Modern  Opportunities  in Uveitis Treatment

Krakhmaleva, D.A.; Pivin, Edward; Trufanov, S.V.; Malozhen, S A

doi:10.18008/1816-5095-2017-2-113-119

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Однако в ряде случаев инициируется выработка провоспалительных цитокинов (IL-2, IL-12, TNF-α, INF-γ и др. ), в результате действия которых наступает структурно-функциональная дезорганизация соединительной ткани, нарушается микроциркуляция, что обусловливает появление гипоксии, ишемии и множества других изменений в тканях глаза, способствуя развитию внутриглазных осложнений [15,16]. Диагностировать подобные иммунологические реакции в глазной жидкости практически невозможно.…”

Section:  обсуждениеunclassified

Detection of Torque Teno Virus in Intraocular Fluid in Inflammatory Diseases of the Choroid

Марченко,

Егоров,

Семёнов

et al. 2023

Клиническая Инфектология И Паразитология

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Целью исследования являлось определение наличия ДНК Torque teno virus (TTV, ТТ-вирус) во внутриглазной жидкости (ВГЖ) у пациентов с различными формами воспаления сосудистой оболочки глаза. В данное исследование было включено 18 пациентов (8 мужчин и 10 женщин) в возрасте от 37 до 92 лет. Участники исследования проходили стационарное лечение с воспалительными заболеваниями сосудистой оболочки глаза, девяти из них было ранее проведено хирургическое лечение по поводу катаракты с имплантацией интраокулярной линзы. У включенных в исследование забирались образцы ВГЖ с помощью процедуры парацентеза передней камеры. В полученных образцах осуществлялось обнаружение ДНК TTV с использованием полимеразной цепной реакции в режиме реального времени. ДНК TTV была обнаружена в 12 (66,7%) из 18 образцов водянистой влаги. Частое обнаружение TTV в ВГЖ рождает гипотезу о том, что TTV может быть фактором риска, маркером или патогеном, вызывающим генерализованное воспаление сосудистой оболочки глаза. The purpose of the study was to determine the presence of Torque teno virus (TTV) DNA in the intraocular fluid in patients with various forms of inflammation of the choroid. This study included 18 patients (8 men and 10 women) aged 37 to 92 years. The participants of the study were hospitalized with inflammatory diseases of the choroid, nine of them had previously undergone cataract removal with intraocular lens implantation. Samples of intraocular fluid were taken by using an anterior chamber paracentesis procedure. After that, TTV DNA was detected by using real-time polymerase chain reaction. TTV DNA was detected in 12 (66.7%) of 18 aqueous humor samples. The frequent detection of TTV in the intraocular fluid gives rise to the hypothesis that TTV may be a risk factor, marker or pathogen causing generalized inflammation of the choroid.

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Section:  обсуждениеunclassified

Detection of Torque Teno Virus in Intraocular Fluid in Inflammatory Diseases of the Choroid

Марченко,

Егоров,

Семёнов

et al. 2023

Клиническая Инфектология И Паразитология

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“…Ocular inflammation can result in reduced visual acuity and even blindness, and affects functional work capacity and quality of life, posing a social and economic challenge for the society. Therefore, finding means for improving the effectiveness of drug therapy of ocular inflammatory disorders, especially those with comorbidities, is a challenge for clinical ophthalmologists [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Etiotropic and pathogenetic therapy for uveitic inflammatory processes involves immunosuppressive, steroidal and non-steroidal anti-inflammatory agents [2][3][4]. Corticosteroids and non-steroidal anti-inflammatory agents, although adequately effective, can result in metabolic abnormalities or even glaucoma and cataract, when applied for a long period [5].…”

Section: Introductionmentioning

confidence: 99%

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Effects of carnosine on the pro-antioxidative status of the anterior segment in experimental uveitis plus ocular hypertension

Mikheytseva¹,

Bondarenko²,

Kolomiichuk³

2022

Oftalmol Zh

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Background: Finding means for improving the effectiveness of drug therapy of ocular inflammatory disorders, especially those with comorbidities, is a challenge to ophthalmology. Purpose: To assess the efficacy of carnosine for improving the pro/antioxidative imbalance in the anterior segment of rabbit eyes with experimental anterior uveitis in the presence of ocular hypertension (OHT). Material and Methods: Thirty-three rabbits were used in the study. Group 1 (the control group) comprised 9 intact rabbits and group 2, 12 animals with OHT induced prior to experimental non-infectious uveitis. Group 3 comprised 12 animals in which carnosine 5% was administered bilaterally into the conjunctival sac twice daily for four weeks for OHT induced prior to experimental non-infectious uveitis. Non-infectious uveitis was induced by injecting albumin into the anterior chamber, and OHT was induced by a single 0.1-mL injection of carbomer 0.3% into the anterior chamber. Activities of superoxide dismutase, catalase, glutathione peroxidase, NADH-oxidase and xanthine oxidase, and levels of total proteins and malondialdehyde (MDA) and diene conjugate (DC) in uveal tissue (iris and ciliary body) and aqueous humor specimens were determined. Results: Uveal activities of NADH-oxidase and xanthine oxidase were 19.4% (р < 0.05) and 27.2% (р < 0.01), respectively, lower in eyes of rabbits treated with carnosine than in eyes of animals not treated for anterior uveitis plus OHT. Uveal activities of glutathione peroxidase, superoxide dismutase and catalase were 34. 7%, 39.6% and 28.4%, respectively, higher, and uveal MDA and DC levels were 39.3% and 33.3%, respectively, lower, in eyes of the former rabbits than of the latter rabbits. Similar changes were found in aqueous humor specimens of the experimental rabbits. Conclusion: Carnosine, when instilled locally, contributed to improvement in the pro/ antioxidative imbalance in the anterior segment of rabbit eyes with uveitis plus OHT. It is reasonable to include carnosine-based eye drops into multiagent therapy of uveitis complicated by OHT due to their antioxidative, anti-inflammatory and membranestabilizing effects.

