Aiming to intercept high-speed maneuvering targets, nonlinear model was established and relative dynamic equations between the interceptor and the target were analyzed. An omni-directional true proportional navigation (OTPN) guidance law was developed. In high-speed target interception, OTPN guidance law has a wide capture region and can automatically shift interception mode. Formulary analysis proved that target maneuver has no effect on the expression form of OTPN guidance law. Without any additional conditions, OTPN guidance law can meet the requirement to intercepting high-speed maneuvering targets. Numerical simulation results showed that OTPN guidance law can effectively intercept high-speed maneuvering targets and its capture region is influenced by targets' maneuver ability and initial LOS angle. The parameters of OTPN, such as capture region, ballistic characteristics, and overload variation and control efforts, show that OTPN are superior to traditional guidance schemes.