Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells

Zakaria, Sherin; Elsebaey, Samar; Allam, Shady; El‐Sisi, Alaa E.

doi:10.1016/j.biopha.2022.113562

Cited by 8 publications

(9 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SIAH family proteins are analogs of Drosophila SINA proteins, which have E3 ubiquitin ligase activity and can mediate the degradation of various proteins through the ubiquitination pathway 29,30 . SIAH is divided into two subtypes, SIAH1 and SIAH2, 31 among which SIAH2 has the effect of promoting tumor cell growth, and can promote the development of ovarian cancer, breast cancer, gastric cancer, and other malignant tumors through various pathways 13,32–34 . In breast cancer, SIAH2 primarily shows tumorigenic functions.…”

Section: Discussionmentioning

confidence: 99%

“…29,30 SIAH is divided into two subtypes, SIAH1 and SIAH2, 31 among which SIAH2 has the effect of promoting tumor cell growth, and can promote the development of ovarian cancer, breast cancer, gastric cancer, and other malignant tumors through various pathways. 13,[32][33][34] In breast cancer, SIAH2 primarily shows tumorigenic functions. Studies have found that SIAH2 silencing reduced breast tumor growth in vivo.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2

Wu,

Wang,

Zhang

et al. 2023

Molecular Carcinogenesis

View full text Add to dashboard Cite

Triple‐negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer, and chemoresistance is the major determinant of TNBC treatment failure. This study explores the molecular mechanism of TNBC chemoresistance. The Cancer Genome Atlas, breast cancer integrative platform, and GEPIA databases were used to analyze the expression and correlation of YTHDF1 and seven in absentia homology 2 (SIAH2) in breast cancer. Knockdown of YTHDF1 and SIAH2, or overexpression of SIAH2 in vitro and in vivo, was conducted to evaluate the impact of changes in YTHDF1 and SIAH2 expression on TNBC cell proliferation, apoptosis, stemness, drug resistance, and Hippo pathway gene expression. YTHDF1 and SIAH2 were highly expressed in breast cancer patients and TNBC cells. Knockdown of YTHDF1 and SIAH2 significantly inhibited proliferation and stemness and promoted apoptosis and chemosensitivity of TNBC cells. Mechanistically, the knockdown of YTHDF1 inhibited the expression of SIAH2, thereby downregulating the Hippo pathway, which inhibited proliferation and stemness and promoted apoptosis and chemosensitivity of TNBC cells. The current findings revealed the regulatory mechanism of YTHDF1 in TNBC and clarified the role of the YTHDF1/SIAH2 axis in TNBC drug resistance and stemness. This could provide new insights into the vital role of targeting YTHDF1/SIAH2 to suppress drug resistance and stemness in TNBC cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2

Wu,

Wang,

Zhang

et al. 2023

Molecular Carcinogenesis

View full text Add to dashboard Cite

show abstract

“…This phenomenon induces the release of factors such as hypoxia-inducible factor 1α (HIF-1α) that promotes not only EMT but also autophagy associated with CSC. In CRC it was demonstrated that blocking this factor with the consequent inhibition of autophagy reduces cell proliferation and the acquisition of stem-like characteristics[ 40 ].…”

Section: Colon Cancer Stem Cells: Features and Behaviormentioning

confidence: 99%

“…Besides the aberrant activation of several signaling pathways, hypoxia is known as a hallmark of CCSC and TME interaction[ 5 ]. This is a condition in the tumor niche whose main cause is the poor vasculature associated with the tumor and the upregulation of HIF-1α, a factor released mainly by ECs[ 40 , 71 , 72 ]. This condition activates Wnt/β-catenin pathway inducing self-renewal and maintenance of CCSC[ 50 , 73 ].…”

Section: Influence Of the Tme On Ccsc Featuresmentioning

confidence: 99%

See 1 more Smart Citation

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

Díaz¹,

Carriere²,

Gentili³

2023

World J Stem Cells

View full text Add to dashboard Cite

Colorectal cancer (CRC) remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant characteristics. It is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment failure. Nevertheless, in the last decades, CRC aggressiveness and progression have been attributed to a specific cell population called CRC stem cells (CCSC) with features like tumor initiation capacity, self-renewal capacity, and acquired multidrug resistance. Emerging data highlight the concept of this cell subtype as a plastic entity that has a dynamic status and can be originated from different types of cells through genetic and epigenetic changes. These alterations are modulated by complex and dynamic crosstalk with environmental factors by paracrine signaling. It is known that in the tumor niche, different cell types, structures, and biomolecules coexist and interact with cancer cells favoring cancer growth and development. Together, these components constitute the tumor microenvironment (TME). Most recently, researchers have also deepened the influence of the complex variety of microorganisms that inhabit the intestinal mucosa, collectively known as gut microbiota, on CRC. Both TME and microorganisms participate in inflammatory processes that can drive the initiation and evolution of CRC. Since in the last decade, crucial advances have been made concerning to the synergistic interaction among the TME and gut microorganisms that condition the identity of CCSC, the data exposed in this review could provide valuable insights into the biology of CRC and the development of new targeted therapies.

show abstract

Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Du,

Li,

Zheng

et al. 2023

Bioorganic Chemistry

View full text Add to dashboard Cite

Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells

Cited by 8 publications

References 63 publications

YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2

YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2

How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

Contact Info

Product

Resources

About