Modern kinetic spectrophotometric procedure for estimation of furosemide drug as bulk form and in pharmaceuticals preparations

Abstract

A simple, rapid, sensitive, inexpensive and easy to perform kinetic spectrophotometric procedure for the investigation of trace quantities of the drug, furosemide (FRO), as bulk and in the pharmaceutical preparations, has been improved upon. The enhanced method was depended on the fashioning of the Schiff ‘s base by the reaction of the aldehyde group present in the 5-sulfo salicylaldehyde reagent, and the primary amino group present in furosemide. The latter acts as a ligand for the formation of an intense colored complex with Co(II) in an acidic medium, with maximum absorption at 608 nm. In the work, kinetic spectrophotometrics were established through the fixed time method. Moreover, Beer’s law was applied on the range of concentration between 5-100 ppm, while the molar absorptivity and the Sandell sensitivity were 3.9295×104 l.mol−1cm−1, 0.008 μg.cm−2, respectively. The detection limit (LOD) was 2.133 µg/ml−1, and LOQ was 1.105 µg/ml−1. Ideal circumstances for all colour improvement were seen, and the suggested procedure has been effectively employed in investigating amounts of furosemide (FRO) in bulk forms and in pharmaceutical preparations (tablets, injection sample). Additives and general excipient materials did not affect the studied method. A statistical comparison between the results that were obtained from the reference method gave good agreement.

Validated stability Spectrophotometric process for estimation vancomycin antibiotic degradation behavior in pharmaceutical kinds

“…For the repeatability analysis, six specimens of tablet formulations were analyzed. Calculation of standard deviation and RSD percentage [32,33].…”

“…Separate orders of attachment of reagents were investigated and it was observed that the sequence of introduction of materials by combining drug and acid hydrochloride with ceric ammonium nitrate after 25min methyl blue solution that provided the strongest absorption after 5min and was used in certain ensuing tests [32].…”

Spectrophotometric determination of metoclopramide medicine in bulk form and in pharmaceuticals using orcinol as reagent

“…Each of the studied excipients was given independently by ten-times concentrations more than of MCP prepared by the self-approach in the calibration curve. 1 ml of 500 ppm MCP and 1 ml of every excipients were connected for the study of interferences [21]. Dilution to the sign of volumetric flask 25 ml grade of impedance was made.…”

Evolution and Effectiveness of Colormetric Approach for Investigation of Ceftriaxone Medicine as in Pure Form and in Formulation Vials

“…3 (2). [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] J. Islamic Pharm., an open access journal ISSN : 2527-6123 administration. Urinary excretion is the major elimination pathway for ceftriaxone sodium.…”