Modification of mitogen-driven lymphoproliferation by ceftriaxone in normal and immunocompromised mice

Jiménez-Valera, Marı́a; Moreno, Eva María Olmedo; Amat, Maria Angeles; Ruiz‐Bravo, Alfonso

doi:10.1016/j.ijantimicag.2003.04.001

Cited by 9 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cyclophosphamide was used to establish an experimental model for immunocompromised mice. This myelotoxic agent has been frequently used to induce neutropenia in laboratory animals to make them susceptible hosts for experimental infections with different pathogens (Jimenez‐Valera et al , 2003). In the present case, the treatment resulted in a significant decrease in the leukocyte counts in peripheral blood samples, clearly indicating a compromised situation of the immune system, not prevented by the probiotic L. plantarum strain.…”

Section: Discussionmentioning

confidence: 99%

“…To determine the immunomodulatory effect of the probiotic bacterium, PBL counts were performed on the last day of the trial. For this purpose, blood samples were obtained by a retro‐orbital puncture with heparinized capillary tubes in ether‐anesthetized mice, and counts were performed in a hemocytometer as described previously (Jimenez‐Valera et al , 2003). Differences were checked for statistical significance ( P <0.05) using Student's t ‐test.…”

Section: Methodsmentioning

confidence: 99%

“…The aim of this study was to evaluate the effect of a bacterium isolated from a commercially available dairy product (Bujalance et al , 2006) and characterized as Lactobacillus plantarum , on both the host immune system and the gut microbiota. For this purpose, a mouse model previously validated for the study of immunemodulating compounds under different immunological conditions was used (Jimenez‐Valera et al , 2003). The Lactobacillus strain fulfilled all the in vitro requirements described to consider potentially probiotic bacteria (Bujalance et al , 2007).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A strain of Lactobacillus plantarum affects segmented filamentous bacteria in the intestine of immunosuppressed mice

Egert

Jiménez-Valera

Monteoliva‐Sánchez

et al. 2008

FEMS Microbiology Ecology

Self Cite

View full text Add to dashboard Cite

Segmented filamentous bacteria (SFB) are present in the gastrointestinal tract of mice from weaning until the maturation of the immune system. Probiotic bacteria also have an effect on host immunity. To study the relationships established between these bacteria, samples from a mouse model fed with Lactobacillus plantarum under different immunological conditions were analysed. SFB populations were measured by a newly designed group-specific quantitative PCR assay. The results confirmed the presence of the probiotic in the intestine and an expansion of SFB in the ileum of immunocompromised mice, which was abolished upon administration of L. plantarum, an effect not described to date.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A strain of Lactobacillus plantarum affects segmented filamentous bacteria in the intestine of immunosuppressed mice

Egert

Jiménez-Valera

Monteoliva‐Sánchez

et al. 2008

FEMS Microbiology Ecology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Blood samples were obtained by heart puncture with disposable syringes in ether‐anesthetized chickens. The number of PBL in the blood was enumerated using a hemocytometer (Housser, Horsham, PA), as described previously (Jimenez‐Valera et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Colonization and distribution of segmented filamentous bacteria (SFB) in chicken gastrointestinal tract and their relationship with host immunity

Liao

Yin

Sun

et al. 2012

FEMS Microbiol Ecol

View full text Add to dashboard Cite

Uncultivable segmented filamentous bacteria (SFB) reside in the gastrointestinal (GI) tract of mammals and can boost the host immunity. Immunoglobulin A (IgA) from mother's milk has been previously shown to be a key factor in regulating SFB colonization. Because neonatal chicken cannot acquire IgA from maternal milk, they are a good model to examine the role of IgA in SFB colonization. Here, we used the fluorescent in situ hybridization (FISH) and quantitative PCR (qPCR) to monitor the colonization and distribution of SFB in chickens aged from 2‐day‐old to 6‐week‐old. Early SFB colonization, which primarily occurred in the ileal mucosa (< 13 days old), was IgA independent. From the age of 17–42 days, there was an increase in IgA in the gut mucosa, which was correlated with a decrease in SFB. To examine the effect of probiotics and immunosuppression on SFB colonization, we treated the chickens by feeding them Lactobacillus delbrueckii or giving them a subcutaneous injection of cyclophosphamide (CTX). Feeding lactobacilli at birth rendered SFB colonization occurring 4 days earlier, while CTX treatment increases the SFB colonization through reducing the other non‐SFB bacteria. Altogether, our data suggest that early colonization of SFB in chicken occurs independently of IgA and the population of SFB in the GI tract of chicken may be manipulated from birth via probiotic or CTX treatment.

