Modified Neuroleptanesthesia Using Droperidol and Pentazocine

Abstract

Pentazocine was used as an alternative for fentanyl in combination with droperidol in neuroleptanesthesia and the results were compared with those of the ordinary techniques using droperidol and fentanyl or Thalamonal®. This modified technique proved to have advantages such as smooth induction of anesthesia, cardiovascular stability during surgery, rapid recovery of consciousness and postoperative tranquility, which were comparable to those of the ordinary techniques. Pentazocine caused less respiratory depression than fentanyl. Moreover, this technique was convenient for clinical practice, because the analgesic drug used was not narcotic. The longer duration of action of pentazocine appeared to be disadvantageous for the controllability of anesthesia, but it was considered to outweight the drawback in view of postoperative pain relief. The data of experimental studies also supported the clinical results. Pentazocine seemed to be a suitable alternative for fentanyl as a component of neuroleptanesthesia.-neuroleptanesthesia; droperidol; fentanyl; pentazocine

Effects of combined use of droperidol with pentazocine and with fentanyl on pulmonary hemodynamics.

“…pulmonary hemodynamics; droperidol; pentazocine; fentanyl Previously we reported that pentazocine produced pulmonary hypertension due to its direct vasoconstriction in anesthetized dogs, while fentanyl lowered pulmonary arterial pressure (Takahashi and Iwatsuki 1974). In clinical anesthesia, these analgesics are often used in combination with droperidol as neuroleptanesthesia (Iwatsuki et al 1971). Therefore, the present study was undertaken to investigate the pulmonary circulatory effects of droperidol combined with pentazocine and with fentanyl, and the results were compared with those of each analgesic alone in the previous report.…”

“…In clinical anesthesia, these analgesics are often used in combination with droperidol as neuroleptanesthesia (Iwatsuki et al 1971). Therefore, the present study was undertaken to investigate the pulmonary circulatory effects of droperidol combined with pentazocine and with fentanyl, and the results were compared with those of each analgesic alone in the previous report.…”

Effects of pentazocine on coronary hemodynamics under pentobarbital or chloralose-urethane anesthesia in dogs.

“…Recently it has been used also as an alternative for fentanyl in combination with droperidol in neuroleptanalgesia (Iwatsuki et al 1971). Regarding its circulatory effects pentazocine has been reported to produce an increase in heart rate and arterial blood pressure in conscious men (Feats and Telford 1964;Tammisto et al 1970; Mostert et al 1970) and in unanesthetized rabbits (Fogarty et al 1970).…”