Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Alswieleh, Abdullah M.

doi:10.1155/2020/9176257

Cited by 18 publications

(10 citation statements)

References 43 publications

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“…As the release of gallic acid is complete within 1 h for MCM-41 in SIF and MCM-48 in SGF, but also as the release of the GA from the other two systems is fast, two optimization approaches may be considered. First, the surface of the mesoporous materials could be functionalized with different functional groups or, second, they could be embedded into bioactive polymers for a further tuning of the GA release [ 55 , 56 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

et al. 2022

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This paper aimed to develop two types of support materials with a mesoporous structure of mobile crystalline matter (known in the literature as MCM, namely MCM-41 and MCM-48) and to load them with gallic acid. Soft templating methodology was chosen for the preparation of the mesoporous structures—the cylindrical micelles with certain structural characteristics being formed due to the hydrophilic and hydrophobic intermolecular forces which occur between the molecules of the surfactants (cetyltrimethylammonium bromide—CTAB) when a minimal micellar ionic concentration is reached. These mesoporous supports were loaded with gallic acid using three different types of MCM—gallic acid ratios (1:0.41; 1:0.82 and 1:1.21)—and their characterizations by FTIR, SEM, XRD, BET and drug release were performed. It is worth mentioning that the loading was carried out using a vacuum-assisted methodology: the mesoporous materials are firstly kept under vacuum at ~0.1 barr for 30 min followed by the addition of the polyphenol solutions. The concentration of the solutions was adapted such that the final volume covered the wet mesoporous support and—in this case—upon reaching normal atmospheric pressure, the solution was pushed inside the pores, and thus the polyphenols were mainly loaded inside the pores. Based on the SBET data, it can be seen that the specific surface area decreased considerably with the increasing ratio of gallic acid; the specific surface area decreased 3.07 and 4.25 times for MCM-41 and MCM-48, respectively. The sample with the highest polyphenol content was further evaluated from a biological point of view, alone or in association with amoxicillin administration. As expected, the MCM-41 and MCM-48 were not protective against infections—but, due to the loading of the gallic acid, a potentiated inhibition was recorded for the tested gram-negative bacterial strains. Moreover, it is important to mention that these systems can be efficient solutions for the recovery of the gut microbiota after exposure to antibiotics, for instance.

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Section: Resultsmentioning

confidence: 99%

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

et al. 2022

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“…Two strong bands appear at 1016 cm − 1 and 1136 cm − 1 corresponding to the Si-O-Si asymmetric stretching vibrations [ 33 ]. Furthermore, the symmetric stretching and the bending mode vibrations of Si-O-Si appear at 738 cm − 1 [ 39 ] and 405 cm − 1 , respectively. Upon addition of phosphate to form Si-P, these peaks have a shift (405→467, 738→800, 1016→1066, 1136→1226, 1597→1646, and 3401→3465) [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

A Novel P@SiO2 Nano-Composite as Effective Adsorbent to Remove Methylene Blue Dye from Aqueous Media

et al. 2023

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This work aims to prepare a novel phosphate-embedded silica nanoparticles (P@SiO2) nanocomposite as an effective adsorbent through a hydrothermal route. Firstly, a mixed solution of sodium silicate and sodium phosphate was passed through a strong acidic resin to convert it into hydrogen form. After that, the resultant solution was hydrothermally treated to yield P@SiO2 nanocomposite. Using kinetic studies, methylene blue (MB) dye was selected to study the removal behavior of the P@SiO2 nanocomposite. The obtained composite was characterized using several advanced techniques. The experimental results showed rapid kinetic adsorption where the equilibrium was reached within 100 s, and the pseudo-second-order fitted well with experimental data. Moreover, according to Langmuir, one gram of P@SiO2 nanocomposite can remove 76.92 mg of the methylene blue dye. The thermodynamic studies showed that the adsorption process was spontaneous, exothermic, and ordered at the solid/solution interface. Finally, the results indicated that the presence of NaCl did not impact the adsorption behavior of MB dye. Due to the significant efficiency and promising properties of the prepared P@SiO2 nanocomposite, it could be used as an effective adsorbent material to remove various cationic forms of pollutants from aqueous solutions in future works.

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“…However, glutaraldehyde can potentially be cytotoxic [ 26 ]. To improve the properties of silica, its surface can be modified by the covalent attachment of several functional groups, e.g., amine, thiol, and sulfonic groups [ 27 ]. In particular, tertiary amines have been evaluated as material’s surface modifier.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Enzyme Reuse through the Bioconjugation of L-Asparaginase and Silica-Based Supported Ionic Liquid-like Phase Materials

et al. 2022

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L-asparaginase (ASNase) is an amidohydrolase that can be used as a biopharmaceutical, as an agent for acrylamide reduction, and as an active molecule for L-asparagine detection. However, its free form displays some limitations, such as the enzyme’s single use and low stability. Hence, immobilization is one of the most effective tools for enzyme recovery and reuse. Silica is a promising material due to its low-cost, biological compatibility, and tunable physicochemical characteristics if properly functionalized. Ionic liquids (ILs) are designer compounds that allow the tailoring of their physicochemical properties for a given task. If properly designed, bioconjugates combine the features of the selected ILs with those of the support used, enabling the simple recovery and reuse of the enzyme. In this work, silica-based supported ionic liquid-like phase (SSILLP) materials with quaternary ammoniums and chloride as the counterion were studied as novel supports for ASNase immobilization since it has been reported that ammonium ILs have beneficial effects on enzyme stability. SSILLP materials were characterized by elemental analysis and zeta potential. The immobilization process was studied and the pH effect, enzyme/support ratio, and contact time were optimized regarding the ASNase enzymatic activity. ASNase–SSILLP bioconjugates were characterized by ATR-FTIR. The bioconjugates displayed promising potential since [Si][N3444]Cl, [Si][N3666]Cl, and [Si][N3888]Cl recovered more than 92% of the initial ASNase activity under the optimized immobilization conditions (pH 8, 6 × 10−3 mg of ASNase per mg of SSILLP material, and 60 min). The ASNase–SSILLP bioconjugates showed more enhanced enzyme reuse than reported for other materials and immobilization methods, allowing five cycles of reaction while keeping more than 75% of the initial immobilized ASNase activity. According to molecular docking studies, the main interactions established between ASNase and SSILLP materials correspond to hydrophobic interactions. Overall, it is here demonstrated that SSILLP materials are efficient supports for ASNase, paving the way for their use in the pharmaceutical and food industries.

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Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Cited by 18 publications

References 43 publications

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential

A Novel P@SiO2 Nano-Composite as Effective Adsorbent to Remove Methylene Blue Dye from Aqueous Media

Enhanced Enzyme Reuse through the Bioconjugation of L-Asparaginase and Silica-Based Supported Ionic Liquid-like Phase Materials

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