Modification of Blood Redox Homeostasis by High-Intensity Interval Training

Costa, Karine Betriz; Magalhães, Silvia Mourão; Aguiar, Paula Fernandes de; Ottone, Vinícius de Oliveira; Tossige-Gomes, Rosalina; Magalhães, Flávio de Castro; Amorim, Fabiano T.; Rocha‐Vieira, Etel

doi:10.20455/ros.2018.805

Cited by 4 publications

(5 citation statements)

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“…These results are consistent with the ndings of some previous studies [33,38]. However, contrary to the ndings of the present study, Costa et al (2018) in blood erythrocytes showed that four weeks of HIIT signi cantly increased catalase activity and decreased thiobarbituric acid reactive substances (TBARS) [39]. Differences in subjects, duration of intervention (4 weeks vs. 8 weeks), intensity of exercise, and location of catalase activity (serum versus blood erythrocytes) may partly explain the differences in results.…”

Section: Discussionsupporting

confidence: 89%

High-intensity functional training modulates oxidative stress and improves physical performance in adolescent male soccer players: A randomized controlled trial

Niknam

Gaeini

Hamidvand

et al. 2023

Preprint

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Regular exercise training can decrease oxidative stress (OS) and up-regulate antioxidant functions in adult population. However, limited data exists considering OS responses in the pediatric population. The aim of this study was to investigate the effect of high-intensity functional training (HIFT) on the OS and performance in adolescent soccer players. In this randomized controlled trial, 20 adolescent soccer players (male, well-trained) were randomly divided into high intensity functional training (HIFT, n=10) and moderate intensity soccer technical training (MITT, n=10) groups. HIFT and MITT was performed for 8 weeks (3 days/week). Baseline OS biomarkers (MDA, 8-OHDG, H2O2, GPx and CAT) and physical performance (VO2peak, vertical jump height (VJH) and maximal explosive power (MEP)) were assessed before and after the intervention. Repeated measure mixed ANOVA (2×2) with a significance level of P<0.05 was used to determine differences between and within subjects. The main effect of interaction was significant for VO2peak, VJH and MEP (P<0.05). The main effect of interaction was not significant for CAT, 8-OHDG, GPx, H2O2 and MDA (P>0.05). Following intervention, VO2peak and VJH performance in the HIFT were significantly higher than MITT (P<0.05). MDA and H2O2 in the HIFT decreased significantly (P<0.05), but no significant changes were observed in the MITT (P>0.05). CAT activity decreased significantly (P<0.05), while GPx activity increased significantly (P<0.05) in both groups. 8-OHDG did not show significant changes in both groups (P>0.05). 8 weeks of HIFT did not cause greater OS compared to MITT, while could improve physical performance parameters. Trial registration: The present study was a randomized controlled trial (registration number: IRCT20190530043762N1, 25/09/2019, Iran)

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Section: Discussionsupporting

confidence: 89%

High-intensity functional training modulates oxidative stress and improves physical performance in adolescent male soccer players: A randomized controlled trial

Niknam

Gaeini

Hamidvand

et al. 2023

Preprint

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“…However, Davison [17] did not evaluate neutrophil redox status. We and others have previously shown that a single HIIE session alters blood redox status [7,16,17,24]. We have also demonstrated that HIIE acutely disrupts lymphocyte proliferation and redox status [59], which supports the hypothesis that modification of cellular redox status contributes to the effects of exercise on immune cell function.…”

Section: Discussionsupporting

confidence: 81%

“…Thus, during HIIE sessions, neutrophils are exposed to great metabolic, endocrine and inflammatory demands compared to prolonged and continuous exercise, but only for a short period of time. Studies suggest that HIIE alters immune cell redox status and function as much as prolonged continuous exercise [16,17,59]. However, the duration of these changes is unknown.…”

