Thyroid gland (ThG) diseases lead at structure of the endocrine diseases. At the same time ThG-diseases frequency are age-associated and depend from influence of combination of negative external risk factors (Iodine deficiency, Selenium deficiency, technogenic stress rising, environmental pollution, high level of urbanization). Iodine prophylaxis is necessary at the all age groups and requires for pregnant woman. The legislative Iodine prophylaxis predetermines primarily the reduction of the frequency of occurrence of such ThG-diseases as diffuse euthyroid goiter and nodule goiter. The appearance and progression of diffuse euthyroid goiter are more typical for rural. The adequate (without overdosing) correction of Iodine deficiency is necessary in order to avoid the hypothyroidism, what is especially important for coastal urban and rural. It is noted the rising of the frequency of occurrence of autoimmune ThG-diseases and ThG antibodies carrying, including autoimmune polyendocrine syndromes. Selenium deficiency and Vitamin D deficiency must be adjusted along with Iodine deficiency. The natural and the technogenic strumogenes negatively effluenced to ThG are considered. It was proposed to consider the frequency of occurrence of ThG-cancer as the marker of ecological pollution. It was observed the connection of depression and ThG-function. The rural inhabitation affected to the severity of depression that is more actually for postmenopausal women. At the same time the correct formation of the urban landscape (in reorganization context) promotes the maintainance of ThG’s metabolic health.