show abstract

“…Initial studies showed no effect of ceftriaxone on in vitro phagocyte T cell function, or cytokine production (Gialdroni et al 1984;Pacheco et al 1994;Meloni et al 1995) and no change in neutrophil or phagocyte function, peripheral WBC, serum immunoglobulins, or lymphocyte subpopulation in humans (Gialdroni et al 1984;Karakaya et al 1995). However, recent studies indicate significant immunomodulatory effects of ceftriaxone, including in vitro increase in phagocyte and T cell chemotaxis, attenuation of cyclophosphamide induced suppression of lymphoproliferation, protection of neurons against apoptotic death induced by ionizing radiation, and reduced levels of pro-inflammatory cytokines IFN-gamma, TNF-alpha, matrix metallo-proteinase (MMP)-9, activated caspase-9, IL-17, decreased antigen presentation to and reduced migration of T cells (Gialdroni et al 1984;Jimenez-Valera et al 2003;Tikka 2001;Brooks et al 2005;Chu et al 2007;Melzer et al 2008). …”

Section: Discussionmentioning

confidence: 99%

Ceftriaxone and Infection in First Episode Adolescent Psychosis

Mehmet

PatelSanjay

Aurora

et al. 2013

Journal of Child and Adolescent Psychopharmacology

View full text Add to dashboard Cite

Chief Complaint and Presenting ProblemJ . is a 16-year-old adolescent boy in tenth grade referred to adolescent inpatient service after several months of progressive withdrawal that culminated in marked decrease in speech and activity, and refusal to leave his room. J. was referred from home to a local emergency department by mobile crisis services, and then transferred to an adolescent inpatient unit for admission. History of Present IllnessMother reported an uneventful history, denying recent or past psychiatric symptoms for psychotic, mood, developmental, disruptive behavior, impulse control, and anxiety disorders. Two years prior to admission, at age 14, J. was reported to have been shot in the lower extremity by a stray bullet; this injury resulted in a slow, unsteady, limping gait and chronic foot infection. As a result, J. was absent from school much of the year. Although he went out with his friends occasionally, he was reportedly not as active as he had been in the past. Neither J. nor his mother endorsed mood or posttraumatic anxiety symptoms for that time period. However, J. reported that he could not play basketball because of the injury. In addition, one year prior to admission his 25-year-old brother, who had in utero transmission of HIV, died of AIDS related complications. J. acknowledged he was sad, elaborating no further.Mother, who was HIV positive, reported that she had been increasingly ill beginning around the time of J.'s brother's death as a result of renal failure, which had required frequent dialysis, clinic visits, and hospitalizations. J. acknowledged worrying about her, especially when she was in the hospital. Her last discharge was two months prior to the beginning of his increasing withdrawal. During her hospitalizations J. stayed with an aunt, where he had to function with a higher level of independence than usual. He was required to take care of various daily needs himself, and take trains to come into the city. His aunt, who seems reliable, reported he was doing well, without decrease in functioning. As J. was not a reliable historian due to psychosis, and his mother provided sparse history, possibly due to her own illness and losses, this was helpful in establishing the beginning of the current syndrome.In this context, mother reported that J. had been acting normally until about four months prior to admission, when one day, without explanation, he stopped attending school. Within a month he was no longer leaving the apartment, and over the last several weeks he was refusing to leave his room. During this period J. was reported to be withdrawn and less communicative, as he rarely responded to direct questions. He ate and drank when his mother brought him food, but not much.Upon questioning, J. acknowledged hearing voices but would not disclose any details. He denied visual hallucinations, olfactory hallucinations, ideas of reference, and mood and anxiety symptoms. He admitted to smoking marijuana in the past but was unable to provide details. He denied suicidal or homicidal ideat...

show abstract

Modification of mitogen-driven lymphoproliferation by ceftriaxone in normal and immunocompromised mice

Cited by 9 publications

References 24 publications

A strain of Lactobacillus plantarum affects segmented filamentous bacteria in the intestine of immunosuppressed mice

A strain of Lactobacillus plantarum affects segmented filamentous bacteria in the intestine of immunosuppressed mice

Colonization and distribution of segmented filamentous bacteria (SFB) in chicken gastrointestinal tract and their relationship with host immunity

Ceftriaxone and Infection in First Episode Adolescent Psychosis

Contact Info

Product

Resources

About