Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients

Dl, Jiang; Yang, Jingyu; Sy, Jiang; Fl, Yuan; Yl, Gu; Jp, Li; Zj, Pei

doi:10.4238/gmr.15028787

Cited by 10 publications

(10 citation statements)

References 30 publications

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“…To the best of our knowledge, this is the first randomized controlled clinical trial to evaluate low-frequency ultrasound and electric pulses for transdermal drug delivery with DCQD treatment for patients after a laparoscopic gastrointestinal surgery. This design reflects the daily practice of the combination of Chinese and Western medicine treatment options in many centers of China (9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of Chinese traditional medicine Dachengqi Decoction in the treatment of postoperative intestinal function recovery

Luo¹,

Feng²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Background: Intestinal dysfunction is not conducive to the recovery of patients after surgery. It is particularly important to restore the intestinal function as soon as possible. In recent years, ultrasonic drug penetration therapy as a new type of non-invasive therapy has been used to solve this problem, but its efficacy has not been confirmed.Methods: Single-centre, parallel, randomized controlled clinical trial in China that included 184 patients undergoing laparoscopic gastrointestinal surgery. Ninety-one participants were randomly assigned to lowfrequency ultrasound and electric pulses for transdermal drug delivery with Dachengqi Decoction (DCQD) (intervention group), and 90 were assigned to the control group after laparoscopic gastrointestinal surgery. The primary outcome was time to first flatus after surgery (by patient's subjective feeling). Secondary outcomes assessed the recovery time of bowel movement, time of the first defecation, postoperative gastrointestinal complications (e.g., nausea, vomit, and bloating), days of hospitalization and treatment costs. Results: Of 184 patients, 181 (98.4%) completed the trial. The sociodemographic characteristics and efficiency data were comparable in the two groups at baseline. The intervention group had a shorter mean time of bowel movement recovery than the control group [29.4 h (IQR, 22.0-35.0 h) vs. 33.7 h (IQR, 24.0-40.0 h; P=0.005)] and a shorter mean time to first flatus after surgery [35.8 h (IQR, 23.1-46.6 h) vs. 46.7 h (IQR, 25.9-61.3 h; P=0.012)]. Postoperative gastrointestinal reactions (e.g., nausea, vomit, and bloating) occurred in 28.6% in the intervention group and 43.3% in the control group (P=0.038). Two patients in the intervention group had electrical tingling sensations, and one patient had a skin rash during the treatment.There were no significant differences in the occurrence rates of AEs or SAE, days of hospitalization and treatment costs between the two groups.Conclusions: Low-frequency ultrasound and electric pulses for transdermal drug delivery with DCQD can shorten the time of bowel movement recovery and accelerate first anal exhaust after laparoscopic gastrointestinal surgery.

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Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of Chinese traditional medicine Dachengqi Decoction in the treatment of postoperative intestinal function recovery

Luo¹,

Feng²,

Wu³

et al. 2020

Transl Cancer Res TCR

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“…The main physiopathological mechanism underlying the constipation experienced by this patient was insufficient bowel motility. [ 13 ] According to previous studies, the possible functional mechanisms of moxibustion for improving constipation are as follows. The first one involves plasma substance P (SP), an excitatory gastrointestinal hormone that can contract the gastrointestinal longitudinal muscle and circular muscle, stimulate neuronal depolarization in the gastrointestinal wall, and accelerate gastrointestinal motility.…”

Section: Discussionmentioning

confidence: 99%

Treatment of poststroke constipation with moxibustion

Wen

Zhuang²,

Zhao³

et al. 2018

Medicine

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Rationale:Moxibustion, an important therapeutic measure of TCM, can stimulate acupoints to unblock the meridians and collaterals, regulate the function of qi and blood, support health, and expel pathogens. So it could be an effective and safe for the treatment of constipation and improvement of the quality of life in poststroke patients with constipation.Patient concerns:He has a history of constipation, with the defecation of hard, bound stool every 2 to 3 days with the help of glycerin enema.Diagnoses:Constipation for >6 months; Cerebral infarction for 9 months; Type 2 diabetes for 3 years. Hypertension for approximately 1 month.Interventions:From the fifth day after admission, 5 rounds of moxibustion with moxa cones were administered at the bilateral ST25 and CV6 acupoints.Outcomes:The patient successfully defecated within 1hour. Subsequently, the patient could maintain daily unobstructed defecation with a normal total stool weight and moderate hardness.Lessons:Moxibustion is effective and safe for the treatment of constipation and improvement of the quality of life in post-stroke patients with constipation.

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“…[49] In clinical, modified DCQD granules can improve the immune function in early SAP patients. [50] Moreover, DCQD decoction also can be combined with octreotide to treat patients with AP, [51] and based on the "six-hollow-organs," it also can treat hyperlipidemic acute pancreatitis (HLAP), which is better than conventional therapy. [52] DCQD protects SAP by down-regulating HMGB-TLR-4-IL-23-IL-17A-mediated neutrophil activation by targeting SIRT1.…”

Section: Dachengqi Decoctionmentioning

confidence: 99%

Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review

Cui

Zhou

et al. 2022

Journal of Pancreatology

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Acute pancreatitis (AP) is a disease characterized by local inflammation in the pancreas, followed by trypsin activation, and may result from multiple etiologies. Approximately 20% of AP can progress to severe acute pancreatitis (SAP), which can lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS). SAP mortality rates have remained high in recent years, but there are currently no specific drugs designed to reduce these rates. Clinical studies have shown that patients can reduce the symptoms of the disease and slow down the development of the disease after taking the Chinese medicine decoction. Basic studies have shown that in AP or SAP disease models, the use of Chinese medicine monomers can improve the condition of rates. These natural Chinese herbal products can improve pancreatitis, given their ability to act on multiple targets. However, they have not been widely employed clinically and studied sufficiently and thoroughly. Therefore, this review aimed to summarize the pathophysiological mechanisms underlying pancreatitis and review the potential role of natural Chinese herbs (monomers and decoctions) in clinical and basic research.

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Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients

Cited by 10 publications

References 30 publications

A randomized controlled trial of Chinese traditional medicine Dachengqi Decoction in the treatment of postoperative intestinal function recovery

A randomized controlled trial of Chinese traditional medicine Dachengqi Decoction in the treatment of postoperative intestinal function recovery

Treatment of poststroke constipation with moxibustion

Natural Chinese herbs for the prevention and treatment of acute pancreatitis: a narrative review

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