Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

Zimmer, Luc; Delion-Vancassel, Sylvie; Durand, Georges; Guilloteau, Denis; Bodard, Sylvie; Besnard, Jean‐Claude; Chalon, Sylvie

doi:10.1016/s0022-2275(20)32071-x

Cited by 184 publications

(12 citation statements)

References 40 publications

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“…The decrease in ventral striatal DA corresponds well with previous results showing that amphetamine and tyramine have reduced DA-releasing capability in the nucleus accumbens of n-3-def rats (Zimmer et al, 2000(Zimmer et al, , 2002. The blunted effects of amphetamine and tyramine are probably related to reductions in the number of vesicular monoamine transporters in deficient rats, which lead to depletion of vesicular DA available for release (Chalon, 2006;Zimmer et al, 2000Zimmer et al, , 2002. However, Zimmer et al (2000) reported a paradoxical elevation of basal DA levels in microdialysis samples collected from the nucleus accumbens shell of awake n-3-def rats.…”

Section: Discussionsupporting

confidence: 91%

An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze.

Федорова

Hussein

Baumann

et al. 2009

Behavioral Neuroscience

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In this study, the authors demonstrate that rats with n-3 fatty acid deficiency display spatial learning deficits in the Barnes circular maze. Dams were deprived of n-3 fatty acids during pregnancy and lactation, and their offspring were weaned to the same deficient diet. There was a 58% loss of brain docosahexaenoic acid (DHA) in the n-3 fatty acid-deficient rats in comparison to n-3 fatty acid-adequate rats. At 8 weeks of age, deficient rats demonstrated moderate impairment in Barnes maze performance compared with the n-3 fatty acid-adequate rats during the initial training. In the reversal learning task, the n-3 fatty acid-deficient rats showed a profound deficit in performance: They required more time to find a new position of the escape tunnel, which was accompanied by a higher number of errors and perseverations. The n-3 fatty acid-deficient rats had reduced tissue levels of dopamine in the ventral striatum and enhanced levels of the metabolite 3,4-dihydroxyphenylacetic acid in frontal cortex and hypothalamus. In summary, this study demonstrates that rats with low brain DHA have a deficit in spatial reversal learning that could be related to changes in dopamine transmission in critical brain circuits.

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Section: Discussionsupporting

confidence: 91%

An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze.

Федорова

Hussein

Baumann

et al. 2009

Behavioral Neuroscience

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“…Thus, the FFAs-FFAR1 system was suggested to play an important role in striatal DA and 5-HT effluxes. In fact, previous studies using animals deficient in n-3 polyunsaturated FFAs reported that the deficiency enhanced anxiety-like behaviors in mice ( Harauma and Moriguchi, 2011 ) and modified striatal DA availability or basal DA release in rats ( Zimmer et al, 2000 ; Bondi et al, 2014 ), which may be at least partly consistent with both our previous ( Aizawa et al, 2019 ) and present data. Conversely, n-3 FFAs, such as eicosapentaenoic acid and docosahexaenoic acid, were suggested to reduce stress and anxiety-like behaviors in animal studies ( Song et al, 2007 ; Aizawa et al, 2019 ), and supplementation of n-3 FFAs reduced the risk of progression to psychotic disorder and psychiatric morbidity ( Amminger et al, 2015 ).…”

Section: Discussionsupporting

confidence: 93%

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice

et al. 2021

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The free fatty acid receptor 1 (FFAR1) is suggested to function as a G protein-coupled receptor (GPR40) for medium-to-long-chain free fatty acids. Previous studies on the expression of FFAR1 revealed that the nigrostriatal region is one of the areas which express abundant FFAR1 mRNA/protein in the central nervous system (CNS). However, the role of FFAR1 in the CNS has been still largely unclarified. Here, we examined a possible functional role of FFAR1 in the control of extracellular concentrations of striatal monoamines and cocaine-induced locomotor activity. Microdialysis analysis revealed that the basal level of extracellular dopamine (DA) was significantly elevated, while the basal serotonin (5-HT) level tended to be reduced in the striatum of FFAR1 knockout (−/−) mice. Interestingly, local application of a FFAR1 agonist, GW9508, markedly augmented the striatal 5-HT release in FFAR1 wild-type (+/+) mice, whereas topical application of a FFAR1 antagonist, GW1100, significantly reduced the 5-HT release. However, the enhanced 5-HT release was completely lost in −/− mice. Although acute administration of cocaine enhanced the locomotor activity in both +/+ and −/− mice, the magnitude of the enhancement was significantly reduced in −/− mice. In addition, intraperitoneal injection of GW1100 significantly decreased the cocaine-induced locomotor enhancement. These results suggest that FFAR1 has a facilitatory role in striatal 5-HT release, and the evoked 5-HT release might contribute to enhance cocaine-induced locomotor activity.

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“…EFAs have been shown to influence the regulation of metabolism of dopamine. In rats having the diet poor in fatty acids ω-3, the increase in the concentration of dopamine and decrease in the concentration of its metabolites in the nucleus accumbens was observed, compared with the diet with optimal fatty acid content [62]. In turn, in the frontal cortex, the decrease in concentration was observed.…”

Section: The Role Of Efas In the Functioning Of Cnsmentioning

confidence: 90%

“…U szczurów karmionych dietą deficytową w kwasy ω-3 obserwowano wzrost stężenia dopaminy oraz spadek stężenia jej metabolitów w jądrze półleżącym w porównaniu z dietą o optymalnej zawartości kwasów tłuszczowych [62]. W korze czołowej obserwowano z kolei spadek stężenia.…”

Section: Rola Nnkt W Funkcjonowaniu Oununclassified

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Róg

Karakuła-Juchnowicz

2016

Current Problems of Psychiatry

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Despite the increasing offer of antipsychotic drugs, the effectiveness of pharmacotherapy in schizophrenia is still unsatisfactory. Drug resistance, lack of complete remission and the increasing risk of metabolic complications are the reasons why the new forms of therapy in schizophrenia among which unsaturated essential fatty acids omega 3 (EFAs ω-3) affecting the proper functioning of nervous system, are mentioned, are being looked for.Fatty acids represent 50-60% of the dry weight of the brain and diet is one of the factors that influence the value of each of the fat fractions in the neuron membranes. Patients with schizophrenia tend to have irregular nutritional status concerning essential fatty acids ω-3, which might result from metabolic disorders or irregular consumption of fatty acids.Apart from being a review of the literature on this subject, this very paper characterizes essential fatty acids ω-3, their metabolism, the most important sources in the diet and the opinions of experts in the field about the recommended intake. It pays attention to the role of essential fatty acids in both the structure and functioning of the central nervous system is, as well as their role in the pathophysiology of schizophrenia, with particular emphasis on the membrane concept by David Horrobin. The assessment of the errors in consumption and metabolism of essential fatty acids are described as well.The evidence was found both in epidemiological and modeling studies. It supports the participation of EFAs in etiopathogenesis and pathophysiology of schizophrenia. Further research is needed, both observational and interventional, as to the role of essential fatty acids ω-3 in the functioning of the CNS as well as the development and course of schizophrenia.

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Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

Cited by 184 publications

References 40 publications

An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze.

An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze.

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

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