Modification of the responses evoked in the cerebellar cortex by limb nerve stimulation during wakefulness and sleep

Marchesi, G; Markel, E; Strata, Piergiorgio

doi:10.1016/0006-8993(70)90141-1

Cited by 4 publications

(1 citation statement)

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“…We found that the co-activation rate was significantly greater during wakefulness even though synchronous firing still occurred during sleep. Synchronized firing in the inferior olive during sleep is likely to occur at specific time intervals during which cortical drive is strongly elevated such as at the cusp of synchronized cortical oscillations, or during eye movement or twitch related bursts of activity that occur during desynchronized or REM sleep 86,87…”

Section: Attenuation Of the Rate Of Complex Spike Co-activation Durin...mentioning

confidence: 99%

Sleep-state dependent cerebellar processing in adult mice

Canto,

Bauer,

Hoogland

et al. 2023

Preprint

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The cerebellum is important for motor performance and adaptation as well as cognition. Sleep is essential for optimizing of all these functions, but it remains to be elucidated how sleep affects cerebellar processing. It has been suggested that sleep periods with muscle twitches entrain the cerebellum with a copy of motor commands and subsequent sensory feedback signals, to develop predictive coding of movements. If this hypothesis is correct, one expects phasic correlations between the muscle twitches and specific features of the electro-encephalography (EEG) recordings in the cerebellum during various sleep stages as well as the climbing fiber activity in the cerebellar cortex, the modulation of which is relayed from the cerebral cortex via mesodiencephalic junction and inferior olive.Here we provide evidence for coherent correlations between cerebellar and cerebral cortical sleep spindles, twitches as well as patterns of climbing fiber activity. Our data are compatible with the novel concept that muscle twitches evoke complex spike synchronicity during NREM, which in turn affects cerebellar spindle activity and cerebellar-cortical information flow, thereby entraining an internal forward model.

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Section: Attenuation Of the Rate Of Complex Spike Co-activation Durin...mentioning

confidence: 99%