Modern methods of diagnosing chronic kidney disease in patients with diabetes mellitus

Markova, T. N.; Николаевна, Маркова Татьяна; Sadovskaya, Viktoriia V.; Викторовна, Садовская Виктория; Bespyatova, Marina Y.; Юрьевна, Беспятова Марина

doi:10.14341/dm9268

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…It was proposed to use cystatin C detection to identify patients at high risk of chronic kidney disease (CKD) [7], [9]. For the early diagnosis of CKD and detection of renal damage, it has also been proposed to use neutrophil gelatinaseassociated lipocalin (NGAL) -specific protein, the level of which in blood plasma or urine gradually increases during the development of renal dysfunctions [10], [11]. NGAL has been shown to be effective in the early diagnosis of acute kidney injury (AKI) in various clinical settings [12], [13], [14].…”

Section: Kazakhstan Ranks 34mentioning

confidence: 99%

The Role of Serum Neutrophil Gelatinase-associated Lipocalin in the Early Diagnosis of Nephropathy in Patients with Acute Alcohol Poisoning

Демидчик¹,

Klyuyev²,

Muravlyova³

et al. 2020

Open Access Maced J Med Sci

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AIM: In our study, we assessed the possibility of using the serum neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of kidney damage in patients with acute alcohol poisoning (AAP). METHODS: The study included 89 patients and 30 healthy donors. All participants in the study were mostly represented by men (90%) aged between 20 and 40 years. The influence of alcohol poisoning severity was also taken into account in the study. The Human NGAL ELISA Kit was used for the quantitative detection of serum NGAL. We also evaluated the main laboratory indicators of kidney functions, including eGFR (calculated according to serum creatinine). RESULTS: We did not find a correlation between blood alcohol concentration and serum NGAL level; also, alcohol poisoning severity did not affect the NGAL values. The results of our study showed the possibility of using the serum NGAL in patients with AAP to detect the preclinical stage of reduced renal function, until the moment when it can be diagnosed with using only serum creatinine. CONCLUSION: We propose to consider an increase in eGFR together with an increase in serum NGAL in this group of patients as a stage, preceding nephropathy, even in the absence of clinical and laboratory signs of impaired renal function.

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Section: Kazakhstan Ranks 34mentioning

confidence: 99%

The Role of Serum Neutrophil Gelatinase-associated Lipocalin in the Early Diagnosis of Nephropathy in Patients with Acute Alcohol Poisoning

Демидчик¹,

Klyuyev²,

Muravlyova³

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…It was proposed to use cystatin C detection to identify patients at high risk of chronic kidney disease (CKD) (5,7). For the early diagnosis of diabetic nephropathy and detection of renal damage it has also been proposed to use neutrophil gelatinase-associated lipocalin (NGAL), the level of which in plasma or urine gradually increases during the development of renal dysfunctions (8)(9)(10). NGAL is a proven and preferred marker of acute kidney injury (AKI) in various clinical settings (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Serum neutrophil gelatinase-associated lipocalin and oxidized neutrophil proteins in patients with nephropathy caused by acute alcohol poisoning

et al. 2021

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This study has implication for practical medicine, public health and scientific community because it considers the issue of the possibility of using the serum neutrophil gelatinase-associated lipocalin (NGAL) and oxidized neutrophil proteins for the early detection of kidney damage in patients with acute alcohol poisoning, until the moment when it can be diagnosed with using only serum creatinine. Additionally, in this study we compared these indexes at toxic nephropathy and early stages of chronic kidney disease, having revealed opposite trends in their changes.

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Serum Neutrophil Gelatinase Associated Lipocalin in Patients with Toxic Nephropathies. Prospective Study

et al. 2021

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Background. Drug induced kidney disorder (DIKD) is a frequent adverse event which contributes to morbidity and even incapacitation. Toxic nephropathy also is one of the pathological syndromes or complications in acute alcohol poisoning (AAP). Recent years experience shows the insensitivity of serum creatinine to the early stages of kidney damage. NGAL has been shown as a preferred marker of acute kidney damage in a variety of clinical settings. However, no similar studies of serum NGAL have been performed in patients with toxic nephropathy. The presence of markers discovers the possibility of earlier detection, timely treatment and prevention of disease progression to chronic kidney disease (CKD), which can improve the patients prognosis. Aims to study serum NGAL levels in patients with AAP and DIKD with clinically diagnosed nephropathy and without signs of kidney damage. The effect of glomerular filtration rate (GFR) on serum NGAL levels was studied. Materials. This prospective cross-sectional study was conducted on the basis of the biochemical laboratory of the Karaganda Medical University in conjunction with the toxicological department of the Regional Medical Center (from January 2018 to October 2019). The study included 89 patients with AAP and 50 patients with DIKD. 25 healthy donors (control group) and 25 patients with CKD served as comparison groups. Serum NGAL levels were measured using a commercially available ELISA kit. Results. We detected the increased serum NGAL level in both groups with drug-induced nephropathy and nephropathy, caused by AAP compared with the control group values (p 0.01). However, there were no significant differences in NGAL level, depending on the type of toxic nephropathy. After ranking the GFR, it was revealed that GFR did not affect the serum NGAL level (F = 2.21; p = 0.12) and its increase was observed both at reduced and increased GFR relative to the control group values (p 0.05). Conclusions. The results of our study showed a multiple increase in the concentration of NGAL in serum not only in patients with toxic nephropathy, but also in patients with increased GFR, even in the absence of clinical and laboratory signs of impaired renal function.

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Modern methods of diagnosing chronic kidney disease in patients with diabetes mellitus

Cited by 6 publications

References 31 publications

The Role of Serum Neutrophil Gelatinase-associated Lipocalin in the Early Diagnosis of Nephropathy in Patients with Acute Alcohol Poisoning

The Role of Serum Neutrophil Gelatinase-associated Lipocalin in the Early Diagnosis of Nephropathy in Patients with Acute Alcohol Poisoning

Serum neutrophil gelatinase-associated lipocalin and oxidized neutrophil proteins in patients with nephropathy caused by acute alcohol poisoning

Serum Neutrophil Gelatinase Associated Lipocalin in Patients with Toxic Nephropathies. Prospective Study

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