Modern Technologies for Synthesizing Drug Substances: Toward Highly Efficient Drug Production

Наркевич, И. А.; Tarasov, Igor N.; Голант, З. М.; Alekhin, A. V.

doi:10.1007/s11094-016-1366-5

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Continuous flow microreactors have been applied in the syntheses of highly value/low-throughput molecules − including, specifically, nitrated products. − The peculiarity of the small-diameter devices with embedded mixing and heat exchange, is the ability to enhance heat and mass transfer, allowing to precisely control temperature and concentration profiles. This allows to safely carry out reactions, adopting conditions under which a traditional batch reactor cannot operate .…”

Section: Introductionmentioning

confidence: 99%

Intensification of Nitrobenzaldehydes Synthesis from Benzyl Alcohol in a Microreactor

Russo

Somma

Marotta

et al. 2017

Org. Process Res. Dev.

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A one-step process to produce 2- and 3-nitrobenzaldehyde isomers starting from benzyl alcohol in aqueous mixed nitric and sulfuric acid was developed as an inherently safe continuous flow process in a microreactor. The previously published kinetic model was validated in a microreactor and used to optimize operating conditions in silico to attain the desired product distribution. The molar fractions of nitric and sulfuric acids were increased up to 0.35, 0.45, and temperature to 68 °C, which was impossible to do under batch conditions. Experiments under continuous flow conditions have shown that yields of about 42% and 96% for the ortho- and the meta- isomers, respectively, can be achieved

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