Modification of Innervation Pattern by Fluoroquinolone Treatment in the Rat Salivary Glands

Abstract

Fluoroquinolone antibiotics (FQAs) are widely used in dental and medical therapy. Despite their known severe adverse actions on the central and peripheral nervous system, little attention has been directed toward the potential toxic side effects of these compounds on the oral tissues. As the saliva secretion is controlled by the nervous system and neuropeptides, the neurotoxic effect of pefloxacin (PEF), a representative member of FQAs, was studied in rats in the present work. Previously, we demonstrated a significant weight loss of parotid gland tissue, a marked decrease in 3H-thymidine incorporation, a decreased volume of saliva and amylase activity of the glandular tissue in response to PEF. Animals received intraperitoneal injection of PEF (20 mg/100 g body weight daily) for 3 and 7 days. Normal histology, and neurofilament 200, substance P (SP) and calcitonin gene-related polypeptide (CGRP) containing nerve fibers were detected with immunohistochemical methods. A marked decrease of the weights in salivary glands and the acinar diameters were measured. Similarly, a strong and significant decrease of the number of SP and CGRP containing nerve fibers were detected. These findings suggest that the impaired morphology and innervation pattern of salivary glands is related to the neurotoxic adverse effect of FQA treatment. Anat Rec,

Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

“…The fundamental cellular and molecular mechanisms underlying the loss of salivary gland function are not clearly understood (4). Evidence derived largely from animal models supports the notion that radiation-induced salivary hypofunction is a multifactorial process initiated by DNA damage to various tissue components within the gland, including the parenchymal acinar cells, endothelium, stem/progenitor cells and also parasympathetic innervation (10)(11)(12)(13)(14)(15)(16). Apoptosis, occurring within the first few days following irradiation, has also been proposed as a fundamental mechanism underlying loss of both acinar cells and glandular innervation (15,17,18).…”

Investigation of the Effect of GnRH (Deslorelin) on the Histochemical Structure of Salivary Glands in Rats

“…In a study conducted by Kelentey et al (2010), of the salivary glands of fluoroquinolone-treated rats, it was reported that the diameter, size, and histological structure of sublingual and submandibular glands changed. Salivary ducts and salivary gland paranchyma in experimental groups, innervation weakened.…”