Modified combination of platelet count and neutrophil “to” lymphocyte ratio as a prognostic factor in patients with advanced head and neck cancer

Nakayama, Masahiro; Gosho, Masahiko; Hirose, Yuki; Nishimura, Bungo; Tanaka, Shuho; Tabuchi, Keiji; Okubo, Hideki; Wada, Takahito; Hara, Akira

doi:10.1002/hed.25085

Cited by 18 publications

(28 citation statements)

References 37 publications

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“…4–6 Recently, the COP-NLR has been described as a prognostic indicator as well. 7, 8, 13 The COP-NLR system was originally developed to combine the inflammatory data from the NLR and information from reactive thrombocytosis in the platelet count. Building on the previous work by Nakayama, this study sought to find out if the COP-NLR was prognostic in a wide variety of HNCs in various stages.…”

Section: Discussionmentioning

confidence: 99%

“…21 Based on this knowledge, the COP-NLR was developed and validated in various cancers. 7, 13, 22–24…”

Section: Discussionmentioning

confidence: 99%

“…The pretreatment modified COP-NLR was also recorded, as described by Nakayama. 7 The NLR was defined as the neutrophil count divided by the lymphocyte count. The COP-NLR was graded as 0 for both NLR<3 and platelet count <3×10 9 /L.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, the combination of platelet count to neutrophil-lymphocyte ratio (COP-NLR) has been reported as a prognostic indicator in head and neck cancer 7 and other sites. 8 The study by Nakayama reported only in patients with advanced disease (Stage 3 and Stage 4 disease).…”

Section: Introductionmentioning

confidence: 99%

“…Another finding in their paper was that the modified COP-NLR was a better prognostic model than the other COP-NLR models, the 4-group COP-NLR model and the Original COP-NLR model. 7 In this context, we designed our study to report the effect of the modified COP-NLR in HNC patients of all stages.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Relationship between Markers of Systemic Inflammatory Response and Head and Neck Tumor Characteristics

Tham¹,

Khaymovich

Costantino

2018

Preprint

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BackgroundMarkers of systemic inflammation have been hypothesized to reflect the underlying tumor microenvironment, and have recently been shown to be associated with advanced tumor grade, T and N stages.Aims/ObjectiveThe objective of this study was to evaluate the relationship between head and neck cancer (HNC) tumor characteristics and routine pretreatment inflammatory markers: the platelet lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the lymphocyte to monocyte ratio (LMR).Materials and MethodsThis is a retrospective cohort study. The tumor characteristics collected were tumor differentiation, T stage, N stage. The relationship between the inflammatory markers and tumor characteristics was analyzed.ResultsA total of 122 patients were enrolled from 2010-2016. An elevated PLR was found to be significantly associated with advanced T stage (rho=0.191, p=0.00347), and N stage (ANOVA, p=0.005). None of the other inflammatory markers (NLR, LMR) were associated with T stage or N stage. No markers were associated with tumor differentiation.Conclusion and significanceWe found that an PLR is significantly associated with advanced tumor and nodal stage. We were unable to find any tumor associations with the other inflammatory markers (NLR, LMR).

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Section: Discussionmentioning

confidence: 99%

“…21 Based on this knowledge, the COP-NLR was developed and validated in various cancers. 7, 13, 22–24…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of the Relationship between Markers of Systemic Inflammatory Response and Head and Neck Tumor Characteristics

Tham¹,

Khaymovich

Costantino

2018

Preprint

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Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck

et al. 2020

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Background Neutrophil‐to‐lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States. Methods We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. We compared 5‐year overall survival and cancer‐specific survival for different NLR tertiles using cox proportional hazards modeling with adjustment for covariates. Results The primary cohort consisted of 14 644 subjects of which 99% were male. Relative to patients with NLRs in the lower tertile, patients with NLRs in the top tertile had an 71% increased hazard of all‐cause mortality (P < .001) and 44% increased hazard of cancer‐specific mortality (P < .001) at 5 years. Conclusions Elevated NLR in HNSCC confers a poor prognosis.

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DNA methylation‐derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

et al. 2022

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Background Head and neck squamous cell carcinomas are associated with systemic inflammation (SI). We evaluated whether DNA methylation‐derived SI (mdSI) indices are associated with oropharyngeal cancer risk and survival. Methods Ninety‐four oropharyngeal squamous cell carcinoma (OPSCC) cases and 57 controls with DNA methylation data were included. Logistic regression analysis and survival analysis were performed to test the association of mdSI indices with OPSCC risk and survival. Results Higher methylation‐derived neutrophil‐to‐lymphocyte ratio (mdNLR) was associated with increased risk of OPSCC (OR = 1.21, 95%CI: 1.11–1.40) while no association was found with methylation‐derived lymphocyte‐to‐monocyte ratio (mdLMR). For 5‐year overall survival, higher mdLMR was significantly associated with decreased risk of death (HR = 0.25, 95%CI: 0.10–0.64) while the converse was observed for mdNLR (HR = 2.48, 95%CI: 1.04–5.92). Conclusion We observed an association between mdSI indices and OPSCC risk and 5‐year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.

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Modified combination of platelet count and neutrophil “to” lymphocyte ratio as a prognostic factor in patients with advanced head and neck cancer

Abstract: The modified COP-NLR score is a useful prognostic marker in patients with advanced head and neck cancer.

Cited by 18 publications

References 37 publications

Investigation of the Relationship between Markers of Systemic Inflammatory Response and Head and Neck Tumor Characteristics

Investigation of the Relationship between Markers of Systemic Inflammatory Response and Head and Neck Tumor Characteristics

Neutrophil‐to‐lymphocyte ratio as a prognostic indicator for overall and cancer‐specific survival in squamous cell carcinoma of the head and neck

DNA methylation‐derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

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