Modification of Dietary Habits (Mediterranean Diet) and Cancer Mortality in a Southern Italian Village from 1960 to 1996

Lorenzo, Antonino De; Andréoli, A.; Sorge, Roberto; Iacopino, L; Montagna, S.; Promenzio, L.; Serrano, Pepe

doi:10.1111/j.1749-6632.1999.tb08738.x

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…This has eventually led to a marked increase in the consumption of milk and dairy products, meat, and animal fat, and to a corresponding decrease in the intake of cereals and unrefined carbohydrates. This significant change has been proposed as potentially responsible for an increased risk of developing coronary heart disease or cancer, regardless of other factors (31,32).…”

Section: Discussionmentioning

confidence: 99%

A Traditional Mediterranean Diet Decreases Endogenous Estrogens in Healthy Postmenopausal Women

Carruba¹,

Granata²,

Pala³

et al. 2006

Nutrition and Cancer

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Breast cancer incidence and mortality rates are markedly lower in the south than in the north of Europe. This has been ascribed to differences in lifestyle and, notably, dietary habits across European countries. However, little information exists on the influence of different dietary regimens on estrogens and, hence, on breast cancer risk. Here we report results of our MeDiet Project, a randomized, dietary intervention study aimed to assess the effect of a Mediterranean diet on the profiles of endogenous estrogens in healthy postmenopausal women. Out of the 230 women who initially volunteered to participate in the study, 115 were found to be eligible and were enrolled. Women were then randomly assigned into an intervention (n = 58) and a control (n = 57) group. Women in the intervention group adhered to a traditional, restricted Mediterranean diet for 6 mo, whereas women in the control group continued to follow their regular diet. Women in the intervention group changed their dietary regimen substantially, and this eventually led to a shift from a prevalent intake of animal fat and proteins to a prevalent intake of vegetable fat and proteins. Regarding urinary estrogens, no significant difference was observed between the intervention and control groups at baseline. After 6 mo, however, control women did not show any major change but women in the intervention group exhibited a significant decrease (over 40%) of total estrogen levels (P < 0.02). The largest part of this modification was based on a marked decrease of specific estrogen metabolites, including hydroxy- and keto-derivatives of estradiol or estrone. To our knowledge, this is the first report to show that a traditional Mediterranean diet significantly reduces endogenous estrogen. This may eventually lead to identify selected dietary components that more effectively decrease estrogens levels and, hence, provide a basis to develop dietary preventive measures for breast cancer.

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Section: Discussionmentioning

confidence: 99%

A Traditional Mediterranean Diet Decreases Endogenous Estrogens in Healthy Postmenopausal Women

Carruba¹,

Granata²,

Pala³

et al. 2006

Nutrition and Cancer

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“…Progressive loss of traditional dietary habits and increased consumption of animal source and high-glycemic index foods led to an average decrease in MAI from 9.4 to 2.8 in males and from 11.4 to 2.5 in females over that period, in conjunction with a progressively increasing cancer incidence [25].…”

Section: Discussionmentioning

confidence: 99%

Body composition changes and cardiometabolic benefits of a balanced Italian Mediterranean Diet in obese patients with metabolic syndrome

