Buildings are composed of several systems, each with specific designs and regulations to ensure that constructions are safe and viable. Many residential, commercial, and industrial buildings have systems with gas central storage, which must be subjected to strict safety criteria to avoid accidents. In addition to the safety mechanisms provided by manufacturers, designers of these gas central storage must consider other devices to reduce explosion risk and mitigate the damaging blast effects. Explosions are physical-chemical phenomena that are characterized by the sudden expansion of a material and, consequently, energy release. When an accidental explosion occurs, much damage is caused by the shock wave and fragments. In the case of pressure vessels, a mechanical explosion can occur. Studying this explosion is essential to developing a more reliable, safe design for surrounding buildings and its users. This work aims to study the effects of gas tank explosions. In this study, the Autodyn computational tool based on fluid dynamics (CFD) is used. This software allows the modeling of complex explosion scenarios and the evaluation of blast wave parameters. For each numerical model, the overpressure levels outdoors and indoors are evaluated. The results indicated how the wave overpressures are distributed in different scenarios, and from them, it was possible to analyze the damaging levels.