2023
DOI: 10.1038/s41541-023-00705-y
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Modified influenza M158–66 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge

Josien Lanfermeijer,
Koen van de Ven,
Harry van Dijken
et al.

Abstract: CD8 + T cells are promising targets for vaccination against influenza A virus (IAV) infection. Their induction via peptide vaccination is not trivial, because peptides are weakly immunogenic. One strategy to overcome this is by vaccination with chemically enhanced altered peptide ligands (CPLs), which have improved MHC-binding and immunogenicity. It remains unknown how peptide-modification affects the resulting immune response. We studied the effect of CPLs derived from the influenza M158–66 epitope (GILGFVFTL… Show more

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