Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients

Véricel, Evelyne; Mazur, Stéphane; Colas, Romain A.; Delaup, V.; Calzada, Catherine; Reix, Philippe; Durieu, I.; Lagarde, Michel; Bellon, G.

doi:10.1016/j.plefa.2016.10.008

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Further studies with diabetic subjects taking moderate daily DHA supplementation (400 mg) have provided results in agreement with those observed in healthy subjects [82]. This protective effect of moderate DHA supplement could also be observed in cystic fibrosis patients [83], where an oxidative stress has clearly been considered as an additional disorder [reviewed in 84]. Figure 3 schematizes the unbalanced platelet situation in presence of protective lipids and those which induce platelet activation.…”

Section: Production and Action Of Oxygenated Pufa Derivatives In Oxidsupporting

confidence: 61%

Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets

Lagarde

Guichardant

Bernoud-Hubac

et al. 2018

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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The oxygenation metabolism of arachidonic acid (ArA) has been early described in blood platelets, in particular with its conversion into the potent labile thromboxane A that induces platelet aggregation and vascular smooth muscle cells contraction. In addition, the primary prostaglandins D and E have been mainly reported as inhibitors of platelet function. The platelet 12-lipoxygenase (12-LOX) product, i.e. the hydroperoxide 12-HpETE, appears to stimulate platelet ArA metabolism at the level of its release from membrane phospholipids through phospholipase A (cPLA) and cyclooxygenase (COX-1) activities, the first enzymes in prostanoid production cascade. Also, 12-HpETE may regulate the oxygenation of other polyunsaturated fatty acids (PUFA) by platelets, especially that of eicosapentaenoic acid (EPA). On the other hand, the reduced product of 12-HpETE, 12-HETE, is able to antagonize TxA action. This is even more obvious for the 12-LOX end-products from docosahexaenoic acid (DHA), 11- and 14-HDoHE. In addition, 12-HpETE plays a key role in platelet oxidative stress as observed in pathophysiological conditions, but may be regulated by DHA with a bimodal way according to its concentration. Other oxygenated products of PUFA, especially omega-3 PUFA, produced outside platelets may affect platelet functions as well.

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Section: Production and Action Of Oxygenated Pufa Derivatives In Oxidsupporting

confidence: 61%

Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets

Lagarde

Guichardant

Bernoud-Hubac

et al. 2018

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Some data suggest the use of glutathione, zinc, vitamin A, vitamin C, and vitamin E may favor the reduction of oxidative stress markers. However, more studies are needed regarding the dosage and the positive effect of their use (30,(35)(36)(37)(38) (level of evidence 5).…”

Section: Is Antioxidant Supplementation Necessary?mentioning

confidence: 99%

Brazilian Guidelines for Nutrition in Cystic Fibrosis

Neri¹,

Simon²,

Ambrósio³

et al. 2022

Einstein (São Paulo)

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Objective: To develop a scientific consensus on nutrition in cystic fibrosis. Methods: Sixteen coordinators elaborated relevant questions on nutritional therapy in cystic fibrosis, which were divided into six sections: nutritional assessment, nutritional recommendations, nutritional intervention, dietary counseling, special situations and enzyme replacement, and gastrointestinal manifestations. Two to three specialists in the field were responsible for each section and obtaining answers formulated based on standardized bibliographic searches. The available literature was searched in the PubMed ® /MEDLINE database, after training and standardization of search strategies, to write the best level of evidence for the questions elaborated. Issues related to disagreement were discussed until a consensus was reached among specialists, based on the current scientific literature. Results: Forty-two questions were prepared and objectively answered, resulting in a consensus of nutritional therapy in cystic fibrosis. Conclusion: This work enabled establishing a scientific consensus for nutritional treatment of cystic fibrosis patients.

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Omega-3 fatty acid supplementation for cystic fibrosis

Watson

Stackhouse

2020

Cochrane Database of Systematic Reviews

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Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients

Cited by 3 publications

References 37 publications

Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets

Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets

Brazilian Guidelines for Nutrition in Cystic Fibrosis

Omega-3 fatty acid supplementation for cystic fibrosis

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