Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma

Deckert, Martina; Engert, Andreas; Brück, Wolfgang; Ferreri, Andrés J.M.; Finke, Jürgen; Illerhaus, Gerald; Klapper, Wolfram; Korfel, Agnieszka; Küppers, Ralf; Maarouf, Mohammad; Montesinos‐Rongen, Manuel; Paulus, Werner; Schlegel, Uwe; Lassmann, Hans; Wiestler, Otmar D.; Siebert, Reiner; DeAngelis, Lisa M.

doi:10.1038/leu.2011.169

Cited by 166 publications

(139 citation statements)

References 96 publications

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“…We report an extremely rare case that PCNSLs were located both in lateral and fourth ventricle. According to review of literature, PCNSLs are mostly located in the brain hemisphere (38%), thalamus/basal ganglia (16%), corpus callosum (14%) and peri-ventricular regions (12%) (5), with a single tumor in 60-70% of patients and multiple in the remainder (4). For tumors in the fourth ventricle, medulloblastoma (commonly in chidhood), ependymoma and astrocytoma is most frequent (11).…”

Section: Zhu Y Et Al: Multifocal Ventricular Primary Cns Lymphoma DImentioning

confidence: 99%

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Multifocal lateral and fourth ventricular primary cns lymphoma: case report and literature review

Zhu¹,

Yao²,

Zhan³

et al. 2014

Turkish Neurosurgery

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We report a 66-year-old man with 2-month history of dizziness and 1-month history of diplopia. Cranial magnetic resonance imaging (MRI) disclosed two solid masses, one in the right lateral ventricle and another in the fourth ventricle. A surgical biopsy was performed on the basis of safety. The diagnosis of large B-cell lymphoma was made postoperatively. The patient recovered without additional deficits and was then commenced on chemotherapy and remained well 6 months after the diagnosis. Primary B-cell lymphomas should always be included in the list of differential diagnosis of intraventricular tumors. Here we report an extremely rare case of primary central nervous system lymphoma with multifocal ventricular involvement. KEywords: Primary CNS lymphoma, Multifocal, Cerebral ventricle neoplasms ÖZİki aylık baş dönmesi ve 1 aylık çift görme öyküsü olan 66 yaşında bir erkek hasta sunuyoruz. Kraniyal manyetik rezonans görüntüleme (MRG), biri sağ lateral ventrikül ve diğeri dördüncü ventrikülde olmak üzere iki solid kitle gösterdi. Emin olmak için cerrahi biyopsi yapıldı. Postoperatif olarak büyük B hücreli lenfoma tanısı kondu. Hasta ek bir defisit olmadan iyileşti ve kemoterapiye başlandı. Hasta tanıdan 6 ay sonra iyi durumdadır. Primer B hücreli lenfomalar intraventiküler tümörlerin ayırıcı tanısında daima dikkate alınmalıdır. Burada multifokal ventriküler tutulumlu çok nadir bir primer merkezi sinir sistemi lenfoma olgusu sunuyoruz.

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Section: Zhu Y Et Al: Multifocal Ventricular Primary Cns Lymphoma DImentioning

confidence: 99%

“…The standard treatment for PCNSL is biopsy followed by systemic chemotherapy with or without whole brain radiotherapy or intrathecal chemotherapy (4,5). Here we report a case of PCNSL located in both lateral and fourth ventricles and that was successfully diagnosed by surgical exploration and biopsy.…”

Section: Introductionmentioning

confidence: 99%

Multifocal lateral and fourth ventricular primary cns lymphoma: case report and literature review

Zhu¹,

Yao²,

Zhan³

et al. 2014

Turkish Neurosurgery

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“…Der Allgemeinzustand des Patienten(Immunsuppression,Immunkompetenz,die Anzahl und ArtderweiterenErkrankungen) ist ebenfalls wichtig. Jeder Patient sollte vor der Behandlung in einem multidisziplinären Team detailliert besprochen werden [61,62,63,64,65,66,67,68,69]. Häufig werden die Patienten nach lokalem oder nationalem Protokoll therapiert, da es bislang keinen internationalen Konsensus hinsichtlich der Therapieempfehlungen gibt.…”

Section: Therapie Der Primären Vitreoretinalen Lymphomeunclassified

“…Im Rahmen dieses Beitrags ist es nicht möglich, einen vollständigen systematischen Überblick der Therapien der PVRL (und der PZNSL) zu erstellen. Daher wird auf die weitere Literatur verwiesen [9, 61,62,64,65,66,67,68].…”

Section: Therapie Der Primären Vitreoretinalen Lymphomeunclassified

Primäre vitreoretinale Lymphome

Jaehne

Coupland

2018

Ophthalmologe

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“…Central nervous system lymphoma (CNSL) arises as primary CNS lymphoma (PCNSL) -a lymphoma that is confined to the CNS at time of diagnosis -or as secondary CNS involvement of systemic lymphoma (SCNSL) [1][2][3]. The diagnosis is typically based on contrast-enhanced cranial magnetic resonance imaging and histopathological confirmation by a biopsy from a CNS lesion [4].…”

Section: Introductionmentioning

confidence: 99%

Osteopontin in cerebrospinal fluid as diagnostic biomarker for central nervous system lymphoma

et al. 2016

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Central nervous system lymphoma (CNSL) is diagnostically challenging. The identification of reliable and easy to measure biomarkers is desirable to facilitate diagnosis. Here, we evaluated the value of cerebrospinal fluid (CSF) osteopontin (OPN) as a diagnostic biomarker for CNSL. OPN concentrations in CSF from 37 patients with CNSL (29 with primary CNSL and 8 with secondary CNS involvement of systemic lymphoma) and 36 controls [6 patients with inflammatory CNS disease other than multiple sclerosis (MS), 8 with MS, 9 with glioblastoma (GBM) and 13 healthy controls] were determined using an enzyme-linked immunosorbent assay. Non-parametric tests and receiver operating characteristic (ROC) curves were performed for determination of diagnostic accuracy. Median CSF OPN level in all CNSL patients was 620 ng/mL and higher than in patients with inflammatory CNS disease (356 ng/mL); P < .05, MS (163 ng/mL); P < .01, GBM (41 ng/mL); P < .01, or healthy controls (319 ng/mL); P < .01. The area under the ROC curve was 0.865 [95 % confidence interval (CI) 0.745-0.985] for differentiating CNSL and patients with inflammatory CNS disease; 0.956 (95 % CI 0.898-1.000) for CNSL and MS patients; 0.988 (95 % CI 0.964-1.000) for CNSL and GBM patients, and 0.915 (95 % CI 0.834-0.996) for CNSL patients and healthy controls. In multivariate analysis, high CSF OPN level was associated with shorter progression-free (HR 1.61, 95 % CI 1.13-2.31; P = .009) and overall survival (HR 1.52, 95 % CI 1.04-2.21; P = .029). CSF OPN is a potential biomarker in CNSL.

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Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma

Cited by 166 publications

References 96 publications

Multifocal lateral and fourth ventricular primary cns lymphoma: case report and literature review

Multifocal lateral and fourth ventricular primary cns lymphoma: case report and literature review

Primäre vitreoretinale Lymphome

Osteopontin in cerebrospinal fluid as diagnostic biomarker for central nervous system lymphoma

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