Modified dextrose prolotherapy for recurrent temporomandibular joint dislocation

The efficacy of dextrose prolotherapy over placebo for temporomandibular joint hypermobility: A systematic review and meta‐analysis

“…However, if the success criteria include reduction in mouth opening and pain scores as well, our meta‐analysis suggests that dextrose may have significant superiority over placebo. One may argue that in few of the uncontrolled studies of Ungor et al and Zhou et al, the authors have not found any significant reduction in mouth opening with dextrose prolotherapy. This may be due to small sample size of 10 patients in one of the studies and use of only single injection of dextrose in 63% patients by Zhou et al …”

“…MMO exhibited a tendency to decrease, but it was not statistically significant in their study. Zhou et al in a series of 45 patients, reported a success rate of 91% after dextrose prolotherapy. Success was defined as absence of any dislocation or subluxation episodes for 6 months.…”

Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection (Prolotherapy): A Randomized Controlled Trial With Long-term Partial Crossover

“…The direction and scale of these results are generally consistent with those of other reports of DPT for TMD and other musculoskeletal pain conditions. 11,20 One retrospective case series, 21 3 prospective case series, 14,22,23 and 2 RCTs 12,24 have reported favorable clinical outcomes of DPT for TMD, measured as a marked subjective reduction in episodes of painful subluxation. However, only 1 prospective case series and 1 RCT used a quantifiable pain measure (visual analog scale or NRS) as well as a measure of MIO (in millimeters), pre-and posttreatment.…”

Conservative Management of Second Metatarsophalangeal Joint Instability in a Professional Dancer: A Case Report

“…26,30,46,60 Additional treatments repeat this process, allowing a gradual build-up of tissue to restore the original strength of the area. Studies report that prolotherapy is helpful in treating tendinopathies and ligament sprains, 12,38,39,44,72 joint instabilities, 20,25,32,62,68,75,83 osteoarthritis, [57][58][59]61 and chronic musculoskeletal pain and low back pain when coupled with spinal manipulation or corticosteroid injections. 23,56 However, studies on the effectiveness of prolotherapy for foot and ankle injuries are limited, and blinded studies are lacking.…”