Modern etiotropic therapy of HIV infection and concomitant herpes virus diseases in children

Timchenko, V. N.; Yastrebova, E. B.; Булина, О. В.; Выжлова, Е.Н.

doi:10.20953/1729-9225-2017-2-25-32

Cited by 4 publications

(1 citation statement)

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“…У 3 диагностирована стадия 4А, у 1 -стадия 4В ВИЧ-инфекции. У всех детей данной группы установлено перинатальное инфицирование, с момента постановки диагноза они получали АРВТ в соответствии с Клиническими рекомендациями МЗ РФ, 2017 г. Клинические симптомы, состояния и заболевания у детей с ВИЧ-инфекцией у каждого ребенка в отдельно взятый промежуток времени могут быть различными [2,3,5,16,19]. Среди них выделяют специфические для ВИЧ-ин фицированных детей (пневмоцистную пневмонию, кандидоз пищевода, лимфоидную интерстициальную пневмонию, герпес-зостер-вирусную инфекцию с поражением нескольких дерматомов, саркому Капоши и др.)…”

Section: результаты и обс у ж дениеunclassified

Contemporary diagnosis of HIV infection in pediatrician’s practice

Hakizimana

Жан-Клод²,

Ivanov

et al. 2020

Pediatr (SPb)

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The objective of the study: evaluation of the effectiveness of clinico-epidemiological and laboratory diagnostics of HIV infection in pediatric practice. Materials and methods. Under the supervision of pediatricians of the Department of motherhood and childhood of the St. Petersburg AIDS Center, there were 388 HIV-infected children aged from one month to 17 years inclusive. Due to the reasons of late detection and HIV dissidence of parents, 18 children (4%) died cumulatively among the children observed in St. Petersburg center for AIDS. The object of the immunohistochemical study was randomly selected HIV-infected children who applied to the center for prevention and control of AIDS for return visits. Material for testing for the presence of HIV-1 P24 antigen was taken from the back wall of the nasopharynx. Results. When analyzing the ways of HIV infection in children registered at the maternity and childhood Department of the Saint Petersburg AIDS Center, it turned out that 363 children were infected perinatally (93,6%), 23 (5,9%) sexually infected and 2 children through injecting drugs (0.5%). The proposed method of immunocytochemistry for the diagnosis of HIV infection in children can find its application, especially for primary diagnostics, which may simplify and reduce the cost of laboratory diagnostics.

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Section: результаты и обс у ж дениеunclassified

Contemporary diagnosis of HIV infection in pediatrician’s practice

Hakizimana

Жан-Клод²,

Ivanov

et al. 2020

Pediatr (SPb)

View full text Add to dashboard Cite

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Features of the course and therapy of HIV infection in children at different stages of the disease

Hakizmana

Yastrebova

Timchenko

et al. 2020

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Independent predictors of forecasting the course of congenital HIV infection in children

Денисенко

Симованьян

2021

Det. infekc.

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The purpose is to characterize the clinical and laboratory parameters in children with different rates of congenital HIV infection progression and, based on the data obtained, to develop independent predictors of forecasting the course of the disease.Research methods. The comparison of clinical, immunological and virological parameters in 91 children with HIV infection with rapid (26%) and slow progression of the disease (74%) was carried out. The criterion for the rapid progression of HIV infection was considered the development of the AIDS clinic in the first two years of life.Results. Testing of clinical, immunological and virological parameters in a multivariate logistic regression model revealed independent predictors of rapid progression in children aged 6 months — HIV blood viral load more than 1 00 000 cop./ml (odds ratio OR 23.9; 95% confidence interval 95% CI 4.6—71.8; P < 0.001) and a decrease of blood CD4-lymphocytes less than 25% (OR 6.3; 95% CI 1.2—33.4; P = 0.029). The predictor «HIV blood viral load more than 100 000 cop./ml» was characterized by a higher sensitivity (91.3%), specificity (97.1 %) compared to the indicator «CD4 lymphocyte count less than 25%» (88.2% and 86.9%).Conclusion. In 26% of children with HIV infection, there is a rapid progression of the disease with the development of AIDS clinic during the first two years of life. The independent predictors of forecasting an unfavorable course of the disease are HIV blood viral load of more than 1 00 000 cop./ml and a decrease in CD4 lymphocytes in the blood of less than 25% at the age of 6 months. The level of viremia seems to be more preferable for predicting the course of HIV infection in children due to its high sensitivity and specificity.

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Modern etiotropic therapy of HIV infection and concomitant herpes virus diseases in children

Cited by 4 publications

References 0 publications

Contemporary diagnosis of HIV infection in pediatrician’s practice

Contemporary diagnosis of HIV infection in pediatrician’s practice

Features of the course and therapy of HIV infection in children at different stages of the disease

Independent predictors of forecasting the course of congenital HIV infection in children

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