Modern approaches to endometrial receptivity assessment (a review)

Krasnopolskaya, K.V.; Nazarenko, Nazarenko T.A.; Ershova, I.Yu.

doi:10.17116/repro201622561-69

Cited by 10 publications

(3 citation statements)

References 52 publications

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“…The implantation process consists of three main components: hormonal environment, a healthy embryo that should have the ability to implant, and a receptive endometrium. Any abnormality attributed to one of these components may result in unsuccessful IVF attempts [2][3][4]. It is known that the transfer of an embryo without genetic abnormalities after preimplantation genetic screening in many cases does not result a successful pregnancy, which may be due to alteration of endometrial receptivity (ER) or hormonal stimulation [5,6].…”

Section: Introductionmentioning

confidence: 99%

The role of abnormal hypermethylation of the HOXA10 and HOXA11 promoters in implantation failures in IVF programs

Nazarenko

Kalinina

Knyazeva

et al. 2019

Gynecological Endocrinology

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Objective: The objective of this study is to investigate the association between methylation levels of HOXA10 and HOXA11 promoters, clinical parameters, and implantation outcomes after in vitro fertilizationembryo transfer (IVT-ET) cycles in women with repeated implantation failures and tubal infertility. Methods: Endometrium samples were collected from 34 women during implantation window before IVF-ET cycle to assess methylation status of HOXA10 and HOXA11 promoters using bisulfite sequencing. All participants had a tubal factor of infertility and at least two implantation failures in the anamnesis. A logistic regression model was used to predict the implantation outcome depending on methylation status and clinical parameters. Results: The methylation of CpG-islands of HOXA10 and HOXA11 promoters was identified in 76.5 and 100% of participants, respectively. The median methylation levels did not differ significantly between the groups with different implantation outcomes, but a logistic regression model based on HOXA10 and HOXA11 methylation and clinical parameters allowed to classify the implantation outcomes with the total percentage of correct predictions of 85.19%. Conclusions: Abnormal methylation levels of the HOXA10 and HOXA11 promoters were found in the endometrium of women with tubal infertility and repeated implantation failures. The findings suggest that methylation status could be an important factor of implantation failure during IVF-ET cycles.

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Section: Introductionmentioning

confidence: 99%

The role of abnormal hypermethylation of the HOXA10 and HOXA11 promoters in implantation failures in IVF programs

Nazarenko

Kalinina

Knyazeva

et al. 2019

Gynecological Endocrinology

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“…One of the most promising additional methods for diagnosing CE is hysteroscopy [6,16,32,34,65,71], especially in cases of diagnostic uncertainties [70,72,73]. Through visual evaluation of the entire endometrial surface, hysteroscopy can enable the identifi cation of specifi c endometrial changes that are consistent with severe forms (e.g., micropolyps) [73,74].…”

Section: Interpretation Of Resultsmentioning

confidence: 99%

“…A variety of theories are available to explain the CE-related reduction in the implantation capacity of the endometrium [15][16][17][18][19][20] -activation of local infl ammatory processes with altered secretion of cytokines and chemokines [19,[21][22][23][24][25]; abnormal leukocytic infi ltration, decidualization, and vascularization in the uterine cavity mucosa [13,19,23,24,26,27,29,30]; altered uterine contractility [16,28]. Although these theories clearly refl ect some features of CE pathogenesis, the current evidence for a correlation between this pathology and implantation defects is often based on data from studies that are not without their limitations, such as heterogeneous sampling and questionable diagnostic criteria for CE [31,32].…”

Section: Introductionmentioning

confidence: 99%

Chronic endometritis and infertility — in vitro fertilization outcomes: systematic review and meta-analysis

Lokshin,

Kutsenko,

Borovikov

et al. 2023

Kuban. nauсh. med. vestnik

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Background. The relevance of the problem is related to the high prevalence of chronic endometritis (CE); its role in female infertility, implantation failures during assisted reproductive technology procedures, and recurrent miscarriage; as well as the lack of a unified strategy in the diagnosis and treatment of this pathology. The present systematic review with a meta-analysis focuses on evaluating the impact of CE and its therapy on the outcome of in vitro fertilization. In addition, the effect of CE of various severity on the outcomes of assisted reproductive technologies is analyzed. Objective. To analyze the effect of CE of varying severity and its treatment on the outcomes of in vitro fertilization. Methods. Using PubMed, Medline, Scopus, Embase, ELibrary, Cochrane Central Register of Controlled Trials (CENTRAL), WHO International Clinical Trials Registry, and Russian Science Citation Index, a systematic search was conducted for articles published over the past 12 years that met the following criteria: randomized controlled trial examining the effect of CE of varying severity on fertility and ways to treat it. The following indicators were calculated: ongoing pregnancy/live birth, clinical pregnancy, and miscarriage rates. A total of 4145 patients (from ten studies) were included. A meta-analysis was performed using Stata 11.0 software (The Cochrane Collaboration, Oxford, UK). The heterogeneity was considered low at I2 <30%, moderate at 30–50%, and high at >50%. Results. Women with CE exhibited lower ongoing pregnancy/live birth (OR 1.97; p = 0.02) and clinical pregnancy rates (OR 2.28; p = 0.002) as compared to women without it. CE treatment increased the ongoing pregnancy/live birth (OR 5.33; p < 0.0001) and clinical pregnancy rates (OR 3.64; p = 0.0001). In vitro fertilization outcomes were comparable in women treated for CE and women without CE (ongoing pregnancy/live birth rate, clinical pregnancy rate, and miscarriage rate: p = ns). Women with severe CE exhibited lower ongoing pregnancy/live birth (OR 0.43; p = 0.003) and clinical pregnancy rates (OR 0.40; p = 0.0007). Mild CE showed no significant effect on in vitro fertilization outcomes (ongoing pregnancy/ live birth rate, clinical pregnancy rate, and miscarriage rate: p = ns). Conclusion. The conducted meta-analysis showed that CE significantly reduces the ongoing pregnancy/live birth and clinical pregnancy rates in infertile women undergoing in vitro fertilization. Noteworthy is that antimicrobial therapy in such patients improves the results of assisted reproductive technologies, which are comparable to those of patients without CE. The negative impact of this pathology on the implantation capacity of the endometrium is most often observed in the severe form, while its mild form has virtually no effect on the in vitro fertilization outcome.

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The effectiveness of micronized progesterone in the complex therapy of ‘thin endometry’ syndrome

Мамедалиева¹,

Kurmanova²,

Baikoshkarova³

et al. 2021

Gynecological Endocrinology

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Modern approaches to endometrial receptivity assessment (a review)

Cited by 10 publications

References 52 publications

The role of abnormal hypermethylation of the HOXA10 and HOXA11 promoters in implantation failures in IVF programs

The role of abnormal hypermethylation of the HOXA10 and HOXA11 promoters in implantation failures in IVF programs

Chronic endometritis and infertility — in vitro fertilization outcomes: systematic review and meta-analysis

The effectiveness of micronized progesterone in the complex therapy of ‘thin endometry’ syndrome

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