2020
DOI: 10.1101/2020.04.23.047100
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Modular output circuits of the fastigial nucleus mediate diverse motor and nonmotor functions of the cerebellar vermis

Abstract: 1 2 The cerebellar vermis, long associated with axial motor control, has been implicated in a 3 surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably 4 little is known, however, about the specific cell types and neural circuits responsible for these 5 diverse functions. Here, using single-cell gene expression profiling and anatomical circuit 6analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, we identify 7 five major classes of glut… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
9
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(11 citation statements)
references
References 212 publications
2
9
0
Order By: Relevance
“…While some of these cell types can be tentatively matched to previously described morphologically-or electrophysiologically-defined cell types ( Fig. S12; see also (Fujita, Kodama, and Lac 2020)), the diversity uncovered from our study far exceeds previous reports.…”
Section: Mouse Cn Comprise Nucleus-specific Excitatory Neurons and Nusupporting
confidence: 49%
“…While some of these cell types can be tentatively matched to previously described morphologically-or electrophysiologically-defined cell types ( Fig. S12; see also (Fujita, Kodama, and Lac 2020)), the diversity uncovered from our study far exceeds previous reports.…”
Section: Mouse Cn Comprise Nucleus-specific Excitatory Neurons and Nusupporting
confidence: 49%
“…It is unclear whether GC hyperexcitability would increase or diminish net PC output because GCs directly excite and disynaptically inhibit PCs. We did, however, find that restraint stress increased c-Fos levels in the fastigial nucleus (FN) to a larger extent in cb d KO animals than in control animals (Figures 7B and 7C) and that FN neurons project to brain regions involved in motor and non-motor control (Fujita et al, 2020). These observations suggest that cerebellum-specific deletion of dGABA A Rs can result in hyperactivation of GCs and cerebellar nuclei.…”
Section: Differential Activation Of Many Brain Areas In Cb D Ko Animalsmentioning
confidence: 77%
“…The nucleus incertus has both indirect (via the septum) (Goto et al, 2001;Olucha-Bordonau et al, 2003) and direct (Szo †nyi et al, 2019) projections to the hippocampus, specifically targeting CA1 neurons in the stratum oriens (in line with our cFos results). Similarly, the septum and supramammilary nucleus may receive direct cerebellar projections (Heath et al, 1978;Fujita et al, 2020) and in turn project to the hippocampus (Soussi et al, 2010;Unal et al, 2015;Hashimotodani et al, 2018;Watson et al, 2019). Timed transynaptic tracing studies suggest a disynaptic pathway between the hippocampal formation and cerebellar nuclei, fitting with these pathways (Watson et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Purkinje cells typically project to the cerebellar nuclei. Cerebellar nuclei project to a number of thalamic nuclei (Haroian et al, 1981;Fujita et al, 2020), and it can be tempting to speculate on potential pathways to the hippocampus from these targets. Thalamic nuclei may have indirect effects on CA1 via retrosplenial (Werf et al, 2002), anterior cingulate (Rajasethupathy et al, 2015), or subicular (Y.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation