Modification of the N-Terminus of a Calcium Carbonate Precipitating Peptide Affects Calcium Carbonate Mineralization

Abstract

These peptides mainly act as a catalyst rather than as a binder or component of the calcium carbonate deposits (as a template). On the other hand, the morphologies of the calcium carbonate deposits appeared to be dependent on the ability of the peptide to assemble and act as a template. Consequently, elucidating the relationship between peptide sequence and the ability of the peptide to assemble would be indispensable for controlling precipitate morphologies in the near future. This knowledge would provide important clues for elucidating the relationship between peptide sequence and mineralization ability, including deposit morphology and precipitating activity, for use in nanobiochemistry and materials chemistry research.

Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides

“…Therefore, the behavior of various molecules under MW irradiation requires detailed analysis to elucidate the effects of MWs on diseases and biological functions. In this study, we focused on calcium carbonate (CaCO 3 ) mineralization as a model biological reaction 15 – 23 , the process by which the exoskeletons of crustaceans, teeth, and bone are formed. Biomineralization is the precipitation of inorganics by biomolecules such as proteins and peptides 24 .…”

Effect of tryptophan residues on gold mineralization by a gold reducing peptide

“…For example, biomineralization (precipitation of inorganic compounds) systems can provide various inorganic precipitates following the addition of organic compounds such as proteins and peptides. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] The reaction conditions for the production of inorganic compounds in biomineralization systems are much milder than those used in conventional methods. Therefore, such inorganic compounds formed by mineralization have a low environmental load and reduced energy consumption.…”

“…(1) Small peptides derived from the sequences of proteins isolated for mineralization or articial sequences can precipitate many types of inorganic compounds. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] (2) Peptides can be conjugated with articial amino acids and functional molecules. 19,[26][27][28] (3) Peptides are easier to design and handle than proteins.…”

Elemental composition control of gold-titania nanocomposites by site-specific mineralization using artificial peptides and DNA

“…For example, in biomineralization systems, some proteins can be used to precipitate inorganic compounds. The function of such a system is to produce inorganic compounds on organic compounds such as proteins and peptides [9][10][11][12][13][14][15][16][17][18][19] . Inorganic compounds formed by mineralization are referred to as biominerals.…”

“…Peptides are promising compounds for use in nanocontrolled mineralization because they confer several advantages: (1) Small peptides derived from the sequence of isolated proteins for mineralization or artificial sequences can precipitate many types of inorganic compounds [9][10][11][12][13][14][15][16][17][18][19] . (2) Peptides can be conjugated with functional groups and molecules other than amino acids [20][21][22][23][24] , and such functionalized peptides can be distributed on wellshaped organic nanostructures that serve as templates for mineralization, such as DNA, which is used as DNA origami.…”