Background. The use of microvascular free flaps is currently the favored method for the reconstruction of defects after resection of head and neck cancer. The flap most commonly used for head and neck reconstruction is the free radial forearm flap, but the less popular infrahyoid flap represents a good alternative in selected cases. This flap has proven to be helpful in the reconstruction of a wide range of moderate-sized head and neck defects.Methods. We reviewed a series of 13 patients with defects resulting from cancer of the head and neck, who underwent infrahyoid flap reconstruction as an alternative to free radial forearm flap. The series includes 12 squamous cell carcinomas arising from the oral cavity and oropharynx, and 1 Merkel cell carcinoma of the submental skin. In the harvesting of the flap, the technical modifications recently suggested by Dolivet et al were used in all cases. Furthermore, another technical change has been introduced so creating a new infrahyoid facio-myocutaneous flap (IHFMCF).The surgical technique is described in detail.Results. No total or partial flap necrosis was experienced. All reconstructions healed quickly without wound complications and with good functional results. The healing process in the donor site was excellent in every case with good aesthetic results.Conclusions. The IHFMCF is a versatile, reliable, and convenient flap suitable for repairing small and medium-sized defects of the oral cavity and oropharynx and obviates the need for a microvascular reconstruction. The main goals of modern head and neck reconstructive surgery are adequate wound healing, restoration of function, and appearance. In the preoperative planning, it is crucial to determine which reconstructive procedure will be most suitable for the patient to optimize functional outcome after cancer ablation. As a general rule, an optimal reconstruction should enhance the residual function allowing good motility of the preserved structures around the resected area, guarantee a quick and safe healing process, and provide a restoration of form with acceptable aesthetic results. The application of microvascular free flaps is the most widespread method currently employed for the reconstruction of extensive defects after resection of head and neck cancer because of their versatility and reliability. TheCorrespondence to: A. Deganello