Section: Introductionmentioning

confidence: 99%

Late Neutrophil Priming Following a Single Session of High-intensity Interval Exercise

et al. 2019

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This study evaluated the effect of an acute high-intensity interval exercise (HIIE) session on the function of human neutrophils. Twelve sedentary men performed a HIIE session (8 bouts of 60 s at 90% of peak power, intercalated with 75 s of active recovery at 30 W). Neutrophils were collected before, 30 min and 24 h after the exercise session for the evaluation of phagocytic capacity, expression of phagocytic receptors, reactive oxygen species generation, and redox status. 24 h after the HIIE session, an increase was observed in both neutrophil phagocytic capacity and yeast-induced generation of reactive oxygen species, which indicates neutrophil priming in response to an acute HIIE session. Neutrophils also presented an increase in superoxide dismutase activity 24 h after the exercise. Improvement in neutrophil function was accompanied by increased serum levels of IL-8 and increased concentration of plasma lactate dehydrogenase. Our findings show a late activating effect of one HIIE session on neutrophils. We propose that priming of neutrophils by HIIE may play a role in skeletal muscle inflammation after exercise.

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“…The change in redox homeostasis is induced by physiological and non-physiological stimuli such as acute aerobic and anaerobic exercise training [9]. ROS production is accepted by mitochondria, and the ETC is one of the major sites for the production of free radicals.…”

Section: Discussionmentioning

confidence: 99%

“…HIIT has been shown to increase mitochondrial enzyme activity and increase muscle oxidative capacity compared to conventional endurance training methods [7,8]. The change in redox homeostasis is induced by physiological and non-physiological stimuli such as acute aerobic and anaerobic exercise [9]. Ashton et al showed that maximal exercise tripled the concentration of serum free radicals and also increased the amount of malondialdehyde (MDA), which is an indicator of lipid peroxidation [10].…”

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confidence: 99%

Expression of antioxidant enzymes genes in the liver and cardiac tissues of rats under L-carnitine administration and high-intensity

Shahouzehi¹,

Masoumi‐Ardakani²,

Aminizadeh³

et al. 2021

Ukr.Biochem.J

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reactive oxygen and nitrogen species are produced in the body both in normal and pathological processes and can alter cell redox and affect cell functions. Exercise training is able to modulate oxidant/ antioxidants balance. In this study, we aimed to evaluate expression of antioxidant enzymes genes in the liver and cardiac tissues of rats that performed high-intensity interval training (hIIT) and received L-carnitine (LCar). Thirty-two male Wistar rats were were randomly assigned into 4 groups (n = 8) as follows: 1. Untreated control; 2. The group that received LCAR (200 mg/kg/day i.p.); 3. The group that performed HIIT on a readmill (5 days/week for 4 weeks); 4. The group that received LCAR and performed HIIT. At the end of the study, liver and cardiac tissues were excised and used to quantify glutathione peroxidase (GPX), superoxide dismutase (SOD), catalase (CAT) and NF-κB genes expression by real-time PCR. It was found that both in LCAR and HIIT groups GPX, SOD and NF-κB (P < 0.01) expression in cardiac and liver tissues was significantly increased compared to the indices in the control group. In LCAR-HIIT group SOD and NF-κB expression in the liver was significantly increased compared to the group that received LCAR only (P = 0.046). our results showed that LCar supplementation is useful to improve oxidative status in cardiac and liver tissues of rat during exercise training.

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Modification of Blood Redox Homeostasis by High-Intensity Interval Training

Cited by 4 publications

References 0 publications

High-intensity functional training modulates oxidative stress and improves physical performance in adolescent male soccer players: A randomized controlled trial

High-intensity functional training modulates oxidative stress and improves physical performance in adolescent male soccer players: A randomized controlled trial

Late Neutrophil Priming Following a Single Session of High-intensity Interval Exercise

Expression of antioxidant enzymes genes in the liver and cardiac tissues of rats under L-carnitine administration and high-intensity

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