et al. 2012

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Metabolic syndrome (MS) is a cluster of metabolic alteration associated with a higher risk of cardiovascular disease and overall mortality than the single alterations alone. The Italian Mediterranean Diet (IMD) can exert a positive effect on cardiovascular risk and related morbidity and mortality. The aim was to evaluate the benefits of dietary intervention based on a typical IMD on body composition, cardiometabolic changes and reduction in cardiovascular disease in patients with MS. Eighty White Italian subjects with MS were prescribed a balanced hypocaloric IMD. We investigated dietary habits and impact of the diet on health status, blood biochemical markers, anthropometric measurements and body composition during a 6-month follow-up period. Body composition, fat mass and distribution were assessed by Dual X-ray absorptiometry. Adherence to the IMD led to a decrease in body weight (102.59 ± 16.82 to 92.39 ± 15.94 kg, p < 0.001), body mass index (BMI) (38.57 ± 6.94 to 35.10 ± 6.76, <0.001) and waist circumference (112.23 ± 12.55 vs 92.42 ± 18.17 cm, p < 0.001). A significant loss of total body fat especially in waist region was observed. The MS was resolved in 52 % of the patients. Significant improvements in systolic and diastolic blood pressure and fasting glucose occurred. Low-density lipoprotein cholesterol was reduced from 128.74 ± 33.18 to 108.76 ± 38.61 mg/dl (p < 0.001), triglycerides from 169.81 ± 80.80 to 131.02 ± 63.88 mg/dl (p < 0.001). The present results suggest that a dietary intervention based on a typical IMD effectively promotes weight loss and reduces the growing burden of cardiovascular risk factors that typifies patients with MS

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“…Sleep disorders can cause excessive activation of the sympathetic nervous system, leading to elevated cortisol levels, elevated glucose and blood pressure, reduced heart rate variability, and elevated levels of inflammatory markers [ 43 ]. Thus, there was a broad impact of sleep disorders on disease development and prognosis, such as cardiovascular and cerebrovascular events, cognitive decline, and cancer occurrence [ 16 , 20 , 44 ]. With NHANES data representing different ethnic groups across the United States, our study preliminarily verified that both sleep disorders and poor adherence to the MED significantly increased the risk of all-cause mortality and cardiovascular mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The MED also has anti-cancer effects. Several studies have found that the MED reduces the risk of certain types of cancer, including breast, colorectal, stomach, and prostate cancers [ 8 , 9 ] This may be due to that MED is rich in antioxidants and other beneficial components that help protect cells from free radical damage, which in turn reduces the formation and growth of cancer cells [ 10 , 11 ] The MED has been shown to reduce the risk of cardiovascular mortality, cancer mortality, and all-cause mortality [ 12 – 16 ]. Relevant evidence suggests that the beneficial effects of MED may be associated with its ability to lower inflammation levels, oxidative stress levels, and improve metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study

et al. 2023

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Background There is a bidirectional effect between sleep disorders and Mediterranean diet (MED), but the joint effect of MED and sleep disorders on mortality is unclear. The aim of this study was to investigate whether there is a synergistic effect of adherence to MED and sleep disorders on all-cause and cause-specific mortality. Methods The study included 23,212 individuals in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2014. A 9-point evaluation score, alternative Mediterranean diet (aMED) index was used to assess adherence to MED. Sleep disorder and hours of sleep were assessed by structured questionnaires. Cox regression models were used to assess the relationship between sleep disorders, aMED and all-cause mortality, cause-specific mortality (cardiovascular-related death, cancer-related death). The interaction effect of sleep disorders with aMED on mortality was further assessed. Results Results showed that participants with lower aMED and presence of sleep disorders had significantly higher risk of all-cause mortality and cardiovascular-related mortality (HR, 2.16, 95% CI, 1.49–3.13, P < 0.0001; HR, 2.68, 95% CI, 1.58–4.54, P = 0.0003). A significant interaction effect was found between aMED and sleep disorders on cardiovascular mortality (p for interaction = 0.033). No significant interaction existed between aMED and sleep disorders on all-cause mortality (p for interaction = 0.184) and cancer-related mortality (p for interaction = 0.955). Conclusions Poorer adherence to MED and sleep disorders synergistically increased long-term all-cause mortality and cardiovascular mortality in NHANES population.

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Modification of Dietary Habits (Mediterranean Diet) and Cancer Mortality in a Southern Italian Village from 1960 to 1996

Cited by 8 publications

References 12 publications

A Traditional Mediterranean Diet Decreases Endogenous Estrogens in Healthy Postmenopausal Women

A Traditional Mediterranean Diet Decreases Endogenous Estrogens in Healthy Postmenopausal Women

Body composition changes and cardiometabolic benefits of a balanced Italian Mediterranean Diet in obese patients with metabolic syndrome

Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study

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