Modulation of Adiponectin and Leptin during Refeeding of Female Anorexia Nervosa Patients

Modan‐Moses, Dalit; Stein, Daniel; Pariente, Clara; Yaroslavsky, Amit; Ram, Anka; Faigin, Michal; Loewenthal, Ron; Yissachar, Eleanor; Hemi, Rina; Kanety, Hannah

doi:10.1210/jc.2006-1683

Cited by 87 publications

(65 citation statements)

References 26 publications

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“…Generally, assessment of total adiponectin showed a bi-phasic pattern with a temporary increase in the levels of this adipokine observed at the beginning of treatment and a gradual decrease thereafter [18,27,33]. However, in the current PRACE ORYGINALNE study we did not find significant differences between adiponectin levels when comparing AN individuals before and after refeeding.…”

Section: Prace Oryginalnecontrasting

confidence: 77%

“…In addition, there were no differences between the two groups of AN. The group of Modan-Moses was the first to report an increased proportion of HMW isoform in the malnourished phase of AN, followed by a decrease after weight gain to levels similar to control participants [33].Terra et al also observed a marked increase in HMW adiponectin in AN [18]. These authors found as well that HMW adiponectin related negatively with disease duration after adjustment for age.…”

Section: Prace Oryginalnementioning

confidence: 94%

“…However, other authors published contradictory data. The majority of researchers demonstrated that total adiponectin values were increased in AN individuals when compared with the controls [15,18,[30][31][32][33][34][35]. On the contrary, a decrease in adiponectin concentration in severely malnourished AN patients was reported by Tagami et al [36].…”

Section: Prace Oryginalnementioning

confidence: 99%

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Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

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Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissuederived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay. Results: Leptin and free leptin index (FLI) were lowest in treatment-naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group. Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content. (Endokrynol Pol 2017; 68 (4): 422-429)

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Section: Prace Oryginalnecontrasting

confidence: 77%

Section: Prace Oryginalnementioning

confidence: 94%

Section: Prace Oryginalnementioning

confidence: 99%

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Adipokine profile in patients with anorexia nervosa

Baranowska-Bik

Baranowska

Martyńska

et al. 2017

Endokrynologia Polska

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“…On the other hand, serum adiponectin inversely correlates with obesity, 2 while higher adiponectin levels have been documented in conditions of extreme malnourishment and severe energy deprivation. 17,18 Considering the aforementioned data, the results of our study could suggest that acute physical exercise per se does not regulate serum adiponectin levels, regardless of the intensity and the duration. Furthermore, the action of adiponectin as a starvation signal and a regulator of energy homeostasis is likely exerted in conditions of chronic energy restriction rather than acutely established energy deficit.…”

Section: The Effect Of Strenuous Prolonged Aerobic Exercise and Acutementioning

confidence: 68%

The effect of prolonged aerobic exercise on serum adipokine levels during an ultra-marathon endurance race

Roupas¹,

Mamali²,

Maragkos³

et al. 2013

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ObJEcTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners. DESIGN: The study included 17 highly trained ultra-endurance male athletes (mean age 51.29±6.84 years and body mass index (ΒΜΙ) 23.51±1.90) participating in the 5 th Olympian Race held in Greece on May 2010. Anthropometric values were assessed; serum cortisol, insulin, leptin, adiponectin, resistin and visfatin levels were measured at baseline, post-exercise and ~20 hours after the end of the race. RESULTS: All hormonal values of the post-exercise and recovery status were corrected for plasma volume changes. The estimated energy deficit during the ultra-endurance event was about 5000 Kcal. At the end of the race serum resistin levels were elevated (p<0.001) and serum leptin levels were reduced (p<0.001) and failed to reach pre-exercise levels, although showing a tendency towards restoration. No significant changes were noted in serum adiponectin and visfatin levels. cONcLUsIONs: Ultra-endurance aerobic exercise and acute negative energy balance lead to an up-regulation of serum resistin levels and a down-regulation of serum leptin levels.

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“…This lack of correlation with inflammatory mediators suggests that the levels of adiponectin multimers might be more linked to changes in glucose and lipid metabolisms at young ages. Figure 1 resumes the reported associations between total, HMW and LMW adiponectin with inflammatory mediators, hormones and other factors [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Adiponectin and Its Isoformsmentioning

confidence: 99%

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Nascimento¹,

Coimbra²,

Rêgo³

et al. 2017

Adiposity - Omics and Molecular Understanding

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Paediatric obesity has significant physic, social and psychological implications. Childhood obesity is usually associated in adulthood with increased risk of type 2 diabetes, metabolic syndrome and cardiovascular diseases. Aggregation of cardiometabolic risk factors is already observed at young ages, with a nonlinear association with enhancement of adiposity. Adiponectin is an adipokine that inhibits inflammation, oxidative stress and metabolic syndrome components, namely dyslipidaemia, high blood pressure and insulin resistance. Obesity has been associated with hypoadiponectinaemia in both adult and paediatric patients, which may contribute to co-morbidities observed in these patients. Interventional studies that aim to tackle obesity reported controversial results. Although the general positive effect on weight loss, inflammatory and cardiometabolic markers has been studied, the impact of these interventional studies on adiponectin remains unclear. Some studies reported that the improvement in adiponectin might only occur in paediatric obese patients with great weight loss or intensive physical exercise; the magnitude of the changes in body composition appears to be of particular importance. A revision about the knowledge on the relation between adiponectin, inflammation and cardiometabolic risk factors in paediatric patients is performed; the impact of interventional studies on adiponectin levels and markers of cardiometabolic risk is also addressed.

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Modulation of Adiponectin and Leptin during Refeeding of Female Anorexia Nervosa Patients

Cited by 87 publications

References 26 publications

Adipokine profile in patients with anorexia nervosa

Adipokine profile in patients with anorexia nervosa

The effect of prolonged aerobic exercise on serum adipokine levels during an ultra-marathon endurance race

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

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