Modulation in the expression of type 1 (CR1/CD35) and type 3 (CR3/CD11b) complement receptors on leukocytes from patients with Visceral leishmaniasis

Campelo, C; Pinheiro, Igor Carvalho; Tavares, Bruno de Melo; Henn, Guilherme Alves de Lima; Fernandes, Camila; Albuquerque-Pinto, Luiz C.; Câmara, Lilia Maria Carneiro

doi:10.1016/j.exppara.2020.107970

“…This is more likely to occur in prolonged CIC formation or conditions with impaired clearance capacity 35 . In VL, several factors, including elevated levels of Igs, erythrocyte depletion, modulation of complement receptor 1 expression 38 , and impairment in phagocyte functions may contribute to the deposition of CIC.…”

Section: Introductionmentioning

confidence: 99%

A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis

Corrêa-Castro,

Silva-Freitas,

de Paula

et al. 2024

Sci Rep

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Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum. Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation with hypergammaglobulinemia. Although renal involvement has been recognized, a dearth of understanding about the underlying mechanisms driving acute kidney injury (AKI) in VL remains. We aimed to evaluate the involvement of immunoglobulins (Igs) and immune complexes (CIC) in the occurrence of AKI in VL patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment (mpt). Anti-Leishmania Igs, CIC, cystatin C, C3a and C5a were assessed and correlated with AKI markers. Interestingly, high levels of CIC were observed in VL patients up to 6 mpt. Concomitantly, twelve patients met the criteria for AKI, while high levels of cystatin C were observed up to 6 mpt. Plasmatic cystatin C was positively correlated with CIC and Igs. Moreover, C5a was correlated with cystatin C, CIC and Igs. We did not identify any correlation between amphotericin B use and kidney function markers in VL patients, although this association needs to be further explored in subsequent studies. Our data reinforce the presence of an important renal function impairment during VL, suggesting the involvement of Igs, CIC, and C5a in this clinical condition.

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“…This is more likely to occur in prolonged CIC formation or conditions with impaired clearance capacity 37 . In VL, several factors, including elevated levels of Igs, erythrocyte depletion, modulation of complement receptor 1 expression 40 , and impairment in phagocyte functions may contribute to the deposition of CIC.…”

Section: Introductionmentioning

confidence: 99%

A new look at acute kidney injury in human visceral leishmaniasis: the relationship with circulating immune complexes

Corrêa-Castro,

Silva-Freitas,

Paula

et al. 2023

Preprint

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Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum. Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation with hypergammaglobulinemia. Although renal involvement has been recognized, a dearth of understanding about the underlying mechanisms driving acute kidney injury (AKI) in VL remains. We aimed to evaluate the involvement of immunoglobulins (Igs) and immune complexes (CIC) in the occurrence of AKI in VL patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment (mpt). Anti-Leishmania Igs, CIC, cystatin C, C3a and C5a were assessed and correlated with AKI markers. Interestingly, high levels of CIC were observed in VL patients up to 6 mpt. Concomitantly, twelve patients met the criteria for AKI, while high levels of cystatin C were observed up to 6 mpt. Plasmatic cystatin C was positively correlated with CIC and Igs. Moreover, C5a was correlated with cystatin C, CIC and Igs. We did not identify any correlation between amphotericin B use and kidney function markers in VL patients, although this association needs to be further explored in subsequent studies. Our data reinforce the presence of an important renal function impairment during VL, suggesting the involvement of Igs, CIC, and C5a in the clinical condition.

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Importance the Type 1 (CR1) and Type 3 (CR3) Complement Receptors in the Infectious Disease

Campelo¹

2021

J Biomed Res Environ Sci

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Modulation in the expression of type 1 (CR1/CD35) and type 3 (CR3/CD11b) complement receptors on leukocytes from patients with Visceral leishmaniasis

Cited by 3 publications

References 16 publications

A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis

A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis

A new look at acute kidney injury in human visceral leishmaniasis: the relationship with circulating immune complexes

Importance the Type 1 (CR1) and Type 3 (CR3) Complement Receptors in the Infectious Disease

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