Elevates Levels of Plasma Lipids and Liver Enzyme Biomarkers

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