Modified Cornell electrocardiographic criteria in the assessment of left ventricular hypertrophy geometry of patients with essential hypertension

Xu, Min; Ge, Zhixiang; Huang, Jun; Shao, Xiaoliang; Li, Jumei; Mrcp,; Yang, Junhua

doi:10.1111/jch.13919

Cited by 7 publications

(13 citation statements)

References 24 publications

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“…Few papers have addressed ECG criteria for Echo left ventricular geometry, and most studies are limited to patients with hypertension 6 , 7 , 10 . For example, a study that included 381 patients with hypertension correlated changes in the left ventricular geometry with the modified Cornell criteria RaVL + SD (the deepest S wave in 12-lead ECG), Sokolow-Lyon criteria (RV5/V6 + SV1), and Cornell criteria (RaVL + SV3) 7 . The study found that the distribution of the three criteria was different in all left ventricular morphologies (p ≤ 0.01 for all) 7 .…”

Section: Discussionmentioning

confidence: 99%

“…For example, a study that included 381 patients with hypertension correlated changes in the left ventricular geometry with the modified Cornell criteria RaVL + SD (the deepest S wave in 12-lead ECG), Sokolow-Lyon criteria (RV5/V6 + SV1), and Cornell criteria (RaVL + SV3) 7 . The study found that the distribution of the three criteria was different in all left ventricular morphologies (p ≤ 0.01 for all) 7 . However, only the modified Cornell criteria (ECG 31) were significantly different in all left ventricular geometries in univariate and multivariable analysis 7 .…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and specificity ranged from 44% to 68% and 64% to 84%, respectively 6 . Another study that included patients with essential hypertension found that the modified Cornell criteria (Ravl + SD, the deepest S wave in 12-lead ECG) have an increasing trend in the NL, CR, CH, and EH male groups in both unadjusted and adjusted models 7 . These studies show that the ECG can help predict Echo left ventricular geometry 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Another study that included patients with essential hypertension found that the modified Cornell criteria (Ravl + SD, the deepest S wave in 12-lead ECG) have an increasing trend in the NL, CR, CH, and EH male groups in both unadjusted and adjusted models 7 . These studies show that the ECG can help predict Echo left ventricular geometry 6 , 7 . However, many ECG criteria in the literature to predict left ventricular geometry remain unexplored.…”

Section: Introductionmentioning

confidence: 99%

“…However, in many clinical settings, the Echo is not available. In the absence of Echo, the electrocardiogram (ECG) could help predict Echo left ventricular geometry 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

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Utilidad diagnóstica del ECG para predecir la geometría del ventrículo izquierdo por ecocardiograma

De-la-Garza-Salazar¹

2022

ACM

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Objective: To explore the diagnostic utility of 31 electrocardiogram (ECG) criteria for detecting echocardiographic (Echo) left ventricular geometry using accuracy. Methods: This cross-sectional study included consecutive adults (> 18 years) that were classified by Echo left ventricular geometry as normal (NL), concentric remodeling (CR), concentric hypertrophy (CH), and eccentric hypertrophy (EH). Thirty-one state-of-the-art ECG criteria for Echo left ventricular hypertrophy were calculated. AUC 95%CI, accuracy, sensitivity, specificity, and positive and negative predictive value for detecting Echo left ventricular geometries were compared. Multivariable linear regression models were produced using the ECG criteria as the dependent variable. Results: A total of 672 adults were included in the study. From 31 ECG criteria, Cornell (ECG21, SV3 + RaVL) and modified Cornell (ECG 31, RaVL + deepest S in all leads) criteria have the best overall AUC in differentiating NL versus CH (0.666 and 0.646), NL versus EH (0.686 and 0.656), CR versus CH (0.687 and 0.661), and CR versus EH (0.718 and 0.676). In multivariable linear regression models, CH and EH had the strongest effect on the final voltage in Cor-nell (ECG21) and modified Cornell (ECG31). Conclusions: From 31 state-of-the-art criteria, Cornell and modified Cornell criteria have the best AUC and accuracy for predicting most left ventricular geometries. CH and EH had the strongest effect on the voltage of Cornell and modified Cornell criteria compared to body mass index, age, diabetes, hypertension, and chronic heart disease. The ECG criteria poorly differentiate NL from CR and CH from EH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, in many clinical settings, the Echo is not available. In the absence of Echo, the electrocardiogram (ECG) could help predict Echo left ventricular geometry 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Utilidad diagnóstica del ECG para predecir la geometría del ventrículo izquierdo por ecocardiograma

