1978
DOI: 10.1111/j.1432-1033.1978.tb12560.x
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Modification of Elongation‐Factor‐Tu · Guanine‐Nucleotide Interaction by Kirromycin

Abstract: Kirromycin activates functions of elongation factor Tu (EF-Tu) that normally require the presence of specific effectors [Wolf et al. (1974) Proc. Nut1 Acud. Sci. U.S.A. 71, 4910-49141. As a result, the EF-Tu GTPase activity is uncoupled from aminoacyl-tRNA and ribosomes. For a better understanding of the action of the antibiotic, we have studied its effect on the interaction between EF-Tu and guanine nucleotides and compared this with the action of the physiological effectors aminoacyltRNA and elongation facto… Show more

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Cited by 109 publications
(118 citation statements)
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“…Nucleotide-free EF-Tu was prepared as in [12]. The specific activities of [7-32p]GTP and [3H]GDP were determined by isotopic dilution.…”
Section: Methodsmentioning
confidence: 99%
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“…Nucleotide-free EF-Tu was prepared as in [12]. The specific activities of [7-32p]GTP and [3H]GDP were determined by isotopic dilution.…”
Section: Methodsmentioning
confidence: 99%
“…Dissociation rate constants, association rate constants and GTPase activity were determined as in [12]. Details are in the legends to tables and figures.…”
Section: Methodsmentioning
confidence: 99%
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