Modification des réponses sensorielles corticales par stimulation de l'hippocampe dorsal chez le lapin

Cazard, P; Buser, P

doi:10.1016/0013-4694(63)90063-4

Cited by 33 publications

(4 citation statements)

References 19 publications

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“…Finally, Cazard and Buser (1963) found that attentive searching behavior was occasionally manifest a few seconds after the termination of non-epileptogenic stimulation in rabbits. Although the specifie behavioral descriptions vary, they aIl suggest that increases in general activity occur during the aftereffect of hippocampal stimulation.…”

Section: Discussionmentioning

confidence: 95%

Effect of hippocampal stimulation on feeding in the rat

Milgram¹

1969

Physiology & Behavior

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Section: Discussionmentioning

confidence: 95%

Effect of hippocampal stimulation on feeding in the rat

Milgram¹

1969

Physiology & Behavior

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“…Particularly striking was the change in the pattern of neuronal firing in relation to incoming afferent volleys in response to auditory stimulation. It is not hard to imagine how gross distortions in sensory or perceptual processes might occur even in minor temporal lobe seizures of amygdaloid or hippocampal origin (10,62) if similar changes can be demonstrated in the unitary activity of temporal neo-cortex, or in other cortical regions, during epileptic discharge of amygdaloid origin in man, studies of which we propose to do in the near future.…”

mentioning

confidence: 85%

Some Physiological Mechanisms involved in Epileptic Automatisms

Jasper

1964

Epilepsia

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SUMMARY Some basic physiological mechanisms which may be involved in epileptic disturbances of brain function have been reviewed with particular reference to temporal lobe automatisms (psychomotor or psychoparetic seizures). Microelectrode studies of the firing patterns of individual neurones, and changes in membrane potential in neurones whose activity has been recorded with intracellular microélectrodes has shown that inactivation by prolonged depolarization, and arrest of discharge by prolonged inhibition are as important as excitatory events in epileptic discharge. Profound alterations in the behaviour of single cells may occur without evidence of high‐voltage electrical activity in the usual EEG. Emphasis is placed upon changes in patterns of discharge in response to incoming sensory information which must cause important distortions in information processing by the brain, even during periods between gross overt clinical attacks. Amnesia and irrelevant automatic behaviour does not follow after‐discharge in amygdaloid and hippocampal structures in man unless epileptic activity spreads to affect brain stem structures, and unless there is significant change in neo‐cortical function. The “activation” pattern which characterizes the EEG over temporal and other cortical regions at the onset of such attacks is associated with striking changes in unitary activity in the temporal neo‐cortex of both hemispheres. It is concluded that it is the epileptic “activation paralysis” of limbic and brain stem circuits essential to the consolidation of memories in neo‐cortex which are necessarily involved in the typical temporal lobe automatism with amnesia. The importance of William Lennox's views on the neurochemical mechanisms involved in seizures is stressed, particularly in view of the growing evidence that chemical mechanisms are involved in the storage of memory, and certainly in excitatory and inhibitory processes of epileptic discharge. The rapid growth of knowledge in the field of genetically determined metabolic defects, as well as rapid technical advances in neurochemistry, should make it possible to advance our knowledge of the chemistry of seizures much more rapidly than it has been possible in the past. It was suggested that this might be an appropriate major concern of the American Epilepsy Society, as a tribute to William G. Lennox, its founder. RÉSUMÉ Des mécanismes basaux physiologiques pouvant être impliqués dans des troubles épileptiques de la fonction cérébrale ont été, en particulier, considered quant aux automatismes du lobe temporal (crises psychomotrices ou psychoparésiques). Des études microélectrodiques des “firing patterns” de neurones individuels et des changements du potentiel membraneux dans des neurones dont l'activité a été enregistrée avec des microélectrodes intracellulaires ont montré que l'inactivation par la dépolarisation prolongée, et arrêt de la décharge par l'inhibition prolongée sont aussi importants que des événements excitatoires dans la décharge épileptique. De profondes altérations...

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“…Beyond theta, optogenetic stimulation at lower (1 Hz; Chan et al, 2017 ) and higher (40 Hz; Weitz et al, 2015 ) rates in rat hippocampus influences BOLD activity in auditory cortex. Electrical stimulation at even faster rates in rabbits led to an increase in the amplitude of click responses in motor cortex ( Cazard and Buser, 1963 ), while other studies in cats found electrical stimulation of hippocampus leading to reduced auditory cortical responses to brief medial geniculate body electrical pulses ( Redding, 1967 ), and reduced click responses in cerebellum ( Fox et al, 1967 ) and hypothalamus ( Feldman and Dafny, 1968 ). Single-pulse electrical stimulation of hippocampus even in the absence of an auditory stimulus elicits rapid responses in the auditory cortex not only of cats ( Parmeggiani and Rapisarda, 1969 ) but also of humans.…”

Section: Anatomy and Auditory-hippocampal Pathwaysmentioning

confidence: 99%