De-la-Garza-Salazar¹

2022

ACM

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Soluble ST2 Is a Biomarker Associated With Left Ventricular Hypertrophy and Concentric Hypertrophy in Patients With Essential Hypertension

Wang,

Han,

Wang

et al. 2024

American Journal of Hypertension

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BACKGROUND Elevated soluble stimulating factor 2 (sST2) level is observed in cardiovascular diseases, such as heart failure and acute coronary syndrome, which reflects myocardial fibrosis and hypertrophy, indicating adverse clinical outcomes. However, the association between sST2 and hypertensive heart disease are less understood. This study aimed to determine the relationship of sST2 with left ventricular hypertrophy (LVH) and geometric remodeling in essential hypertension (EH). METHODS We enrolled 483 patients (aged 18–80 years; 51.35% female). sST2 measurements and echocardiographic analyses were performed. RESULTS Stepwise multiple linear regression analysis showed significant associations between sST2, left ventricular (LV) mass, and LV mass index. The prevalence of LVH and concentric hypertrophy (CH) increased with higher sST2 grade levels (p for trend<0.05). Logistic regression analysis suggested that the highest tertile of sST2 was significantly associated with increased LVH risk, compared with the lowest tertile (multivariate-adjusted odds ratio [OR] of highest group: 6.61; p<0.001). Similar results were observed in the left ventricular geometric remodeling; the highest tertile of sST2 was significantly associated with increased CH risk (multivariate-adjusted OR of highest group: 5.80; p<0.001). The receiver operating characteristic analysis results revealed that sST2 had potential predictive value for LVH (area under the curve [AUC]: 0.752, 95% confidence interval [CI]: 0.704–0.800) and CH (AUC: 0.750, 95% CI: 0.699–0.802) in patients with EH. CONCLUSIONS High sST2 level is strongly related to LVH and CH in patients with EH and can be used as a biomarker for the diagnosis and risk assessment of hypertensive heart disease.

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Comparative efficacy of different types of antihypertensive drugs in reversing left ventricular hypertrophy as determined with echocardiography in hypertensive patients

Xu¹,

Hu²,

Wu³

et al. 2021

Medicine

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Background: Reversing left ventricular hypertrophy (LVH) can reduce the incidence of adverse cardiovascular events. The lack of direct comparison between different antihypertensive drugs cannot evaluate the superiority-inferiority differentiation of different antihypertensive drugs in reversing LVH. Therefore, the objective of this protocol for systematic review and meta-analysis was to compare the efficacy of different types of antihypertensive drugs in reversing LVH in hypertensive patients. Methods: This meta-analysis was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement guidelines. Studies were identified through systematic searches in June 2021 with no restrictions on date and time, language, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. The risk of bias assessment of the included studies was performed by two authors independently using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). All calculations were carried out with Stata 11.0 (The Cochrane Collaboration, Oxford, United Kingdom). Results: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. Conclusion: We hypothesized that the use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in antihypertensive therapy could achieve better efficacy in reversing LVH in hypertensive patients.

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Modified Cornell electrocardiographic criteria in the assessment of left ventricular hypertrophy geometry of patients with essential hypertension

Cited by 7 publications

References 24 publications

Utilidad diagnóstica del ECG para predecir la geometría del ventrículo izquierdo por ecocardiograma

Utilidad diagnóstica del ECG para predecir la geometría del ventrículo izquierdo por ecocardiograma

Soluble ST2 Is a Biomarker Associated With Left Ventricular Hypertrophy and Concentric Hypertrophy in Patients With Essential Hypertension

Comparative efficacy of different types of antihypertensive drugs in reversing left ventricular hypertrophy as determined with echocardiography in hypertensive patients

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