Modified release from hydroxypropyl methylcellulose compression-coated tablets

Rujivipat, Soravoot; Bodmeier, Roland

doi:10.1016/j.ijpharm.2010.09.021

Cited by 26 publications

(3 citation statements)

References 23 publications

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“…The hydrophilic polymers retarded the drug release more significantly than that of hydrophobic polymers. It was ascribed to the difference in mechanism of drug release (18)(19)(20). In detail, the former (hydrophilic polymers) released the water-soluble drug in a diffusion-controlled manner while the latter (hydrophobic polymers) released the drug via a mechanism of erosion and diffusion.…”

Section: Factors Affecting Mh Releasementioning

confidence: 99%

Bilayer Matrix Tablets for Prolonged Actions of Metformin Hydrochloride and Repaglinide

Huang

Zhou

et al. 2014

AAPS PharmSciTech

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A combination therapy of metformin hydrochloride (MH) and repaglinide (RG) achieves a perfect glycemic control; however, the combination formulation of immediate release must be taken several times a day, compromising the therapeutic benefits and causing inconveniences to the patients. Herein, a bilayer matrix tablet that aimed at continuously releasing both MH and RG over time was developed, in which the two drugs were formulated into two separated layers. The tablets were prepared by wet granulation method, and the optimized formulation was obtained by evaluating the factors that affected the drug release. The bilayer tablets simultaneously released the two drugs over 12 h; and a better in vivo performance with a steady plasma concentration, markedly lower Cmax, prolonged Tmax, and perfect absorption was obtained. Summarily, the bilayer matrix tablets sustained both MH and RG release over time, thereby prolonging the actions for diabetic therapy and producing better health outcomes.

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Section: Factors Affecting Mh Releasementioning

confidence: 99%

Bilayer Matrix Tablets for Prolonged Actions of Metformin Hydrochloride and Repaglinide

Huang

Zhou

et al. 2014

AAPS PharmSciTech

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“…These negatively charged nanoparticles improved the delivery of an incorporate macromolecule following oral administration [41]. A novel pulsatile release system for oral drug delivery has also been described that employs an enteric subcoating that eliminates drug diffusion through the gelled polymer coating layer prior to its erosion; the system incorporates varying ratios of a drug in the compression-coating layers in addition to the tablet core [42]. Thus, combinations of these new methodologies may offer novel approaches to facilitate the oral delivery of poorly soluble drug candidates that previously might have been rejected from oral screening.…”

Section: Improving Drug Solubility In the Upper Gi Tractmentioning

confidence: 99%

Oral drug delivery research in Europe

Mrsny

2012

Journal of Controlled Release

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The oral delivery of drugs is considered by decision-makers in the pharmaceutical industry to be the most appealing route of administration. This belief has led to the identification of many very successful drugs, but also to the downfall of some promising therapeutics that failed to meet criteria required for sufficient oral bioavailability. Efforts to correct these deficiencies have led to a plethora of creative strategies to overcome the physical, chemical, and biological barriers that limit the efficient and consistent delivery of drugs that are not readily absorbed following oral administration. The goal of this perspective is to describe these barriers to oral drug delivery in relation to some of the work currently being undertaken by the community of European scientists. This perspective is not intended to be inclusive and the author apologizes in advance to the many scientists working in Europe whose recent work was not included.

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“…A well-known water insoluble polymer, ethyl cellulose (EC) serves to modulate drug release as a controlling membrane. Hydroxypropyl methylcellulose (HPMC) is a widely used swellable polymer in the pharmaceutical industry that acts as an extended release agent [16,17] .…”

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confidence: 99%