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“…Presently available medications for the treatment of uveitis have significant side effects as well as a low efficacy to prevent complications of ocular inflammation, including ocular inflammation with ocular hypertension (OHT). The pathogenetic mechanisms of these conditions and a potential for an increase in efficacy-to-side effect ratio [26,27] should be taken into account in order to reduce the rate and amount of the phenomenon. Because of this, in our studies we used the naturally occurring dipeptide carnosine (beta-alanyl-L-histidine), an anti-oxidant that has been shown to exhibit biological effects on the ocular structures in the treatment of various inflammatory and degenerative disorders [28], to assess its effect on the level of neopterin as a marker of the degree of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Neopterin level in the anterior segment of the eye in induced uveitis with ocular hypertension when treated by dipeptide carnosine

Mykheitseva¹,

Si²,

Бондаренко³

et al. 2021

Oftalmol Zh

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Background:We have previously demonstrated that the course of inflammatory process was significantly more severe in eyes with anterior uveitis with ocular hypertension (OHT) than in those with anterior uveitis with normal intraocular pressure (IOP), which was largely due to a more marked activation of enzymes producing active oxygen as well as peroxidative processes in uveal structures of experimental animals. Aside from oxidative stress characteristics, our attention has been drawn to neopterin as a potential marker of inflammation severity and the efficacy of inflammation control. Because there is a paucity of reports focused on the potential for using this characteristic as a diagnostic criterion in ocular disorders, especially in uveitis with raised IOP, studies on this subject are important. Purpose: To assess the impact of dipeptide carnosine on the level of neopterin in the rabbit's anterior eye segment in anterior uveitis with ocular hypertension. Material and Methods: Forty-four Chinchilla rabbits (88 eyes) were divided into 4 experimental groups (group 1, 10 animals with induced OHT only; group 2, 10 animals with induced experimental non-infectious uveitis only; group 3, 12 animals with OHT induced prior to experimental non-infectious uveitis; group 4, 12 animals treated with carnosine for experimental uveitis with OHT). Rabbits of group 4 received 5% carnosine solution into the conjunctival sac, twice daily for the four weeks. The control group comprised 9 intact rabbits. Neopterin enzyme-linked immunosorbent assay kit was used to determine neopterin levels in uveal tract tissue, aqueous humor and tear samples according to the manufacturer's instructions. Statistica 5.5 (StatSoft, Tulsa, OK, USA) software and parametric statistical tests were used for statistical analysis. Results: Neopterin levels in uveal tract tissue, aqueous humor and tear samples taken from rabbit's eyes with induced OHT only were increased compared to controls but lower than those in non-infectious uveitis only. Neopterin levels in uveal tract tissue, aqueous humor and tear samples from rabbit's eyes with induced both anterior uveitis and OHT (group 3) were 5. 2-, 3.7-and 2.4 times higher, respectively, than in controls, and 42.5% (р < 0.05), 28.5% (р < 0.05) and 23.6% (р < 0.05) higher, respectively, than in samples taken from rabbit's eyes of group 2. The carnosine treatment of induced both anterior uveitis and OHT (group 4) contributed to reduced levels of neopterin is samples under study, with neopterin levels in uveal tract tissue, aqueous humor and tear fluid being 39.4%, 38.9% and 30.2% lower, respectively, than in samples taken from rabbit's eyes of group 3 (anterior uveitis plus OHT without treatment) (р < 0.01), and 3.2-, 2.2-and 1.7 times higher, respectively, than in controls (р < 0.001). Conclusion: High neopterin levels in the uveal tract tissues and anterior chamber aqueous fluid indicated its impact on the course of inflammation in animals with induced uveitis only and especially in those with induced both uveit...

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Modern Opportunities in Uveitis Treatment

Cited by 4 publications

References 35 publications

Detection of Torque Teno Virus in Intraocular Fluid in Inflammatory Diseases of the Choroid

Detection of Torque Teno Virus in Intraocular Fluid in Inflammatory Diseases of the Choroid

Effects of carnosine on the pro-antioxidative status of the anterior segment in experimental uveitis plus ocular hypertension

Neopterin level in the anterior segment of the eye in induced uveitis with ocular hypertension when treated by dipeptide carnosine

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